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Companies

Yeda R&D Co. Ltd

Yeda R&D Co. Ltd
Yeda R&D Company Ltd. is the Technology Transfer Company of the Weizmann Institute of Science. Yeda markets and commercializes intellectual property created at the Weizmann Institute laboratories

The company in detail

Profile

Yeda Research and Development Company Ltd. is responsible for technology transfer from the Weizmann Institute of Science (WIS), Israel's leading center of research and graduate education. WIS activities range across the spectrum of contemporary science. Yeda initiates and promotes the transfer to the global marketplace of research findings and innovative technologies developed by WIS scientists. Established by WIS in 1959, YEDA is one of the world's first and most successful technology transfer organizations, and demonstrated an impressive track record in promoting the commercial development of WIS research studies. Yeda performs the following activities:

• Identifies and assesses research projects with commercial potential.

• Protects the intellectual property of the Institute and its scientists.

• Licenses the Institute’s inventions and technologies to industry.

• Channels funding from industry to research projects

Proprietary Technology:

Inventions from the Weizmann Institute of Science include therapeutics (peptides, proteins, antibodies, small molecules, RNA-based therapies, aptamers, stem cells), diagnostics, enabling technologies, novel targets and research tools and extending to biofuels and systems biology.

Intellectual Property Status:

Yeda Statistics:

• Over 100 patent disclosures submitted by WIS scientists.

• Over 1500 patent families filed since 1971

• Over 600 live patent families.

• Over 40 new license and option agreements signed in 2008.

Out-licensing

By measuring the changing capacitance of each molecule as it flows through a measuring device, its' exact motion path can be measured accurately with sub-micrometer spatial resolution and millisecond time-scales, rather than relying on existing methods... More
A novel drug delivery system for nail infections.Infections of foot and hand nails by fungi are a very common condition in millions of people. They account for about half of all nail disorders and are estimated to occur in over 10% of the population.... More
A synthetic peptide immunomodulator designed to treat Systemic Lupus Erythematosus (SLE). SLE is a chronic, disabling and potentially life-threatening autoimmune disorder that involves multiple organ systems including the skin, joints, heart, lungs,... More
A novel therapy for the suppression of cancer metastasis onset.Metastasis, the spread of tumor cells from the primary site to distant organ environments, is the leading cause of death from cancer. A key turning point in the course of cancer progression... More
Recording the distribution (wash-in, wash-out) of MRI contrast material at different time points increases the specificity of MRI cancer diagnosis. Contrast material distribution is affected by tumor cellularity and microcirculation. More
The invention relates to reversible-pegylated catecholamines, particularly PEG5-Fmoc-epinerhrine, that may be used for enhancement of repopulation of hematopoietic stem/progenitor cells (HSPC) in the bone marrow of individuals who have undergone... More
Novel peptide sequences identified from breast, prostate, and bladder cancers are utilized as targets for anti-tumor vaccines. Local therapy such as surgical exicision or ablation by radiation is a mainstay for the treatment of primary cancer and is... More
A novel T-cell targeted therapy for inflammatory and autoimmune diseases.Therapeutically controlling inflammation is essential for the clinical management of many high-prevalence human diseases. Inflammatory diseases represent a major burden on humanity,. More
An adjunctive diagnostic tool for prostate cancer accurately maps Zn concentration and distribution in prostate tissue, as lower concentrations may indicate malignancy. This tool increases the specificity and sensitivity of current diagnostic testing,... More
A new cell-based drug discovery platform.Conventional drug discovery remains a complex and expensive process, where a drug target associated with a particular disease is identified, then a specific assay is developed to monitor changes in this target... More
A simple system for diagnosing the state of a cell. The state of a cell can be diagnosed by monitoring the activity patterns of its various pathways. In most cases it is essential to monitor the activity of several genes in order to accurately determine.. More
Ultrashort laser pulses lasting only a few femtoseconds, replacing older methods for Raman spectroscopy, achieve high-resolution intracellular and extracellular spectroscopy goals in a cost-effective manner. Spanning the entire vibrational energy range,.. More
A novel compound for the treatment of the metabolic syndrome.The metabolic syndrome is defined as a constellation of factors associated with increased risk for cardiovascular disease and diabetes, including obesity, hyperglycemia, hypertriglyceridemia... More
A novel approach for both local and systemic treatment of cancer.Malignancies such as lung and skin cancer represent a large group of highly debilitating and/or lethal diseases constituting a primary cause of death, and an enormous social and economic... More
A method for both induction and inhibition of cell migration.Cancer is the second leading cause of death in the US, accounting for almost 23% of all deaths (as of 2008), and with an estimated total medical costs of $210 billion (as of 2005). ... More
Strategies that allow drugs to remain active after penetrating the blood-brain barrier. Disorders of the central nervous system (CNS) (e.g. Alzheimer's disease) constitute an increasing market that reached total sales of $77.3 billion in 2007. Many... More
A comprehensive analysis of enzymes has shown that catalytic residues are often found among the 5% of residues closest to the enzymic centroid. A new method for identifying and analyzing the active sites and catalytic residues of new enzymes measures the. More
A quick and efficient enzymatic method to detect SNPs. The 0.1% variability between the genomes of two individuals consists mostly of single base pair differences at definite locations called single nucleotide polymorphisms or SNPs. A study of this... More
A novel biomarker for schizophrenia Schizophrenia is a severe mental disorder that affects about 1% of the world population. As the underlying genetic and neuronal abnormalities in schizophrenia are largely unknown, it is challenging to measure the... More
A simple method to diagnose Alzheimer's disease. Alzheimer’s disease (AD) is the most common human neurodegenerative disease, leading to progressive decline in cognitive functions and death. In the U.S., 5.2 million people suffer from AD, generating an... More
A reliable method for detection of atherosclerosis.Atherosclerosis is responsible for more deaths in the U.S. than any other condition. Unfortunately, atherosclerosis produces no symptoms until the damage to the arteries is severe enough to restrict... More
An innovative high-throughput system for the automated tracking of protein dynamics in living cells.Cellular imaging is emerging as a crucial tool that would enable the integration of biological complexity into drug discovery. To better understand how... More
A method for detecting and inhibiting various cancers. Kidney, intestine and lung cancers account together for approximately 28% of the total cancers in the U.S., and even more in deaths (as of 2008). Therefore, early detection of these cancers is highly. More
A novel, lymphocyte-based treatment for autoimmune and inflammatory diseases.Inflammation-based disorders include a wide range of diseases such as autoimmune diseases, graft rejection, graft versus host syndromes and inflammation induced malignancies.... More
A simple method to localize endogenous mRNAs in vivo.Local mRNA translation is involved in a variety of basic cellular processes (cell-fate determination, cell polarization, etc.). Furthermore, defects in mRNA translation may lead to human diseases.... More
Researchers at the Weizmann Institute have developed Genomica, a statistical analysis and visualization tool that integrates any type of genomic data, with the aim of facilitating biological discoveries. Genomica contains a suite of tools that... More
Bladder cancer is a common malignancy; it is the 4th most common cancer in males and the 9th in females.  The presenting symptom is usually blood in the urine, and diagnosis is currently based on cystoscopy, which is invasive, costly, painful and... More
A non-invasive diagnostic test to identify individuals with increased risk of lung cancer.Lung cancer is one of the most common cancers and considered to be the leading cause of cancer deaths in the western world, accounting for nearly 30% of all cancer.. More
Peptides for efficient translocation of compounds in and out of the cell nucleus. The ability to regulate cellular localization of a biological component is important for many functions such as gene therapy, protection from toxic chemicals and transport.. More
Identification of microRNA interactions and microRNA-transcription factor interactions can illuminate the little known field of microRNA regulation on genetic expression. More
An innovative method for the design of HIV-1 vaccines.AIDS is the fourth major cause of death worldwide. More than 60 million people worldwide have been infected with HIV-1, since it was identified as the causative agent for AIDS, and nearly half of... More
A method to improve chemotherapy in treating colon cancer patients.Colon cancer is the second leading cause of death from cancer in the United States, with about 112,000 people diagnosed annually. Treatment options may include surgery and/or... More
Karet is a new molecule which is capable of interacting with TrkA in neural cancer cells and inducing TrkA dependent cell death. Novel and optimal treatments are urgently required for treatment of cancers of neural origin, in particular pediatric tumors.. More
Novel compounds for site-directed chemotherapy.Chemotherapy constitutes one of the major therapeutic approaches for the treatment of cancer, along with surgery and radiotherapy. Many of the shortcomings of currently approved anti-cancer drugs are a... More
The analysis of somatic mutations accumulated during development can be used to map cellular lineage trees for higher organisms such as mice and humans. These mutations can be used to reconstruct a lineage tree with no errors, and may be useful in cancer. More
Analyzing networks (such as social, internet, IT etc.) by a method based on genetic networks. Breaking down protein-gene relationships into network motifs – structures that appear more than expected – may assist in deciphering ties between the... More
A method for the diagnosis and treatment of neurological damage. Numerous methods of treatment of human neurologic damage exist, in particular methods for increasing regeneration and repair of damaged neurons and nerve axon myelin coatings have been... More
Delivery of contrast material to tumor cells can be compromised by the abundance of perivascular stroma myofibroblasts that hinder transfer of materials from the vessels to the tumor cells. Evoking an alternate competing endocytic pathway using a novel... More
Design of improved compounds to treat heart failure.Heart failure is a serious condition which includes about 5 million people in the U.S., and results in about 300,000 deaths each year. Cardiac glycosides (CG) such as digoxin or digitoxin have been used. More
A potential target for anticancer drug design. Cancer is the second leading cause of death in the US, accounting for almost 23% of all deaths (as of 2008), and with estimated total medical costs of $210 billion (as of 2005). Despite major advances in the. More
Improved compounds for treatment of cancer and other estrogen related diseases. Cardiovascular diseases and cancer are the leading causes of death in the U.S., accounting for almost 50% of all deaths (as of 2005). Many types of cancers are estrogen... More
A new, non-invasive method for measuring fluid flow and other parameters using perpendicularly-aimed ultrasonic waves eliminates the inaccuracies of skewed beam measurements, is indifferent to pipe/vessel material as well as to particles in the fluid,... More
Oleyl alcohol with anti-inflammatory effects that may be chemically tailored for particular medical applications.Anti-inflammatory agents that modulate the inflammatory response were found to be effective in a wide variety of pathological conditions.... More
Immune tolerance to partially mis-matched donors is an urgent unmet need in transplantations. Scientists at WIS have shown that this could be achieved by unique protocols for positive and negative selection of specific immune cell populations for... More
Rheumatoid Arthritis patient need to undergo treatment which in many cases is not efficient and accompanied by various side effects. WIS reaearchers showed that Rheumatoid Arthritis may be treated by short peptides derived from Heat Shock Protein 60... More
Ultra short, 100-300 millisecond exposure to conventional X-rays and rotating anodes can be inexpensively used to achieve highly-reproducible protein-nucleic acid portraits, replacing the need for complicated, expensive use of Synchrotron Radiation and... More
A simple, single-step biochip platform for synthesis of biomolecules. Biochip technology, which is used today for measuring only passive probe-target interactions (such as measuring the abundance of specific biomolecules), can be extended to include... More
 A novel method for treating or preventing both over and underweight disorders and related diseases. Obesity represents the most prevalent of weight disorders affecting 30-50% of the middle aged population of the western world, with health costs... More
Embryonic cells for transplantation of various tissues. As the number of people awaiting organ transplantation exceeds the availability of human organs, mortality rates due to lack of donated organs increase yearly. New solutions to increase the... More
An enzyme with improved anti-atherosclerotic and detoxiftying activities. The enzyme Paraoxonase 1 (PON1) resides on HDL in the blood. The levels of PON1 and its catalytic proficiency appear to have a major impact on susceptibility to atherosclerosis,... More
A new "language" which allows for compatibility between systems/complex processes such as exist in life sciences/aerospace and the front-end of currently available, widely-used animation platforms. This new technology can successfully convey and... More
New protein as a target to treat B cell-related cancer.Chronic lymphocytic leukemia (CLL), a malignant disease characterized by the accumulation of B lymphocytes in the blood, lymphoid organs, and bone marrow, is the second most common type of leukemia... More
Proteins for treatment of demyelinating disorders.Demyelinating disorders (e.g. multiple sclerosis), i.e. conditions characterized by the destruction of the myelin sheaths of the nerves, are severe diseases that require prolonged hospitalization and may.. More
Using ultrasonic waves of varying wavelengths enables a continuous process of size separation or particle removal from solutions or biomass which does not damage the separated substance. This new technology allows for this process to take place in... More
A team of researchers at the Weizmann Institute have demonstrated that human and rabbit spermatozoa are able to sense the temperature difference that exists at ovulation between the fertilization and storage sites in the oviduct and respond to it by... More
A method to enhance the binding of proteins to their target DNA. During cell division and differentiation many nuclear proteins are involved in metabolizing genomic DNA in various vital processes, such as replication, transcription, repair and... More
A method for diagnosis and treatment of splicing related pathologies.Alternative splicing, a process by which one gene can generate multiple mRNA isoforms and then several proteins, is a major contributor to the functional diversity of the human... More
A new method for controllable, reversible pegylation of protein drugs allows for longer serum half life and continuous slow hydrolysis which releases the peptide in its active form, thereby extending the bioavailability and efficacy of protein drugs. More
Algae and certain types of bacteria use CO2 for photosynthesis and are prime sources for biomass for bio-fuel production. By genetically altering proteins which participate in photosynthesis, these species can efficiently conduct this process in both... More
Compounds for the treatment of neurodegeneration.Neurodegenerative disorders progressively destroy the mental capacity and motor control of afflicted patients. Despite intense worldwide efforts, no disease-modifying therapies for such disorders exist and. More
Methods for the detection and treatment of chronic inflammatory disorders.Chronic inflammatory diseases afflict millions of people across the world leading to considerable suffering, economic loss and premature death. These diseases include inflammatory.. More
A conjugate of alliinase, the garlic derived enzyme, and a target-specific antibody is administered systemically followed by alliin, the enzyme’s substrate. Consequently, Allicin, the active substance, is synthesized in-situ at the antibody-targeted... More
A non-invasive method to diagnose breast cancer. Breast cancer is the second most commonly diagnosed cancer among U.S. women, with a 13% incidence. The use of screening tests for early detection of breast cancer and other cancers provides better... More
A unique immune-based therapy to treat psychological disorders.Psychological disorders (e.g. schizophrenia, depression, etc.) are among the most prevalent diseases of humankind. These disorders affect approximately 16% of the U.S. population age 18 and... More

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Contact details

Shiraz Kalir
Licensing Officer

Contact directly

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Head office

Yeda R&D Co. Ltd
Weizmann Institute of Science
P.O Box 95
Rehovot
76100
Israel

Company figures

Formed: 1959

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