Cellophil (TM) is particularly designed for optical lenses, drug delivery and also may be used as additive for food and cosmetics or as fiber for fabrics.

Improvement of biocompatibility (tissue-, blood- and immune-response) by use of non-biodegradable biophilic biomaterials.

Cellophil™ is a group of polyacryloyl-alpha-aminoacids that show superior biocompatibility in comparison to polymers currently used in biomedical applications such as PMMA, MMA, HEMA and the like. Cellophil ™ polymers are non-biodegradable, non-immunogenic, amphoteric and are highly tissue-, blood- and cell-compatible. We have designed different Cellophil™ amino-acid structures based on lysine, serine, tyrosine, cysteine, hydroxypoline and threonine and combined them in different rates with acrylics. Doing so, we control chemical and physical characteristics of the final product, such as hydrophilicity, hydrophobicity, water content, porosity and pore structure, optical clarity, adhesive properties, surface texture, permeability and other mechanical properties. Whatever the composition/property of the Cellophil™ polymers, they are highly biocompatible.

Biocompatibility was shown in-vitro by measuring the confluence of differentiating cells. Comparing the confluence data of Cellophil™ to currently available polymers we show that Cellophil™ polymers are far superior to HEMA, PMMA, MMA etc. The biocompatibility is as high as collagen, the natural human polymer (control).

Cellophil™ polymers improve the acceptance of many implants and medical devices. The healing process may be shortened and mechanical properties be optimized for a safer use. Cellophil™ polymers create new applications of polymers as biomedical devices.

Ophthalmology: Contact Lenses, Intraocular Lenses, Drug Delivery, Synthetic Cornea

Cosmetic / Reconstructive: Breast Implants

Orthopaedic: Osteosynthesis, Intervertebral Disks, Tendons

Cardiopulmonary / vascular: Blood Vessels, Heart Valve

Otorhinolaryngology: Ear Drums

Dermatology: Woundcare, Artificial Skin

Gastroenterology: Artificial Colon Structure

Dental: Fillings, Osteosynthesis

Renal-Urological: Catheder

Medical Devices: Surgical Threads, Delivery Systems

In addition to many applications in the field of implants and medical devices Cellophil™ is particularly designed for optical lenses, drug delivery and also may be used as additive for food and cosmetics or as a fiber for fabrics.

A special focus of our approach is the use of Cellophil™ to deliver drugs to the targeted site. Drugs applied might be charged positive or negative or can be aromatic without charges. With a special technique we load Cellophil™ matrices and control the release of the compound.

Preclinical

Patent application pending, US 60/684,175

With regards to Cellophil we are looking for partners with a strong (polymer) development and sales platform. With established proof of concept Cellophil's physical and chemical properties are to be tailored to the specific needs of the application. We provide GMP-manufacturing of monomers as well as regulatory support for DMF filing.