Out-licensing

Type IV Collagen is the most abundant protein found in the extra cellular matrix of Kidney and is turned over on a regular basis in the normal state. It is found in the renal proximal tubular cell basement membrane and is a mediator of renal development and function.  In addition, Type IV Collagen, selectively promotes the repair of physiological processes in sublethally injured renal proximal tubular cells.    These relationships may extend to the management of renal function in end stage renal disease

Studies demonstrate that L-ascorbic acid-2-phosphate and exogenous collagen IV acts to promote renal proximal tubular cell regeneration through the restoration of interactions between collagen IV and collagen-binding integrins (CBI).

Methods and pharmaceutical compositions are provided to recover cellular functions in injured cells, by contacting the injured cell with collagen IV, or a natural or mutated fragment thereof and a topically acceptable carrier, or administering therapeutically effective amounts of collagen IV.

02-28 (E) Schnellmann