Name of the inventor: Steven P. Engebretson DDS, PhD Methods for facilitating metabolic control and for decreasing the level of circulating TNF in a subject are described. The use of anti-inflammatory agents in these methods is also discussed. The method.

Name of the inventor: Steven P. Engebretson DDS, PhD Methods for facilitating metabolic control and for decreasing the level of circulating TNF in a subject are described. The use of anti-inflammatory agents in these methods is also discussed. The method involves the use of an anti-inflammatory agent in facilitating metabolic control in a subject, comprising decreasing the level of IL- 1 ß in the Gingival Crevicular Fluid (GCF) by decreasing the level of circulating tumor necrosis factor (TNF) in the subject. The method is functional in countering chronic periodontitis and all types of diabetes in a subject. The method is especially useful in treating hyperglycemia.

Pat. Title: A Novel Method for the Treatment of Hyperglycemia USE OF KETOROLAC FOR TREATMENT OF PERIODONTAL DISEASE METHODS AND COMPOSITIONS FOR FACILITATING METABOLIC CONTROL Methods And Compositions For Facilitating Metabolic Control Methods and compositions for facilitating metabolic control METHODS AND COMPOSITIONS FOR FACILITATING METABOLIC CONTROL USE OF KETOROLAC FOR TREATMENT OF ORAL DISEASES AND CONDITIONS Use Of Ketorolac For Treatment Of Periodontal Disease Methods And Compositions For Facilitating Metabolic Control Use of Ketorolac For Treatment of Oral Disease And Conditions Use of Ketorolac For Treatment of Periodontal Disease Use Of Ketorolac For Treatment Of Periodontal Disease Use Of Ketorolac For Treatment Of Periodontal Disease USE OF KETOROLAC FOR TREATMENT OF PERIODONTAL DISEASE METHODS AND COMPOSITIONS FOR FACILITATING METABOLIC CONTROL Use Of Ketorolac For Treatment Of Periodontal Disease Methods And Compositions For Facilitating Metabolic Control Use Of Ketorolac For Treatment Of Periodontal Disease Use Of Ketorolac For Treatment Of Periodontal Disease Use Of Ketorolac For Treatment Of Periodontal Disease Use Of Ketorolac For Treatment Of Periodontal Disease Use Of Ketorolac For Treatment Of Periodontal Disease Methods and Compositions for Facilitating Metabolic Control Use of Ketorolac For Treatment of Periodontal Disease

Publication #: US-2005-0152850-A1 WO 91/13609 WO 2005/070058 US20050152850A1 US 2005-0256197 A1 WO 2005/070058 JP5505400-W US 2005-0256197 A1 MX184112-A WO 91/13609

App. #: 10/754,181 PCT/US91/01441 PCT/US05/00380 10/754,181 11/031,438 PCT/US05/000380 08/503,575 506128/91 11/031,438 08/280,163 08/511,493 24943 2077693 PCT/US91/01441 5705156.7 07/494,697 2,593,571 not known 1223455 not known not known EP 91906055.8 7100863.7 08/503,575

Patent #: WO 05/070058 5,785,951 3140050 5,464,609 5,646,174 184112 2077693 519983 519983 519983 5,785,951

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