Name of the inventor: Howard L. Kaufman An anti-cancer therapy for carcinoembryonic antigen (CEA) expressing solid tumors and a general method for developing bacterial vector towards tumors with known biomarkers. The inventors engineered a recombinant...

Name of the inventor: Howard L. Kaufman An anti-cancer therapy for carcinoembryonic antigen (CEA) expressing solid tumors and a general method for developing bacterial vector towards tumors with known biomarkers. The inventors engineered a recombinant strain of Salmonella typhimurium which expresses a small CEA receptor antibody. Bacteria specifically bind CEA expressing tumor cells through the recognition of the CEA epitope. There, they can deliver a payload of toxins, genes or cytokines to kill the cell. Salmonella proteins that bind intestinal epithelia or leukocytes were deleted from the genome, thus disrupting pathogenicity and reducing possibility of sepsis. The method enhances the safety of bacterial vectors and allows for the targeted delivery of noxious bacteria to specific cancerous cell types.

Early Stage

Pat. Title: A Composition for Delivering an Agent to a Target Cell and Uses Therof A Composition for Delivering an Agent to a Target Cell and Uses Thereof A Composition for Delivering an Agent to a Target Cell and Uses Therof A Composition for Delivering an Agent to a Target Cell and Uses Thereof A Composition for Delivering an Agent to a Target Cell and Uses Thereof A Composition for Delivering an Agent to a Target Cell and Uses Therof A Composition for Delivering an Agent to a Target Cell and Uses Therof COMPOSITION FOR DELIVERING AN AGENT TO A TARGET CELL AND USES THEREOF COMPOSITION FOR DELIVERING AN AGENT TO A TARGET CELL AND USES THEREOF

Publication #: WO 2004/076644 WO 2004/076644 US 2006-0083716 A1 US 2005-0008618 A1

App. #: 60/450,719 PCT/US2004/005866 10/789,627 US04/005866 11/213,499 10/789,627 60/450,719 10/789,627 60/450,719.

Licensing or sponsored research support.