T-go (SPHO220) is indicated for the management of teething, including the relief of its most common symptoms, such as painful and swollen gums.

The functional components of T-go (SPHO220) namely Glycyrrhetinic acid (GA) and Saffron create a synergistic effect to reduce the pain and inflammation during teething and to soothe the gums.

T-go (SPHO220), a novel formulation based on clinical evidence which includes key ingredients that work synergistically creating a particularly effective gel to alleviate symptoms associated with teething. Particular attention has been paid to avoid the use of chemical compounds (like anaesthetics) and some natural compounds (like honey or mint), that can be harmful. The functional components of T-go (SPHO220) create a synergistic effect to reduce the pain and inflammation during teething and to soothe the gums. Moreover, this product also helps to restore infants' oral environments that can be modified during teething.

Aloe vera was added to the teething gel in order to help care for babies' delicate mucosa. It is composed of a polysaccharide mixture that is able to form a protective film on the epithelial surface. Aloe vera has been shown to protect mucosa from trauma and inflammation, including microbial infections, through its capacity to form a film/gel upon topical application.

Hyaluronic acid (HA) has been shown to provide further protection. Studies have related the expression of HA to the development of mineralized dentine tissue. The presence of HA has been observed before and during eruption. Authors demonstrated that hyaluronate exists in the dental epithelium and in the dental papilla , which may contribute to the healing properties of saliva, assisting in protecting the oral mucosa and adding to the lubricating properties of saliva.

Glycyrrhetinic acid (GA) is one of the main active ingredients of liquorice extract. Its well demonstrated anti-inflammatory activity, with no known side effects, makes it a top-of-the-line anti-inflammatory agent. Its anti-inflammatory action is important during teething in order to reduce pain and to contrast the increase of inflammatory chemokines observed in the crevicular fluid. But the inflammatory activity is not the only interesting action of GA; some authors found that it has an antiplaque activity as well.

Saffron was included as a constituent of T-go (SPHO220) in a small amount (to avoid its bitter taste), as it has clinically proven antinociceptive and anti-inflammatory properties.

T-go (SPHO220) is a yellow gel that comes in a specially designed tube that has a soft rubber brush applicator at its end. The gel is squeezed out of the centre of the applicator onto the gums permitting an even application of the product while simultaneously massaging and soothing the painful gums.

Product advantages

T-go (SPHO220) has many benefits when compared to its competitors. The most significant difference is that T-go (SPHO220) does not contain local anaesthetics. Local anaesthetics have very well-known side effects that can be extremely worrying for parents, such as drowsiness, dizziness, twitching, restlessness and tremors. T-go (SPHO220) is anaesthetic-free and thus is a much safer option.

Many natural remedies for teething have been shown to be ineffective, outdated and even dangerous, containing potentially unsafe natural ingredients, such as honey, which can carry botulism spores. T-go (SPHO220) does not have any harmful natural substances, reinforcing once again that it is a safe formulation.

T-go (SPHO220) does not contain potentially irritating substances such as alcohol, unlike other teething treatments. In addition, T-go (SPHO220) is sugar-free.

Finally, T-go (SPHO220) contains key ingredients, such as Aloe vera, HA, GA and saffron, in proportions able to control the numerous and disturbing teething symptoms.

Disease overview

Teething is the process of primary teeth cutting through the gums and appearing in an infants mouth. Although the average time for the appearance of the first teeth is between five and seven months of age, there is a wide normal variation of timing. All of the primary teeth are usually in by 20 to 30 months. Researchers have identified drooling, appetite disturbance, sleep disturbances, restlessness, coughing, rash, and diarrhea as symptoms associated with teething.

A recent study revealed high levels of inflammatory cytokines during the teething period, evaluated in gingival crevicular fluid of erupting primary teeth . Correlations were found between cytokine levels and some of the clinical symptoms of teething: IL-1? and TNF? were correlated with fever and sleep disturbances; IL- ? was correlated with gastrointestinal disturbances and IL-1? was correlated with appetite disturbances. This observation suggests that not only must the gum pain be controlled but also gum inflammation.

Stage of development

T-go (SPHO220) has been registered a Class IIa Medical Device in the EU.

Registered

T-go (SPHO220) has the following patent numbers: EP1313489 in the European Union and US6828308 in the United States.

 

 

Marketing companies are required to sell T-go in key territories around the world.