, the composite materials of this technique can be applied to fill bone defect and replace, since they retain the excellent physical property.

□Materials for bone replacement with excellent physical property, □Little Toxicity anf High Biocompatibility ,□Osteo-conductive inorganic material modified on the surface by an polymerization inhib ,

l  Technology Platform

The core technology of YESBIO is to provide Composite Materials for Bone Replacement.  The Composite Materials according to this technique, maximize the merits of organic material and inorganic material and minimizes their demerits.  In detail, the organic material has the maintenance of shape and the adhesive property and the inorganic material has the osteo-conductivity on new bones.  Therefore, the composite materials of the present invention can be applied to fill bone defect and replace, since they retain the excellent physical property.

Background and unmet needs: Bone researches are investigated a lot in overall medical fields including dentistry and orthopedic surgery.  Materials for bone replacement should have excellent tissue compatibility, be available in unlimited quantities, be easy contoured, retain stable shape over time, become ingrowth or replaced by living tissue. However, there is no material suitable for this use yet.

In previous studies, the composite material combining inorganic material and organic material is being described.  Raveh et al. have investigated to manufacture the composite material by using bioglass and Bis-GMA(2,2-bis[4(2-hydroxy-3-methacryloxypropoxy) phenyl]propane).  However, this composite material is not absorbed completely and brings about adverse actions after operated.  Especially, it is recognized as a foreign body due to lacking in adhesiveness.

In addition, Wright et al. have contrived to prepare a composite material by mixing reinforcing fiber and PMMA.  This composite material may disperse the heat of polymerization from PMMAs to prevent bone necrosis during the reaction.  Nevertheless, this material has a too low adhesive strength as a glue to be applied actively.

Discovery and Achievements: Composite Materials for Bone Replacement of YESBIO has been developed on the basis of findings that novel methods for mixing β-TCP with CA without chemical modification.

First, β-TCP is encapsulated with other biodegradable polymers on the surface in order to facilitate their combination, even maintaining its physical property. 

Second, β-TCP is encapsulated on the surface with acids to be neutralized or acidified, since its surface is weakly basic.  This procedure makes these materials combined easily without additional components.

The organic material has the maintenance of shape and the adhesive property and the inorganic material has the osteo-conductivity on new bones.  Therefore, the composite materials of this technique can be applied to fill bone defect and replace, since they retain the excellent physical property. In Fig. 1, the composite materials represents significant physical property.

Early Stage

 

Country	Status	Patent, Publication or Appln. No.
Korea	Patented	10-2005-0048061
U.S.A.	Patented	11/296944

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