Out-licensing

A molecular tool for studying the cell-mediated immune response. This research provides the essential markers for a guinea pig infectious disease model.  The monoclonal antibody produced against guinea pig CD8 provides an ideal non-primate animal model for several human infectious diseases, such as syphilis, tuberculosis, and chlamydial genital and ocular infection.  The guinea pig CD8 sequence information exhibits greater homology to human, canine, and feline counterparts than to rodent CD8. Researchers have cloned the full-length cDNA’s of guinea pig CD8alpha and CD8beta.   The deduced amino acid sequence of CD8alpha and CD8beta reveals characteristic structural features including a signal peptide, an immunoglobulin (Ig) variable-like region, hinge region, transmembrane, and cytoplasmic domains.  Mouse cells expressing guinea pig CD8 have been generated and will be used to produce monoclonal antibody.  Also, polyclonal antibodies have been generated against guinea pig CD8 peptides and affinity purified the antibody.  Using this antibody, the authenticity of the gene product is currently being tested. Reference:  Tissue Antigens. 2004 Feb; 63(2):184-9, Molecular characterization of guinea - pig (Cavia porcellus) CD8alpha and CD8beta cDNA. 

03-21

Not Filed

Research Tool available via non-exclusive licensing