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ASTRAZENECA UPDATE ON CRESTOR

Release issued 6th August 2002

Following a constructive meeting with the US Food and Drug Administration (FDA) to discuss the company's response to the approvable letter for Crestor (rosuvastatin calcium), AstraZeneca has undertaken to provide further information from its ongoing study programme to supplement that already submitted.

This response to the approvable letter will support the use of Crestor over the dose range of 10-40mg in the general population of patients with lipid disorders and is scheduled for submission during the first quarter 2003.

There are now more than 10,000 patients in on-going studies of Crestor and the company remains confident in the product's profile and commercial potential.

The company's guidance on earnings for 2002 remains unchanged.

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