Obese patients are unable to transport leptin from the blood into the brain because of the resistance at the blood brain barrier.

Summary

Obese patients are unable to transport leptin from the blood into the brain because of the resistance at the blood brain barrier. Normal leptin is transported via receptor-mediated trancytosis. It is believed that the receptor or transporter is impaired in obese patients and that this prevents the entry of the normal leptin to the brain. The invention chemically modifies leptin to transport leptin to the brain independently of its receptor or transporter.

Market Value

This is a novel method of delivering leptin across the blood brain barrier and allows obese patients to lose weight  and maintain and healthy weight.

Features & Benefits

• Easily cross blood brain barrier
• Administered by Intravenously or intranasally
• Long term weight loss maintenance
• Longer half life than the unmodified leptin

 

Early Stage

TID 168

UNeMed currently offers a variety of licensing options and collaborative development opportunities with the University of Nebraska Medical Center