10 new reducing molecules, prolonging their redox and protective activity. RC3 and RC4, were shown to be: Potent ROS scavengers (50 to 100 fold compared with known antioxidants), Protect cells from glucose-induced oxidative-stress. Th+D126e molecular target in the cells was identified as the MAPK stress pathway demonstrated by inhibiting phosphorylation of two MAPK, JNK and p38. Redox Cluster, immunology, diabetes, Inflammation; Viral Infection; Retinopathy; Neuropathy, Aging; Cataract, Viral Infection, Athroseclerosis; Antioxidants; Neurodegenerative, Diseases

Protects cells from oxidative stress damage

Highlights

• Multicomponent antioxidant compounds used for reducing or preventing oxidative stress
• Destroys excessive accumulation of free radicals responsible for cell damage
• Application: treatment of diseases in which oxidative stress plays significant role, including diabetes, cataract, viral infection, atherosclerosis, brain damage after surgery, Alzheimers, Parkinsons, muscular dystrophy, stroke, allergy, asthma, AMD and others

Our Innovation

• A novel family of low molecular weight antioxidants called a redox cluster (RC).  The RC diffuses through the cell membrane due to structural and chemical properties.  Inside the cell, it fragments into more than ten new antioxidants.  The RC compounds lower oxidative stress, a common mechanism underlying chronic disease, by effectively scavenging free radicals and reactive oxidative substances.

Key Features

• Penetrates rapidly into cells and protects cell function from within the cell
• Very effective due to the two thiol groups and the large number of thiol containing fragments generated inside the cell
• Relevant to treatment of numerous diseases and medical disorders
• Development Milestones
• Extending studies of RC3 and RC4 and characterizing the biological properties of other newly-developed series of antioxidants in vitro and in animal models
• Proof of concept in lab and animal models

The Opportunity

• Successful use of antioxidants by millions worldwide, reflected by sales of vitamin E, vitamin C, and others
• Large increase in number of people who suffer from diabetes type-2, called the epidemic of the 21st century; also neurodegenerative diseases such as Parkinsons, Alzheimers, and multiple sclerosis

project-id 12-2006-149

UK patent 2368339; patent pending in U.S., EU, Canada, Japan, and Israel, PCT WO 02/34202