Out-licensing

Compositions and Methods for Characterizing and Regulating Olfactory Sensation

Introduction/Background

The sense of smell is critical to determining the flavour of foods and beverages, the ability to avoid environmental danger, and stimulation of sexual response.

Aims/Hypothesis

This research is focused on providing a system and method to screen for modulators of scent perception.

Results

Researchers at Duke University Medical Center have identified a human odorant receptor, OR7D4, which is selectively activated by the odorous steroids androstenone and androstadienone, compounds that are thought to affect the mood and physiological state of women and men. Common genetic variants of this receptor have been discovered and exhibit altered activation capacity. This technology provides assays for detection of these variations and methods of screening for ligands and modulators of olfactory sensation.

Conclusion

This invention deorphanizes a receptor responsible for perception of known pheromones androstenone and androstadienone and demonstrates that odour perception is linked to genetic variations. Importantly, it provides methods to screen for compounds that could modulate an odorant receptor's activity and, in turn, olfactory sensation and sexual response.

Relevance/Opportunity

Duke University is seeking a corporate partner to further develop and commercialize technology related to the regulation of olfactory perception. Please enquire quoting reference no. 2778 regarding licensing or codevelopment partnerships.

Preclinical