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9th November 2009

Welcome to this week's news update...


Biotechnology

A method for regulating genes with electromagnetic response elements
Name of the inventor: Reba Goodman A non-invasive method for gene regulation during gene therapy is described. The method involves the introduction of electromagnetic field response elements into a gene promoter more
Cumate-inducible expression system in eukaryotic cells, L-11648-11225
The cumate-inducible expression system allows turning on the expression of a given protein only when needed more
Erythropoietin
rHu EPO more
Method for high-yield enzymatic synthesis of non-ionic biosurfactants, L-10269
Enzymatic production of a broad range of biosurfactants including generation of molecules that cannot be prepared using chemical synthesis more
Method of  differentiation of pluripotent stem cells to definitive endoderm cells 
Method for inducing differentiation of pluripotent stem cells to cells which are precursors of tissues derived from endoderm. The cells obtained may be used for regenerative medicine and somatic cell therapies more
Non-invasive screening assay for early-stage colorectal cancer diagnosis
A non-invasive and robust hypermethylation assay for early diagnosis, prognosis and monitoring of colorectal cancer. The preliminary results are very encouraging indicating a sensitivity and specificity of more than 90% more
Optimized large-scale transient gene expression with a serum-free suspension-growing HEK293 cell line, L-11565
This technology presents key improvements in expression vectors, serum-free media and process of a system for transient gene expression in human cells that have significantly increased the ease and yield of r-protein production more
 

Cardiovascular

A composition for treating or preventing a ryanodine receptor associated disorder
Lead Inventor: Andrew R. Marks, M.D. Problem or Unmet Need: While progress has been made in the treatment of various cardiovascular diseases, the increasing incidence of heart failure (a syndrome resulting from long-term cardiac disease) more
Inducible Serca2 KO mouse model for heart failure
Heart failure mouse model feasible as testing of potential new drug candidates, test model for serious heart failure side effects and research in mechanisms of heart failure including compensatory mechanisms more

Central Nervous System

Method for early diagnosis of Alzheimer’s disease
The invention, reduced levels of specific amyloid β-protein degradation products are significantly reduced in macrophages from AD patients compared to controls, may form basis of a fast and predictive AD diagnostic assay more
Novel once per day product opportunities for known compounds with additional upside for decreased AE's
Technology enable QD product opportunity available for out-license more

Dermatological

Antibiotic & steroid combination topical ointment
Novel patent pending in dermatology: combination of a well known topical antibiotic with a topical steroid indicated for skin infections with inflammatory process more
HylaCare Product Line with Hylasome®
The Relief Line was designed to realize the advantages which have resulted from the combination of Hylasome(R) technology with many of the modern active materials used in the derma-cosmetic industry more
Rx atopic dermatitis treatment avilable for pediatrics and PCP
Eletone cream more

Diagnostic

A method for using molecular networks in genetic linkage analysis of complex disorders
Lead Inventor: Andrey Rzhetsky STV Reference: IR 1750 and IR 1902 Problem or Unmet Need: One of the major practical goals of genetics is to find the genetic origin of diseases and to understand how genetic mutations may alter particular physiological more
Kit for the diagnosis of diseases involving alteration of the inflammatory response
Kit for the detection of diseases that occur with alteration of the systemic inflammatory response or metabolic stress. Is based on new antibodies prepared by our group, which are capable of specifically detecting and blocking N-procalcitonin more
Microarray-based gene translocation assay for differential diagnosis and selection of treatment of cancers
A robust, computerized method for simultaneous detection and characterization of fusion gene combinations. Prior knowledge about likely translocations not required, can substitute PCR and FISH based testing in e.g. haematological cancer diagnosis more
Non-invasive screening assay for early-stage colorectal cancer diagnosis
A non-invasive and robust hypermethylation assay for early diagnosis, prognosis and monitoring of colorectal cancer. The preliminary results are very encouraging indicating a sensitivity and specificity of more than 90% more

Drug delivery

Capsaicin patch
Capsaicin, the active ingredient found in red-hot peppers, is used mainly for the relief of chronic pain of rheumatoid arthritis and osteoarthritis more
TDS® - Liquid transDermal delivery system
A liquid system which enables rapid transmigration of therapeutic doses of up to large molecules more
Tulobuterol - TTS
The development of a transdermal therapeutic system offers the advantages of constant plasma levels i.e. avoiding of plasma peaks and providing of therapeutic plasma level during the early morning hours more

Drug discovery

Fast and high yield recombinant proteins production by large-scale transfection of suspension-growing mammalian cells, L-11266
High yield and low cost protein production in a few days to a couple of weeks (mg or g of protein). Production of proteins, including antibodies, for High-throughput screening assays, antibody generation and structure-activity analyses more
Identification of molecular formula of small molecules by mass spectrometry, L-11740
This method provides an efficient tool for rapid and precise identification of the molecular formula of small molecules, with some characterization of sub-structures, without a cumbersome process of compound isolation more
Method for high-yield enzymatic synthesis of non-ionic biosurfactants, L-10269
Enzymatic production of a broad range of biosurfactants including generation of molecules that cannot be prepared using chemical synthesis more
Retractable bivalent polypeptide inhibitors, L-11615
Retractable inhibitors controlled through polypeptide-protein interactions with the flexible peptide bridge that link the two binding fragments may represent an alternative approach to antidote-reversible anticoagulant therapy more

Endocrinology

Out-licensing of modified-release gabapentin, a non-hormonal prescription product for the treatment of menopausal hot flushes/flashes and related symptoms associated with cancer therapies
Exclusive license for use of gabapentin in the above indications in EU, Canada, Australia, New Zealand. US Phase 3 trials of MR-gabapentin for menopause by PharmaNova’s US licensee (Depomed, Inc) will complete in 3Q 2009; Co-promotion in US is possible more
Recombinant FSH
rHu FSH more
Testosterone - TTS /LTS
Currently, LTS has two matrix formulation under development varying in their manufacturing process more

Gastrointestinal

Iron Sucrose
Iron Sucrose Injection, 20 mg/ml more

Genito-urinary

A method of inducing formation of kidney epithelia from mesenchymal precursors
Name of the inventor: Jonathan M. Barasch A method of inducing the kidney epithelium formation is described. Methods of treating a subject with kidney failure, preserving a kidney for transplantation purposes are also proposed more

Hospital and Surgery

Portable vital statistics monitoring and medication dispensing system (VMonitor)
Monitoring system to assist with daily medication routines more
 

Immune related disorders

ImmLab's primary product: A Therapeutic Staphylococcal Lysate (SL) as described in our patent 6,929,798 and 7,329,409 granted by the U.S. Patent and Trademark Office
SL is prepared by lysis of S. aureus culture with a polyvalent bacteriophage more

Infectious diseases

Method and kit for rapid detection and differentiation of Brucela SPP and Mycobacterium Tuberculosis
Kit for rapid detection and differentiation of Brucella spp. and Mycobacterium tuberculosis. The method allows the detection of both microorganisms through a single reaction in only 45min more

Medical device

Diaphragmatic and abdominalcompressions system
A new system to compress the abdominal and diaphragmatic areas of a patient, in order to immobilize the area during irradiation. The compression system avoids movements that can cause inaccuracies in the treated area during radiotherapy more
Dummy for calibration and quality control ofvirtual simulation devices
New dummy for the calibration and quality control of virtual simulation devices such as PET scanners, CT equipment, etc. Is designed to facilitate handling of the radioisotopes needed to calibrate a PET device, rendering the the process safer more
Frame for securing thermoplastic mask
A new frame for securing thermoplastic masks for NMR and CT. The frame is applied to immobilize the head of the patient and has two characterizing features, that allow its insertion into a portable magnetic resonance device. more
Gripping device for the extraction offixation elements
This iss a two jaws gripping device characterized by an impact piece fixed next to the end of one of the gripping members of the device. It has been conceived primarily for the purpose of facilitating the extraction of fixation elements in Orthopedic Surgery more
Surgical retraction device for the deep disection of pelvis
The device provides for separation and dissection of deep pelvis organs. It offers an optimal view of the deep pelvis during rectal and mesorectal surgery. It can also be used for separation and dissection of other structures such as bladder, uterus, etc. more

Metabolism

Bivalent Pyrazole derivatives as food intake modulators 
A new family of bivalent pyrazole derivatives able to control food intake and to induce satiety in mammals. These compounds constituted a promising alternative to the exixting drugs for the treatement of diseases and conditions derived from obesity more
Composition for the treatment and prevention of diabetes mellitus
The new composition is a response to the problem of loss of function and/or mass of beta-pancreatic cells due to diabetes mellitus. The composition comprises a vascular endothelium growth factor and an inhibitor of its type 1 receptor (VEGFR1) more
Pyrazoles derivatives as specific activators of PPAR-Alpha receptors
These new compounds modulate the actions regulated by said receptors, namely satiety induction and food intake control, reduction in body mass gain and the regulation of fat metabolism more

Oncology

Genetically modified human stem cells for clinical screening of oncogenesis inhibitors
Modified human stem cells,so that they comprise the nucleotide sequence encoding the fusion protein FUS-CHOP and partial or total depletion of the product of expression of the gene coding for protein p53, useful tool for screening of oncogenesis inhibitors more
Granulocyte colony stimulating factor
rHu G-CSF more
Non-invasive screening assay for early-stage colorectal cancer diagnosis
A non-invasive and robust hypermethylation assay for early diagnosis, prognosis and monitoring of colorectal cancer. The preliminary results are very encouraging indicating a sensitivity and specificity of more than 90% more
Pegylated Filgrastim
Peg GCSF more
 
Oral Health 
Dental bone grafts
Guided bone regeneration membrane in dental surgery more

Research tools

A liposome-based microarray technology
Lead Inventor: Denong Wang Problem or Unmet Need: A protein microarray is a coated glass slide onto which different proteins have been affixed in an ordered fashion more
A mouse model of cutaneous inflammation and hyperpigmentation
Lead Inventor: Dr. B. Jack Longley Problem or Unmet Need: The skin is responsible for protecting the body from pathogens, temperature regulation, hair growth and vitamin production more
Antibody APA1/1 as a marker for TCR-engaged T cells
This antibody is specific for the TCR CD3 epsilon chain and can also be used to identify this subunit in immunoprecipitation and immunoblotting applications more
Simple and efficient method for the large-scale production of E1 deficient adenovirus, L-10624
This technology provides a vector and a cell line that enables easy production of replicant more

Sensory Organ

A method of treating glaucoma
Name of the inventor: Cy Stein Topical administration of a modified oligonucleotide for the treatment of glaucoma is discussed. The oligonucleotide may be substituted or modified in its phosphate, sugar or base so as to decrease the intraocular pressure more

Gastrointestinal

Unichem Laboratories Ltd. India seeks opportunities for in-licensing of NDDS and regular versions of pharmaceutical formulations
Unichem wishes to expand its current range of Gastro-intestinal formulations by partnering with companies and manufacturing / marketing their products under license, for the high potential Indian market more

Hospital and Surgery

Acquisition of UK Hospital established brands
UK partner for strategic divestments more

Pharmaceutical

DKSH seeks to in-license branded pharmaceuticals to market in Asia
We are looking for pharmaceuticals, OTC products or medical devices to in-license and commercialise in the Asian market more
Amarin is engaged in the development of innovative pharmaceutical products using its proprietary topical and transdermal drug delivery technologies and know-how.
Bioneer is a CRO research based company within recombinant protein production, immuno-regulatory assays, drug characterization and formulation and diagnostic biomarkers.
Oncology-focused development and commercialisation company.

Intas Biopharmaceuticals Limited (IBPL) and European pharmaceutical major Kwizda Pharma GmbH has jointly completed Phase I clinical trial study of NEUKINE®, biosimilar form of recombinant GCSF
Intas Biopharmaceuticals Limited (IBPL) and European pharmaceutical major Kwizda Pharma GmbH has jointly completed Phase I clinical trial study of NEUKINE®, biosimilar form of recombinant GCSF. more  

Galenix out-licenses drug delivery technologies to DSM Pharmaceutical Products and forms in a strategic alliance
Galenix today announced that it has out-licensed six drug delivery technologies to DSM Pharmaceutical Products, Parsippany, USA.  more

BioPartnering North America

24 -26 Jan 2010 — Vancouver, Canada

North America's Premier Life Science Partnering Conference BioPartnering North America (BPN) brings together decision-makers from leading biotechnology, pharmaceutical and investment companies from around the world for 3 days of focused networking, presentations, expert panels and one-to-one partnering.

Event details

Email event organizer

Genesis 2009

10 -11 Dec 2009 — Westminster, London, UK

The challenges of the economic downturn stimulated us to build innovative new partnerships at Genesis last year. The resultant exciting mix of business and science is something many have only dreamed of. This will be retained for 2009 with a streamlined approach for delegates to maximise the return on your investment in participating.

Event details

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