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Pharmalicensing
is a division of
UTEK Europe Ltd
UTEK Corporation
Out-licensing

Beta 1, 2-Xylosyltransferase - Purified (98-07)

University of Arkansas for Medical Sciences
Protein Targeting, Hypoallergenic Food Development, and Allergy

Mechanism of action

Animal Glycoproteins Made in Plants

Full description

Beta 1, 2-Xylosyltransferase is an enzyme that adds xylose to N-linked glycoproteins. This enzyme is found in most plants but is not present in animal cells. Therefore, if animal glycoproteins are made in plants, they will have this xylose added to their oligosaccharides and may be immunogenic or allergenic. The isolation and characterization of this enzyme that contributes to the allergenicity of plant proteins will be a valuable tool for studies directed at determining the biochemical characteristics that predispose some proteins to be allergens. This discovery involves the isolation, characterization, and partial amino acid sequence of a soybean xylosyltransferase. This novel enzyme's properties are important to the study of carbohydrate structure in an economically important food crop. This unique oligosaccharide structure containing Beta 1, 2-Xylosyltransferase has been shown to be important to the allergenicity of some plant proteins and may be important to the targeting of proteins in these cells.

98-07

Development status

Preclinical

Patent information

U.S. Patent #6,168,937

License Status: Available for Exclusive Licensing

Type of business relationship sought

Licensing Partner to Commercialize this patented technology

Patent number

U.S. Patent #6,168,937

Licensing contact

Mr. Charles Cook
Licensing Associate
UAMS BioVentures - TLO

Contact directly

Company details

University of Arkansas for Medical Sciences

Medical School - Teaching Hospital - Research Institution

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Industry sector
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Therapeutic target
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