Objective/function

• The laboratory is active in the study and treatment of traumatic brain injury (TBI)

Service provided

• Study of pathophysiology and basic mechanisms of neuroprotection and repair; development of potential novel therapeutic agents and strategies    
• Testing compounds developed by others for their potential neuroprotective effect in a well-established model of traumatic brain injury in mice

Advantages

• The animal model developed and widely studied in our lab for focal TBI serves as a platform for pre-clinical testing of potential drugs. We have a battery of neurobehavioral, motor and cognitive tests to assess the functional outcome after TBI and the effects of therapeutic intervention or genetic manipulations (e.g. transgenic o knockout mice)

Client service record

• Performed assessments of drugs for Pharmos, SK&B, Serono, Teva, and Bayer

Available equipment

• Device to produce closed head injury
• Set-up for evaluation of cognitive (object recognition test), behavioral (forced swimming test), and motor functions

Staff

• Alexander Alexandrovich, MD
• Victoria Trembovler, PhD