Currently only a few small molecule inhibitors are effective in patients with renal cell carcinoma. Approximately 30,000 patients per year are diagnosed with this disease but many of them are untreatable because of intrinsic drug resistance, and efficient drug transport and detoxification mechanisms. This invention described and claimed in the patent application describes a series of dimethane sulfonate compounds based on NSC 281612 that are suitable for the treatment of renal cancer. Compositions comprising a pharmaceutically-acceptable carrier and a compound, or a salt suitable for use in the treatment or prevention of renal cancer are also described. The anti-tumor activity of NSC 281612 has been established in vivo against human renal tumor xenografts in mice. Suitable dosing and administration schedules for treatment of renal tumors have also been determined in this study.
For treatment or prevention of renal cancer.
The technology is currently in the pre-clinical stage of development. Phase I clinical trials will begin this fall.
U.S. Patent Application No. 12/083,583 filed 14 Apr 2008, claiming priority to 14 Oct 2005 (HHS Reference No. E-249-2005/0-US-04)
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