1,2,4-benzothiadiazine derivatives useful for the treatment of endocrinological system diseases such as hyperinsulinaemia and diabetes.

Potassium channels play an important role in in the control of membrane potential. Among the different types of potassium channels are the ATP-sensitive potassium channels (KATP-channels) which are regulated by changes in the intracellular concentration of adenosine triphosphate. The KATP-channels have been found in cells from various tissues such as cardiac cells, pancreatic ß-cells, skeletal muscle cell, smooth muscles cells, central neurons and adenohypophysis cells. Modulators of the KATP-channels have been found to be of importance for the treatment of various diseases. The 1,2,4-benzothiadiazine derivatives interact with the potassium channels and hence act as openers or blockers of the ATP-regulated potassium channels. These derivatives are useful in the treatment of various diseases of the cardiovascular system, e.g. cerebral ischemia, hypertension, ischemic heart disease, angina pectoris and coronary heart diseases; the pulmonary system ; the gastrointestinal system ; the central nervous system and the endocrinological system Potential applications : The 1,2,4-benzothiadiazine derivatives can enter in pharmaceutical composition for therapeutic use in the treatment of diseases of the endocrinological system, such as hyperinsulinaemia and diabetes

Early Stage

WO 97/49692 A1

Research collaboration for license agreement.