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Pharmalicensing
is a division of
UTEK Europe Ltd
UTEK Corporation
Out-licensing

Twinject® (epinephrine auto-injector ) licensing opportunity for territories outside of North America

Sciele Pharma Inc
Twinject – The only multi-dose epinephrine auto-injector for the treatment of anaphylaxis

Mechanism of action

Epinephrine is the most effective treatment available for anaphylaxis

Full description

Twinject competes in the epinephrine auto-injector market as a treatment for anaphylaxis.  It is the only auto-injector with two inseparable doses of epinephrine in a single device. Twinject is light weight, small in size, easy to carry and has the smallest gauge needle on the market.

Twinject directly addresses a number of the short comings of other auto-injectors.  Its innovative design provides the patient or caregiver an easy to use auto-injector with one of the easiest activation methodologies on the market.  Twinject also uniquely addresses the need for patients to have a second dose readily available, if it becomes necessary.

Twinject represents the first innovation in the epinephrine market in over 25 years.  It is a superior product compared to the current market leader in the U.S. Twinject does not require the competitor’s swing and jab technique in order to activate the injector.  Patient surveys in the U.S. showed 9 out of 10 patients who use the leading competitor product preferred Twinject ‘press and hold’ activation sequence.  When combined with a smaller gauge needle and the guaranteed availability of a second dose, Twinject should become the preferred product in most markets over time.

Twinject is indicated in the emergency treatment of severe allergic reactions (Type I) including anaphylaxis to stinging insects (e.g., order Hymenoptera, which includes bees, wasps, hornets, yellow jackets and fire ants), and biting insects (e.g., triatoma and mosquitoes), allergen immunotherapy, foods, drugs, diagnostic testing substances (e.g., radiocontrast media), and other allergens, as well as anaphylaxis to unknown substance (idiopathic anaphylaxis) or exercise-induced anaphylaxis.  Twinject is intended for immediate administration in patients with a history of anaphylactic reactions.

Twinject is available in dosage strengths of 0.15 mg or 0.3 mg (0.15 mL or 0.3 mL of 1:1000 dilution) of epinephrine. The first dose is available for auto-injection by the patient.  The second dose, if required, is available for manual injection by the patient following a partial disassembly of Twinject.

 

Development status

Preregistration

Patent information

Strong IP surrounds Twinject in the United States, Germany, Spain, France, Great Britain, Italy, Canada, Poland, Portugal, and Russia.

  • US Patent No. 7,297,136 expires January 18, 2025. It is an apparatus patent and a continuation of US Patent No. 5,665,071
  • EP Patent No. 0,700,307 expires May 26, 2014
  • Patent Cooperation Treaties were filed in 2007 and 2005.


 

Type of business relationship sought

Sciele is currently reaching out to selected potential partners for the commercialization of Twinject outside of North America.  The preferred transaction would involve out licensing of the product for appropriate upfront, milestone payments and royalties.  Sciele will provide finished product ready for labeling at a price to be determined.

Licensing contact

Mr Greg Michael
Director
Business Development

Contact directly

Company details

Sciele Pharma Inc

Sciele Pharma Inc. acquires, develops, and markets prescription medicines within cardiovascular, obstetrical and gynaecological, paediatric and gastroenterological disorders

View profile

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