Novel radiolabeled compounds for radioimaging (e.g., positron emitting tomography (PET), Computed Tomography (CT), PET/CT and Single Photon Emission Tomography (SPECT)) and/or radiotherapy. These radiolabeled compounds are designed for use in a radioimaging technique such as positron emitting tomography. keywords: fungi, PET

Active, efficacious, and non-toxic amine-borane compounds

Highlights

• Amine-borane compounds have analogous structure to naturally occurring organic compounds making them ideal candidates for therapeutic and other applications.
• Aminoboranes reduce cholesterol, are effective anti-inflammatory agents for use against septic shock, induced edema, pleurisy and chronic arthritis, and are anti-osteoporotic agents.
• Current aminoboranes are not very specific and require high doses, resulting in adverse effects and toxicity - these novel amine-borane compounds are free of these limitations.

Our Innovation

• Novel amine-borane compounds have been prepared which contain radioactive atoms and are safe for use in radio-imaging and radio-therapy. Depending on which radioactive atom is present, these compounds can be used in such imaging techniques as positron emitting tomography (PET), computed tomography (CT) single photon emission computed tomography (SPECT) or for radio-therapy.

Key Features   

• These novel compounds can be used in both therapeutic and diagnostic applications
• As opposed to other aminoboranes, they are active, efficacious and non-toxic

Development Milestones

• Cooperative relationships for the development of aminoboranes for various applications; in advanced negotiations with several companies for the development of amine cyanoboranes for topical and vaginal use

The Opportunity

• The almost $3 billion market for imaging reagents is currently led by radiopharmaceuticals for nuclear medicine imaging. The market for these reagents was over $1 billion in 2006 and is expected to grow with an average annual rate of 11.8% to surpass $1.7 billion in 2011.

project-id 9-2006-312

PCT publication number: WO 2007/032005