Use of substituted or modified C60 fullerenes for the prevention or treatment of thrombosis, peripheral arterial occlusion, and catheter obstruction. More
Direct thrombin inhibitors designed for improved safety/efficacy profile. Peptide inhibitors suitable for cost-effective recombinant production.Anti-thrombin peptides that can be fused to homing peptides for targeted delivery or fused to markers. More
Retractable inhibitors controlled through polypeptide-protein interactions with the flexible peptide bridge that link the two binding fragments may represent an alternative approach to antidote-reversible anticoagulant therapy. More
Lead Inventors: Thomas Diacovo, Jianchun Chen Problem or Unmet Need: One major hurdle hindering antithrombotic drug development is the lack of an appropriate small animal model of thrombosis to test promising therapies, as in vitro models of thrombosis... More
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