Use of substituted or modified C60 fullerenes for the prevention or treatment of thrombosis, peripheral arterial occlusion, and catheter obstruction.

This technology relates to the use of substituted or modified C60 fullerenes, which are carbon-based molecular cages that resemble soccer balls, for the prevention or treatment of thrombosis, peripheral arterial occlusion, and catheter obstruction. Described are compositions and methods for administering such compounds at the implantation site of an in-dwelling device and methods of coating in-dwelling devices with such compounds. Such devices include stents, stent grafts, pacemakers, defibrillators, venous valves, heart valves, sutures, catheters, and drug delivery ports.

Applications:
Non-invasive method of preventing clot formation.

Market:
Anticoagulation therapy averages several billion dollars a year.

Further Research Required:

• Anti-coagulant properties of C-60 derivatives in vivo
• Device coating and in vivo efficacy
• Safety evaluation of device, in vivo models

PCT Application No. PCT/US2006/041838 filed 25 Oct 2006 (HHS Reference No. E-140-2006/0-PCT-01)

Inventors:
Marina Dobrovolskaia et al. (NCI)

Licensees sought.