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Tackling challenges of poor solubility
Enhancing the dissolution performance of small and large molecules in a range of dosage forms
Mechanism of action
Supercritical fluid (SCF) particle and crystal engineering (intimate composites and single agent)
Full description
With over 40% of new drug substances exhibiting poor aqueous solubility, a major task has been to explore potential alternative procedures for overcoming this undesirable and problematic characteristic.
Poor solubility can greatly compromise the bioavailability of a drug, and thereby detract from optimising the clinical efficacy of these promising candidates. With supercritical fluid processing, micron- and sub-micron sized, particles with morphologies giving high surface areas can be readily produced. These provide the opportunity to maximise particle dissolution rate, and optimise dosage forms for these previously challenging molecules.
The Crystec team also have the capability to engineer composite particles, potentially incorporating enhancer molecules which can help to overcome notoriously difficult obstacles such as the blood-brain barrier, or to stabilise amorphous forms.
Development status
Phase I/II
Patent information
CrystecPharma's intellectual property strategy is to protect products, maintaining its technology platform and scale-up expertise as a trade secret.
Type of business relationship sought
We are keen to work with companies developing small and large molecule therapeutics, facing challenges of poor bioavailability.
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Licensing contact
Company details
CrystecPharma
CrystecPharma applies the latest supercritical fluid (SCF) technologies to improve the design and performance of medicines
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