Biotechnology
A method for regulating genes with electromagnetic response elements
Name of the inventor: Reba Goodman A non-invasive method for gene regulation
during gene therapy is described. The method involves the introduction of
electromagnetic field response elements into a gene promoter
more
Cumate-inducible expression system in eukaryotic cells, L-11648-11225
The cumate-inducible expression system allows turning on the expression of a
given protein only when needed
more
Erythropoietin
Method for high-yield enzymatic synthesis of non-ionic biosurfactants, L-10269
Enzymatic production of a broad range of biosurfactants including generation of
molecules that cannot be prepared using chemical synthesis
more
Method of differentiation of pluripotent stem cells to definitive endoderm
cells
Method for inducing differentiation of pluripotent stem cells to cells which are
precursors of tissues derived from endoderm. The cells obtained may be used for
regenerative medicine and somatic cell therapies
more
Non-invasive screening assay for early-stage colorectal cancer diagnosis
A non-invasive and robust hypermethylation assay for early diagnosis, prognosis
and monitoring of colorectal cancer. The preliminary results are very
encouraging indicating a sensitivity and specificity of more than 90%
more
Optimized large-scale transient gene expression with a serum-free
suspension-growing HEK293 cell line, L-11565
This technology presents key improvements in expression vectors, serum-free
media and process of a system for transient gene expression in human cells that
have significantly increased the ease and yield of r-protein production
more
Cardiovascular
A composition for treating or preventing a ryanodine receptor associated
disorder
Lead Inventor: Andrew R. Marks, M.D. Problem or Unmet Need: While progress has
been made in the treatment of various cardiovascular diseases, the increasing
incidence of heart failure (a syndrome resulting from long-term cardiac disease)
more
Inducible Serca2 KO mouse model for heart failure
Heart failure mouse model feasible as testing of potential new drug candidates,
test model for serious heart failure side effects and research in mechanisms of
heart failure including compensatory mechanisms
more
Central Nervous System
Method for early diagnosis of Alzheimer’s disease
The invention, reduced levels of specific amyloid β-protein degradation
products are significantly reduced in macrophages from AD patients compared to
controls, may form basis of a fast and predictive AD diagnostic assay
more
Novel once per day product opportunities for known compounds with additional
upside for decreased AE's
Technology enable QD product opportunity available for out-license
more
Dermatological
Antibiotic & steroid combination topical ointment
Novel patent pending in dermatology: combination of a well known topical
antibiotic with a topical steroid indicated for skin infections with
inflammatory process
more
HylaCare Product Line with Hylasome®
The Relief Line was designed to realize the advantages which have resulted from
the combination of Hylasome(R) technology with many of the modern active
materials used in the derma-cosmetic industry
more
Rx atopic dermatitis treatment avilable for pediatrics and PCP
Diagnostic
A method for using molecular networks in genetic linkage analysis of complex
disorders
Lead Inventor: Andrey Rzhetsky STV Reference: IR 1750 and IR 1902 Problem or
Unmet Need: One of the major practical goals of genetics is to find the genetic
origin of diseases and to understand how genetic mutations may alter particular
physiological
more
Kit for the diagnosis of diseases involving alteration of the inflammatory
response
Kit for the detection of diseases that occur with alteration of the systemic
inflammatory response or metabolic stress. Is based on new antibodies prepared
by our group, which are capable of specifically detecting and blocking
N-procalcitonin
more
Microarray-based gene translocation assay for differential diagnosis and
selection of treatment of cancers
A robust, computerized method for simultaneous detection and characterization of
fusion gene combinations. Prior knowledge about likely translocations not
required, can substitute PCR and FISH based testing in e.g. haematological
cancer diagnosis
more
Non-invasive screening assay for early-stage colorectal cancer diagnosis
A non-invasive and robust hypermethylation assay for early diagnosis, prognosis
and monitoring of colorectal cancer. The preliminary results are very
encouraging indicating a sensitivity and specificity of more than 90%
more
Drug delivery
Capsaicin patch
Capsaicin, the active ingredient found in red-hot peppers, is used mainly for
the relief of chronic pain of rheumatoid arthritis and osteoarthritis
more
TDS® - Liquid transDermal delivery system
A liquid system which enables rapid transmigration of therapeutic doses of up to
large molecules
more
Tulobuterol - TTS
The development of a transdermal therapeutic system offers the advantages of
constant plasma levels i.e. avoiding of plasma peaks and providing of
therapeutic plasma level during the early morning hours
more
Drug discovery
Fast and high yield recombinant proteins production by large-scale transfection
of suspension-growing mammalian cells, L-11266
High yield and low cost protein production in a few days to a couple of weeks
(mg or g of protein). Production of proteins, including antibodies, for
High-throughput screening assays, antibody generation and structure-activity
analyses
more
Identification of molecular formula of small molecules by mass spectrometry,
L-11740
This method provides an efficient tool for rapid and precise identification of
the molecular formula of small molecules, with some characterization of
sub-structures, without a cumbersome process of compound isolation
more
Method for high-yield enzymatic synthesis of non-ionic biosurfactants, L-10269
Enzymatic production of a broad range of biosurfactants including generation of
molecules that cannot be prepared using chemical synthesis
more
Retractable bivalent polypeptide inhibitors, L-11615
Retractable inhibitors controlled through polypeptide-protein interactions with
the flexible peptide bridge that link the two binding fragments may represent an
alternative approach to antidote-reversible anticoagulant therapy
more
Endocrinology
Out-licensing of modified-release gabapentin, a non-hormonal prescription
product for the treatment of menopausal hot flushes/flashes and related symptoms
associated with cancer therapies
Exclusive license for use of gabapentin in the above indications in EU, Canada,
Australia, New Zealand. US Phase 3 trials of MR-gabapentin for menopause by
PharmaNova’s US licensee (Depomed, Inc) will complete in 3Q 2009;
Co-promotion in US is possible
more
Recombinant FSH
Testosterone - TTS /LTS
Currently, LTS has two matrix formulation under development varying in their
manufacturing process
more
Gastrointestinal
Iron Sucrose
Iron Sucrose Injection, 20 mg/ml
more
Genito-urinary
A method of inducing formation of kidney epithelia from mesenchymal precursors
Name of the inventor: Jonathan M. Barasch A method of inducing the kidney
epithelium formation is described. Methods of treating a subject with kidney
failure, preserving a kidney for transplantation purposes are also proposed
more
Hospital and Surgery
Portable vital statistics monitoring and medication dispensing system (VMonitor)
Monitoring system to assist with daily medication routines
more
Immune related disorders
ImmLab's primary product: A Therapeutic Staphylococcal Lysate (SL) as
described in our patent 6,929,798 and 7,329,409 granted by the U.S. Patent and
Trademark Office
SL is prepared by lysis of S. aureus culture with a polyvalent bacteriophage
more
Infectious diseases
Method and kit for rapid detection and differentiation of Brucela SPP and
Mycobacterium Tuberculosis
Kit for rapid detection and differentiation of Brucella spp. and Mycobacterium
tuberculosis. The method allows the detection of both microorganisms through a
single reaction in only 45min
more
Medical device
Diaphragmatic and abdominalcompressions system
A new system to compress the abdominal and diaphragmatic areas of a patient, in
order to immobilize the area during irradiation. The compression system avoids
movements that can cause inaccuracies in the treated area during radiotherapy
more
Dummy for calibration and quality control ofvirtual simulation devices
New dummy for the calibration and quality control of virtual simulation devices
such as PET scanners, CT equipment, etc. Is designed to facilitate handling of
the radioisotopes needed to calibrate a PET device, rendering the the process
safer
more
Frame for securing thermoplastic mask
A new frame for securing thermoplastic masks for NMR and CT. The frame is
applied to immobilize the head of the patient and has two characterizing
features, that allow its insertion into a portable magnetic resonance device.
more
Gripping device for the extraction offixation elements
This iss a two jaws gripping device characterized by an impact piece fixed next
to the end of one of the gripping members of the device. It has been conceived
primarily for the purpose of facilitating the extraction of fixation elements in
Orthopedic Surgery
more
Surgical retraction device for the deep disection of pelvis
The device provides for separation and dissection of deep pelvis organs. It
offers an optimal view of the deep pelvis during rectal and mesorectal surgery.
It can also be used for separation and dissection of other structures such as
bladder, uterus, etc.
more
Metabolism
Bivalent Pyrazole derivatives as food intake modulators
A new family of bivalent pyrazole derivatives able to control food intake and to
induce satiety in mammals. These compounds constituted a promising alternative
to the exixting drugs for the treatement of diseases and conditions derived from
obesity
more
Composition for the treatment and prevention of diabetes mellitus
The new composition is a response to the problem of loss of function and/or mass
of beta-pancreatic cells due to diabetes mellitus. The composition comprises a
vascular endothelium growth factor and an inhibitor of its type 1 receptor
(VEGFR1)
more
Pyrazoles derivatives as specific activators of PPAR-Alpha receptors
These new compounds modulate the actions regulated by said receptors, namely
satiety induction and food intake control, reduction in body mass gain and the
regulation of fat metabolism
more
Oncology
Genetically modified human stem cells for clinical screening of oncogenesis
inhibitors
Modified human stem cells,so that they comprise the nucleotide sequence encoding
the fusion protein FUS-CHOP and partial or total depletion of the product of
expression of the gene coding for protein p53, useful tool for screening of
oncogenesis inhibitors
more
Granulocyte colony stimulating factor
Non-invasive screening assay for early-stage colorectal cancer diagnosis
A non-invasive and robust hypermethylation assay for early diagnosis, prognosis
and monitoring of colorectal cancer. The preliminary results are very
encouraging indicating a sensitivity and specificity of more than 90%
more
Pegylated Filgrastim
Oral Health
Dental bone grafts
Guided bone regeneration membrane in dental surgery
more
Research tools
A liposome-based microarray technology
Lead Inventor: Denong Wang Problem or Unmet Need: A protein microarray is a
coated glass slide onto which different proteins have been affixed in an ordered
fashion
more
A mouse model of cutaneous inflammation and hyperpigmentation
Lead Inventor: Dr. B. Jack Longley Problem or Unmet Need: The skin is
responsible for protecting the body from pathogens, temperature regulation, hair
growth and vitamin production
more
Antibody APA1/1 as a marker for TCR-engaged T cells
This antibody is specific for the TCR CD3 epsilon chain and can also be used to
identify this subunit in immunoprecipitation and immunoblotting applications
more
Simple and efficient method for the large-scale production of E1 deficient
adenovirus, L-10624
This technology provides a vector and a cell line that enables easy production
of replicant
more
A method of treating glaucoma
Name of the inventor: Cy Stein Topical administration of a modified
oligonucleotide for the treatment of glaucoma is discussed. The oligonucleotide
may be substituted or modified in its phosphate, sugar or base so as to decrease
the intraocular pressure
more
