Robotized portable device for the detection of contaminants
Robotized portable system to analyze multiple samples that allows the simultaneous detection of up to thousands different analytes in a single test. It can be applied to environmental and medical sectors, for the detection of contaminants, microorga
Mechanism of action
The system uses a technology similar to the DNA and proteins microarrays technology, but the sample treatment for the analysis is substantially reduced, and the whole process is robotized.
Full description
A group of researchers has developed a portable system that
allows
the analysis of multiple samples and the detection and
simultaneous
characterisation from tens to thousands different analytes
in a single
test. This system is liable to remote control handling. It
takes
advantage of the recent technology of DNA and proteins
microarrays,
that has increased the analysys capability and the detection
sensitivity
enormously, providing studies of biological, biomedical and
biosanitary problems. Far from the technologies based on
microarrays, in the current technology the sample treatment
for the
analysis is substantially reduced, and the whole process is
robotized.The apparatus comprises a series of operating
modules, in
which the samples are manipulated, treated and analized, and
a series
of controlling modules that control the operating ones.
Samples to be analyzed can be at liquid or solid state, or
even in
suspension. For its homogenization an homogeneous mixture is
formed between the sample and a salt solution or buffer, in
order to
disgragate the particulates extremely and to solve the
analytes.
Laterly, the homogenized sample is subjected to different
processes:
chemical, biochemical and biological change, or physical
modifications like filtration, concentration, etc. The
result of the
processing can be the molecular marking of the analytes in the
sample. This molecular marking consists in a fluorescent
substance or
any other agent that enables the posterior identification of
the modified
analyte.Once the sample has been processed, it gets in
contact to a
sensor constituted by one or more substances able to
interact with
analytes in the sample. The final object is the detection of
the analytes
which are bounded into the sensor. To do so, a series of
devices for
the marked analytes detection is provided. If these analytes
have
been modified by a fluorescent substance (fluorochrome), a
radiation
source to excite the fluorochrome and a fluorescence
detector are
provided. Detected data are processed by a software that is
prepared
to provide a final submission of results by means of a
"bits" map which
originates an image susceptible to be computerized, either
by the data
reading module software or by a remote station.
Innovative aspects:
-This technology is allowed to detect certain substances and
to infere
its possible toxicity or patogenicity properties by means of
systems
based on molecular properties of bions.
-It's able to detect from several substances up to thousands
of them by
a single test, mainly components with biological origin.
-It's a widely autonomous system.
-It's able to analyze multiple samples.
-It's capable to process liquid samples (body fluids or
water) or
suspensions (of ground, sediments or crushed rockes) which
volume
ranges from micro to mililiters.
This technology has been developed and is available for
demonstration.
Patent information
Patent applied for but not yet granted.
Type of business relationship sought
License agreement and manufacturing agreement.