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Pharmalicensing Ltd
is a division of
UTEK Corporation
Out-licensing

Aging-related Gene - DNA Binding Protein (S1-3) (96-06)

University of Arkansas for Medical Sciences
Overexpressed in Werner's Syndrome Fibroblasts

Mechanism of action

Aging Cell Cycle and Cancer

Full description

This technology encompasses the identification of two novel genes overexpressed in senescent and Werner syndrome, human fibroblasts. Werner syndrome is a genetically determined disorder characterized by premature aging that provides a model for the study of aging. The inventors describe a cDNA whose cognate mRNA transcript is abundantly overexpressed in Werner syndrome cells and senescent fibroblasts. The S1-3 gene codes for a novel protein with 3 C2H2 type zinc finger domains, typical of the zinc finger domains present in the transcription factor SP1. The data indicate that the S1-3 cDNA clone codes for protein, which inhibits DNA synthesis. It binds to a segment of DNA whose consensus sequence is found in the origins of DNA application and overlaps a number of defined binding sites from major transcription factors including GATA-1, NF-E1, AP1 and E2A.

96-06

Development status

Preclinical

Patent information

Patent Status: Issued # 5,905,146 License Status: Available for non-exclusive License

Type of business relationship sought

Additional Licensing Partner (nonexclusive licensee) to further commericalize this patented technology

Licensing contact

Mr. Charles Cook
Licensing Associate
UAMS BioVentures - TLO
Request more information

More information

For more information about the product please visit website.

Company details

University of Arkansas for Medical Sciences
Medical School - Teaching Hospital - Research Institution

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