New substituted phenyl compounds useful for the treatment of respiratory disorders e.g. extrinsic or intrinsic or atopic asthma, chronic bronchitis, bronchiectasis and emphysema - multifunctional ?-agonist compounds comprising a reactive oxygen...

New substituted phenyl compounds useful for the treatment of respiratory disorders e.g. extrinsic or intrinsic or atopic asthma, chronic bronchitis, bronchiectasis and emphysema - multifunctional ?-agonist compounds comprising a reactive oxygen species scavenger group and a nitric oxide donor, and their use for the treatment of respiratory diseases involving airway obstruction, such as asthma and chronic bronchitis. New substituted phenyl compounds useful for the treatment of respiratory disorders e.g. extrinsic or intrinsic or atopic asthma, chronic bronchitis, bronchiectasis and emphysema

Unique compound offers versatile administration for a wide variety of diseases

Categories	Asthma, diabetes mellitus, cardiovascular disease, respiratory distress syndrome, bronchitis, pneumonia, inflammatory bowel disease, neurodegenerative disease, endothelial dysfunction, angina, hypertension, congestive heart failure, erectile dysfunction, renal disorders
Development Stage	Concept proven
Patent Status	Patent WO 2004/037843 A2
Market Size	$60B

Highlights

• Medications act simultaneously as steroids, superoxide dismutase (SOD) mimic component, and nitric oxide (NO) donor, with synergistic effects, increasing their efficacy
• Administrable orally, topically, intravenously or through inhalation
• May be administered in lower dosages than traditional steroids and results in reduced side effects, hypersensitivity, tolerance and toxicity

Our Innovation

• agonist compounds capable of acting as both nitrogen oxide donors and as scavengers of reactive oxygen species, combined with improved steroid compounds that include superoxide dismutase mimic groups and nitric oxide donor groups
• Multifunctional steroid compounds include at least one superoxide dismutase (SOD) mimic component, a steroid component, and at least one nitric oxide (NO) donor component
• Provides prophylaxis and treatment of conditions involving oxidative stress and free-radical injury; respiratory, inflammatory, and autoimmune disorders; arthritis, allergic conditions, inflammatory bowel diseases, neurodegenerative diseases
• All compounds are small molecular weight molecules with sufficiently balanced water solubility and membrane permeability to be orally bioavailable

The Opportunity

• Addresses a wide range of disease entities
• Versatility of administration route expands marketability
• Reduces side effects and tolerance issues present in currently marketed medications

project-id 7-2006-315

Patent WO 2004/037843 A2