Beta 1, 2-Xylosyltransferase is an enzyme that adds xylose to N-linked glycoproteins. This enzyme is found in most plants but is not present in animal cells. Therefore, if animal glycoproteins are made in plants, they will have this xylose added to their oligosaccharides and may be immunogenic or allergenic. The isolation and characterization of this enzyme that contributes to the allergenicity of plant proteins will be a valuable tool for studies directed at determining the biochemical characteristics that predispose some proteins to be allergens. This discovery involves the isolation, characterization, and partial amino acid sequence of a soybean xylosyltransferase. This novel enzyme's properties are important to the study of carbohydrate structure in an economically important food crop. This unique oligosaccharide structure containing Beta 1, 2-Xylosyltransferase has been shown to be important to the allergenicity of some plant proteins and may be important to the targeting of proteins in these cells.

98-07

U.S. Patent #6,168,937

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