This technology encompasses the identification of two novel genes overexpressed in senescent and Werner syndrome, human fibroblasts. Werner syndrome is a genetically determined disorder characterized by premature aging that provides a model for the study of aging. The inventors describe a cDNA whose cognate mRNA transcript is abundantly overexpressed in Werner syndrome cells and senescent fibroblasts. The S1-3 gene codes for a novel protein with 3 C2H2 type zinc finger domains, typical of the zinc finger domains present in the transcription factor SP1. The data indicate that the S1-3 cDNA clone codes for protein, which inhibits DNA synthesis. It binds to a segment of DNA whose consensus sequence is found in the origins of DNA application and overlaps a number of defined binding sites from major transcription factors including GATA-1, NF-E1, AP1 and E2A.

96-06

Patent Status: Issued # 5,905,146 License Status: Available for non-exclusive License

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