Name of the inventor: Eric Kandel Title of the invention: Brain and heart cyclic nucleotide gated ion channel compounds and uses thereof An isolated nucleic acid encoding a BCNG protein, BCNG-related protein or their portions is described. Methods for...

Name of the inventor: Eric Kandel Title of the invention: Brain and heart cyclic nucleotide gated ion channel compounds and uses thereof An isolated nucleic acid encoding a BCNG protein, BCNG-related protein or their portions is described. Methods for identifying BCNG protein or a BCNG-related protein encoding nucleic acids in samples, detecting compounds capable of modulating BCNG protein or BCNG-related protein activity are also described. A pharmaceutical composition including a compound capable of modulating BCNG protein or BCNG-related protein activity and a pharmaceutically acceptable carrier, effective to treat a disease condition in a subject is also proposed. The method provides compounds capable of regulating the activity of ion channels which can be the site of integration of multiple electrical and biochemical pathways. ________________________________________________________________________________ Name of the inventor: Eric Kandel Title of the invention: Pacemaker ion channel proteins and uses thereof An isolated nucleic acid encoding a BCNG (brain cyclic nucleotide gated 1) protein or a BCNG-related protein or a portion of these proteins is described. A method for identifying a nucleic acid in a sample which encodes a BCNG protein or a BCNG-related protein is also described. A method for identifying a compound capable of interacting with/modulating a BCNG protein or a BCNG-related protein is also disclosed. A method of treating a condition in a subject by administering a pharmaceutical composition containing an effective amount of the compound is provided. The method can be used to treat conditions like epilepsy, Alzheimer's disease, Parkinson's disease, long QT syndrome, sick sinus syndrome, age-related memory loss, cystic fibrosis, sudden death syndrome or a pacemaker rhythm dysfunction.

Pat. Title: BRAIN CYCLIC NUCLEOTIDE GATED ION CHANNEL AND USES THEREOF BRAIN AND HEART CYCLIC NUCLEOTIDE GATED ION CHANNEL COMPOUNDS AND USES THEREOF BRAIN OR HEART CYCLIC NUCLEOTIDE GATED ION CHANNEL COMPOUNDS AND USES THEREOF BRAIN OR HEART CYCLIC NUCLEOTIDE GATED ION CHANNEL BRAIN OR HEART CYCLIC NUCLEOTIDE GATED ION CHANNEL BRAIN AND HEART CYCLIC NUCLEOTIDE GATED ION CHANNEL COMPOUNDS AND USES THEREOF BRAIN OR HEART CYCLIC NUCLEOTIDE GATED ION CHANNEL BRAIN OR HEART CYCLIC NUCLEOTIDE GATED ION CHANNEL BRAIN OR HEART CYCLIC NUCLEOTIDE GATED ION CHANNEL COMPOUNDS AND USES THEREOF BRAIN OR HEART CYCLIC NUCLEOTIDE GATED ION CHANNELCOMPOUND & USES THEREOF PACEMAKER ION CHANNEL PROTEINS AND USES THEREOF BRAIN OR HEART CYCLIC NUCLEOTIDE GATED ION CHANNEL

Publication #: 2003-0118988 A1 WO 99/32615 1042460 1032071A JP2002508930-W MX2000006306-A1 US 2004-0142421 A1 US 2005-0003477 A1

App. #: 08/997,685 09/086,436 PCT/US98/27630 20160/99 2315891 98964946.2 1102454.4 2000-525534 6306 10/753,991 10/384,107 05008950.7

Patent #: 6,551,821 6,703,485 B2 1042460

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