The University of Liege has discovered a new tetrahydroisoquinoline and its derivatives and their preparation exhibiting a significant affinity for SK channels, particularly at the Apamin-sensitive sites of SK channels.

The Small conductance calcium activated potassium (SK) channels underlie the prolonged post-spike afterhyperpolarization (AHP), which plays an important role in modulating the firing rate and the firing pattern of neurones.

Up to now, Apamine extrated from the venom of honeybee is said the most potent SK channel bloker. However, it can’t be used for therapeuticals treatment due to its toxicity. Deliqualinium and its derivatives present a poor therapeutic action for the treatment of CNS diseases.

The University of Liege has discovered a new tetrahydroisoquinoline and its derivatives and their preparation exhibiting a significant affinity for SK channels, particularly at the Apamin-sensitive sites of SK channels.

Preclinical

WO 2007/107442  pending.

Opportunities are available,

research contract  and/ collaboration  for the test and development of the molecule