Name of the inventor: Paul Fisher A method for identifying a gene which is expressed at a modulated level in cancer and a method for identifying a compound which inhibits tumor growth are described. The method involves measuring a baseline mRNA...

Name of the inventor: Paul Fisher A method for identifying a gene which is expressed at a modulated level in cancer and a method for identifying a compound which inhibits tumor growth are described. The method involves measuring a baseline mRNA expression of a gene in a cancer cell and comparing this baseline value to the change in expression following the introduction of an expression vector. This assists in identifying a gene which is specifically expressed in a cancer cell. The method also identifies a compound which inhibits tumor growth in the cancer cell. A potential mechanistic framework by which polyethyleneglycol-3 (PEG-3) enhances the in-vivo cancer phenotype to tumor cells is revealed.

Pat. Title: PROGRESSIVE ELEVATED GENE-3 (PEG-3) INDUCES AGGRESSIVE CANCER PHENOTYPE AND REGULATES ANGIOGENESIS PROGRESSION ELEVATED GENE-3, INDUCES AN AGGRESSIVE CANCER PHENOTYPE IN RODENT AND HUMAN TUMOR CELLS AND REGULATES ANGIOGENESIS IN CANCER CELLS PROGRESSION ELEVATED GENE-3 (PEG-3) INDUCES AN AGGRESSIVE CANCER PHENOTYPE IN RODENT AND HUMAN TUMOR CELLS AND REGULATES ANGIOGENESIS IN CANCER CELLS PROGRESSION ELEVATED GENE-3, INDUCES AN AGGRESSIVE CANCER PHENOTYPE IN RODENT AND HUMAN TUMOR CELLS AND REGULATES ANGIOGENESIS IN CANCER CELLS PROGRESSIVE ELEVATED GENE-3 (PEG-3) INDUCES AGGRESSIVE CANCER PHENOTYPE AND REGULATES ANGIOGENESIS PROGRESSION ELEVATED GENE-3, INDUCES AN AGGRESSIVE CANCER PHENOTYPE IN RODENT AND HUMAN TUMOR CELLS AND REGULATES ANGIOGENESIS IN CANCER CELLS

Publication #: US20030044828A1 WO 01/46386 WO 01/46386

App. #: 10/177,811 PCT/US00/34564 60/173,114 60/173,114 PCT/US00/34564 10/177,811

Patent #: 6,982,148 6,982,148

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