Skin color is determined by concentration and distribution of melanin in the skin. A multitue of approaches and researches have been made to improve skin conditions but have finally failed to effectively improve them.

Notably multiple effects, Singificant reduction of melanin amounts, Scavenging ROS,Inhibition of COX

l  Technology Platform

The core technology of BioSpectrum is to provide promising skin-whitening agents.  The α-bisabolol exhibits improvements of skin-whitening and anti-wrinkle, inhibition of UV-irradiated hair loss, stimulation of hair growth and anti-obesity.

Background and unmet needs: Skin color is determined by the accumulation and distribution of melanin which functions to block skin damages caused from the UV irradiation. The activities of tyrosinase is important to the synthesis of melanin. Therefore, the regulation of the activities of tyrosinase is a critical point for skin color.

A multitue of approaches and researches have been made to improve skin conditions but not effectively.

Discovery and Achievements:  The α-bisabolol of BioSpectrum has been developed on the basis of findings that camomile has multiple effects such as anti-inflammation, sedative activities and pain relief and α-bisabolol is a main active component of camomile essence oil.

The α-bisabolol derived from camomile is very effective in improving skin-whitening, anti-wrinkle and anti-obesity. In addition, the α-bisabolol exhibits effects on inhibition of UV-irradiated hair loss and stimulation of hair growth.

The B16 murine melanoma (B-16 F10) was seeded into 6-well plate (1×10⁵ per well) on DMEM and cultured at 37°C in 5% CO2 until above 80%. The α-bisabolol was treated to the samples at a concentration of 1 ppm, 5 ppm and 10 ppm and the samples were observed after 3 days of incubation. The amount of melanin per cells was measured at 490 nm using a microplate reader. The arbutin was served as a comparative agent.

Early Stage

Nation	Appln. No	Status	Description
PCT	PCT/KR08/01141	Published	COMPOSITIONS FOR IMPROVING SKIN CONDITIONS COMPRISING ALPHA-BISABOLOL AS AN ACTIVE INGRDIENT
KOREA	2007-0019899	Granted	COMPOSITIONS FOR IMPROVING SKIN CONDITIONS COMPRISING ALPHA-BISABOLOL AS AN ACTIVE INGRDIENT
JAPAN	2009-501364	Pending	COMPOSITIONS FOR IMPROVING SKIN CONDITIONS COMPRISING ALPHA-BISABOLOL AS AN ACTIVE INGRDIENT

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