
Visible port-wine stains are birthmarks, located mostly on the head and neck that affect about one million children in the U.S. alone, and cause significant psychosocial ramifications that worsen with age.
Currently clinicians use a trial-and-error approach to find the laser energy density and pulse time that will yield acceptable clinical responses to remove or reduce the stain. At present only 10% of the treated port-wine stains are completely cleared and 35% of treated port wine stains continue to progress, New England Journal of Medicine 2007; 356:1235 – 1240.
To significantly improve on the current low effective treatments, researchers have developed both a method and apparatus for personalized interactive laser therapy treatment of skin maladies in real time in which low radiant exposure from a laser hand piece. The process destroys the cutaneous capillaries which cause the stain without significant damage to the overlying skin. The current device slightly heats up the treatment site while an infrared sensor in the laser hand piece measures the temperature increases. A mathematical algorithm calculates the vessel size distribution at the treatment site and adjusts the radiant exposure of the device to specifically treat the site based on the vessel size distribution in the dermis.
This selective photothermolysis induces irreversible damage of the ecstatic capillary wall without damaging adjacent skin constituents. The process is non invasive, safe, and simple to operate. The final product is a significant advance for medical lasers used for dermal vascular therapy and hair removal.
Animal studies are ongoing and the clinical study is open for enrollment.
Patent Pending
Available for Exclusive Licensing
09-14 (T, D) Shafirstein
U.S. Provisional Patent Application filed 3/9/09 #61/209,578
Seeking a developmental partner to commercialize this novel medical therapy device
Mr. Charles Cook
Licensing Associate
UAMS BioVentures - TLO
Medical School - Teaching Hospital - Research Institution
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