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Out-licensing

Novel target anti-lung cancer siRNA therapies, treatment drugs

Korea Health Industry Development Institute
Neomics has found a very promising target, AIMP2/AIMP2-DX2 for siRNA therapy application to tumoric lung cancer cells and we intend to focus the remaining resources on developing through clinical trials, the siRNA therapy as a first priority

Mechanism of action

AIMP2 (Aminoacyl-tRNA synthetase-interacting multifunctional protein 2) Previously known as p38/JTV-1_AIMP2-DX2Splicing variant of AIMP2 that inactivates normal activity of AIMP2

Full description

 

. Unique Merits of AIMP2 Targeting Anticancer Drugs

1.     Previously Unexplored Target with Novel Working Mechanisms

             (Global Initiatives in R&D and IP Position)

2.     Generation of Tumorigenic Variant of AIMP2 Is  Major Cause for Lung Caner

(Cancer-specific Target Available)

3.     Suppression of AIMP2-DX2 Proven Effective against Lung Cancer

4.     Small Chemical and siRNA Drug Candidates Are Available

5.     Patents for Material and Usage Are Established Worldwide

 

. Our Products to develop

•      Si-DX2 therapy -

–      Specific AIMP2-DX2 inhibitor

–      Aerosol inhalation administration

–      Low toxicity and high efficiency of delivery

•      Diagnostics

–      Immuno histochemical Method

–      QPCR AIMP2DX2 detection

–      RISH detection system

–      AIMP2 targeting small chemical drugs

–      4 drug candidates identified

Animal efficacy show

 

Development status

Early Stage

Patent information

 

 

AIMP2 Patent Portfolio:

Country

Patent or Patent Application Title

Patent or Patent Application Number

United States

Method for treating cancer using p38/JTV-1 and method for screening pharmaceutical composition for treating cancer

US 2004/0175375

10/463,676

18 Jun 03

 

Europe

Medical use of p38/JTV-1

EP 1454628

09 Sep 03

Japan

Pharmaceutical composition for cancer therapy with p38/JTV-1 as active ingredient and method for screening the composition

JP 2003-377932

07 Nov. 2003

 

Korea

Pharmaceutical composition for treatment of cancer containing p38/JTV-1 as effective component and screening method of pharmaceutical composition for treatment of cancer

KR 2003-18424

25th  Mar 2003

 

 

 

 

AIMP2-DX2 Patent Portfolio:

Country

Patent Application Title

Patent Application Number

Korea

Use of AIMP2-DX2 for the diagnosis and treatment of cancer

KR10-2005-0110946

18th March, 2005

Korea

Use of AIMP2-DX2 for the diagnosis and treatment of cancer

KR10-2006-0047831

26th May, 2006

International (PCT)

Use of AIMP2-DX2 for the diagnosis and treatment of cancer

PCT/KR2005/003924

18th March, 2005

United States

AIMP2-DX2 and its uses

US 11/264,725

 1st   Nov. 2005

Europe

AIMP2-DX2 and its uses

EP05819055.4

4th April, 2007

China

AIMP2-DX2 and its uses

CN200580037802.9

 30th April, 2007

Japan

AIMP2-DX2 and its uses

JP2007-542907

24th May, 2007

 

 

Type of business relationship sought

 

1. Overseas Licensing Opportunity

2. Seeking potential corporate partners

 

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