Topical application of DKK1 to non-palmoplantar skin induces the development of increased skin thickness, decreased pigmentation, and decreased hair growth. More
These mice manifest the same defects seen in people afflicted by autosomal recessive ichthyosis with hypotricosis so it can be an effective model for studying the role of matriptase in disorders that affect skin development. More
The compounds, peptides and nucleotides, are useful for the treatment of diseases such as premature aging syndromes, dyskeratosis congenita, neurodegenerative diseases, cancer and other pathologies. More