Immunogen: Bacterially expressed, hexahistidine amino-terminal tagged HIV-1 integrase (IN) (clade B, HXB-3 isolate)

Relevance: HIV-1 expresses the integrase (IN) protein as part of the polymerase gene. It is the viral enzyme that catalyses the insertion of viral DNA into the chromosal DNA of infected cells. Integrase is essential for viral growth and is a therapeutic target.

Tested applications: Western blots, immunoprecipation assays, immunofluorescence.

Raised in: mouse

Isotypes: IgG2bk, IgG1k

Publications: Bouyac-Bertoia et al. 2001. Molecular Cell 7:1025-35.

Gaddis et al. 2003. Journal of Virology 77:5810-20.

Patent: N/A

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