Summary
The present invention provides methods that allow for real time
detection of endothelial dysfunction, particularly arterial
endothelial dysfunction, in major blood vessels by imaging
microbubbles retained on vessel endothelium after microbubble
injection. Since ultrasound typically destroys microbubbles, a low
mechanical index pulse sequence scheme in a high frequency
linear array transducer is used to detect retained microbubbles.

Market Value
This invention will improve the outcome of individuals who are at
risk to vascular disease through accurate detection of endothelium
dysfunction, allowing for early therapeutic intervention.

Features and Benefits
• real-time detection of endothelial dysfunction
• non-invasive procedure
• direct visualization methods for more accurate diagnosis

Issued

TID 32

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