Out-licensing

A Novel Systems Biology Approach to Identify Subtle Disease Including Prediabetes Mellitus

A method has been developed for assessing an inter-dependent biological system wherein said methods comprise determining by using a systems biology approach whether a set comprising at least three variables is within a diagnostic coordinate range (normal) or outside a diagnostic range (abnormal). As an example, methods were developed to detect and quantify the earliest stages of regulatory failure in nondiabetic individuals who may be at increased genetic or environmental risk for type II diabetes mellitus (DM) by analytically reconstructing pathways that mediate time-varying regulation of a minimal triad of interlinked signals, viz., glucose, insulin and glucagon. These methods can allow for the quantification of ensemble dynamics, rather than the behaviour of any one signal, by estimating endogenous dose-response pathways non-invasively without using radiolabeled or otherwise marked molecules in awake, unmedicated, healthy individuals, given only sparse and noisy measurements of the three signals.

Conclusion

We have developed a novel approach to identify subtle diseases, including prediabetes mellitus.

Relevance/Opportunity

Please enquire quoting reference no. 2006-137 regarding licensing or codevelopment partnerships.

Preclinical