Inventors at the National Institutes of Health have recently characterized and cloned both the yeast and human recombinant versions of the enzyme deoxyhypusine hydroxylase (DOHH) that catalyzes the final step in the modification of eIF5A. More
These analogs were found to be potent inhibitors of IGF-1-mediated cell signaling and cancer cell growth, providing more binding specificity with less likelihood of significant toxic effects. More