Summary
One of the limitations in the drug delivery field is the inability to
specifically target therapeutic or imaging agents to certain tissues,
organs or tumors. Magnetic nanoparticles have emerged as
effective drug delivery systems, which can be directed by externally
applied magnetic fields and specifically tailoring their functional
properties. Unfortunately, available magnetic nanoparticles with
therapeutic and imaging agents have several limitations: creation
involves a complex multi-step process, they have a limited agent
loading capacity, experience rapid bound agent dissociation, and
go through rapid loss of magnetization ability. Researchers at the
University of Nebraska Medical Center have developed a novel
magnetic nanoparticle technology with a high drug-loading
capacity, adjustable release profile, high aqueous dispersion
stability, biocompatibility with tissue and cells, and prolonged
stable retention of magnetic properties.

Market Value
This technology can be used to increase the efficacy, lower toxicity,
and eliminating side effects of existing and novel therapeutical
agents. An alternative market is the medical imaging sector, which
will be able to achieve more precise and rapid methods for
imaging diseases and conditions. The main competitive
advantages of the novel magnetic nanoparticles include simple
and inexpensive production, ability to effectively incorporate and
release in controlled manner wide variety of therapeutical or
imaging agents, and stable magnetic properties of complexed
nanoparticles.

Features and Benefits
• Effective drug delivery system
• Specifically target tumors and other pathological conditions
• High drug loading capacity
• A desirable release profile

Application Published US-2007-0264199-A1

(TID - 59)

UNeMed Corporation offers a variety of licensing options and collaborative development opportunities with the University of Nebraska Medical Center.