Name of the inventor: Cy Stein Topical administration of a modified oligonucleotide for the treatment of glaucoma is discussed. The oligonucleotide may be substituted or modified in its phosphate, sugar or base so as to decrease the intraocular pressure..

Name of the inventor:
Cy Stein Topical administration of a modified oligonucleotide for the treatment of glaucoma is discussed. The oligonucleotide may be substituted or modified in its phosphate, sugar or base so as to decrease the intraocular pressure and thereby treat glaucoma. The modified oligonucleotide is a homopolymeric/heteropolymeric phosphorothioate or phosphorodithioate. The phosphorothioate is stereo regular or stereo non-regular.
The oligonucleotide is conjugated to a carbohydrate or glycan. The method is useful in the treatment of glaucoma like acute glaucoma, absolute glaucoma, chronic glaucoma, congenital glaucoma, juvenile glaucoma, narrow angle glaucoma, open angle glaucoma, and simplex glaucoma.

Early Stage

Publication #: WO/1995/019776 WO1995/019776 (PCT) WO/1995/020043

App. #: 112382 08/640,404 08/184,223 112381 PCT/US95/00712 2181449 PCT/US95/00726 08/184,244

Licensing or sponsored research support

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