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CrystecPharma
CrystecPharma applies the latest supercritical fluid (SCF) technologies to improve the design and performance of medicines
The company in detail
Profile
CrystecPharma provides particle and crystal engineering solutions to the pharmaceutical and biopharmaceutical industries, contributing to human health by enabling new and more effective therapies. This is achieved through the application of the latest supercritical fluid (SCF) technologies, and the integration of cutting edge developments in the field into our work.
Crystec's services include crystal form screening and particle design, addressing issues of poor solubility and stability, improved and new routes of delivery (e.g.inhaled/nasal) and improved performance in support of product lifecycle management (LCM) and product development programmes. Our technologies can be applied to small drug molecules and also to macromolecules in a range of dosage forms. We have enjoyed widespread success in the projects we have undertaken in these areas.
Our proprietary technology and extensive knowhow allow us to provide support in many areas, including:
- Crystal and particle engineering for targeted delivery and enhanced product performance
- Stabilisation and rapid reconstitution of biotherapeutics
- Uniform composite particles, for single particle combination therapies (attractive for co-deposition of API's in respiratory drug delivery) or for co-formulation with enhancer molecules (to facilitate membrane transport)
- Formation of pure metastable forms that have enhanced solubility and which demonstrate improved chemical and physical stability
- Faster onset of action
- Potential to reduce the dose with equivalent levels of bioavailability
- Improved inhaled / nasal delivery through optimised particle design
After an in-depth review with our clinical advisor and consultants we have various in-house and collaborative programmes underway to develop improved therapeutic products with a focus on meeting unmet clinical needs. Our current programme includes projects in malaria, fungal infections, endometriosis, COPD, dyslipidaemia and pain.
Crystec is open to collaboration on product development, on a risk sharing basis, where appropriate.
Partnering strategy/interests
Crystec engages in contract and collaborative research, as well as licensing products, proprietary technology and intellectual property in solid state pharmaceutical materials. We are actively seeking clients working with challenging large and small molecule therapeutics who are seeking to achieve improved bioavailability, enhanced stability or require a new route of delivery.
The Crystec team consists of the some of the world’s leading scientists in the field of supercritical fluid technology based pharmaceutics, including Professor Peter York. The team has more than sixty years of experience in the field.
Members of the Crystec team were responsible for the design and development of the world's first supercritical fluid (SCF) engineered drug, an inhaled fast-onset treatment for migraine, which recently filed its NDA and is expected to launch this year. This is a drug that was taken from an intravenous (IV) route of delivery to inhaled, with equivalent levels of activity using SCF processing.
Out-licensing
Related Reports
Contact details
Miss Catherine Hunter
Business Development Manager
Head office
Crystec Ltd
Institute of Pharmaceutical Innovation
Bradford
West Yorkshire
BD7 1DP
United Kingdom
Company figures
Related categories
- Industry sector
- Biotechnology
- Drug delivery
- Pharmaceutical
- Therapeutic target
- Metabolism / Weight loss
- Accident and Trauma / Back Pain
- Accident and Trauma / Stroke/traumatic brain injury
- Allergy
- Allergy / Allergic rhinitis (hay fever)
- Allergy / Allergies (other)
- Allergy / Allergy, ophthalmic
- Allergy / Allergy, skin
- Cardiovascular / Anticoagulants
- Cardiovascular / Blood clotting
- Cardiovascular / Anemia / Anemia, sickle cell
- Cardiovascular / Anemia / Hemolytic anemia
- Cardiovascular
- Cardiovascular / Acute coronary syndromes / Angina
- Cardiovascular / Cardiovascular disorder (other) / Diabetic cardiovascular disease
- Cardiovascular / Cerebrovascular disorders / Aneurysm
- Cardiovascular / Thrombotic disorders / Pulmonary embolism
- Cardiovascular / Thrombotic disorders / Thrombosis
- Cardiovascular / Vascular / Atherosclerosis
- Cardiovascular / Vascular / Hypertension
- Cardiovascular / Vascular / Hypotension
- Central Nervous System
- Central Nervous System / Age-related disorders (other)
- Central Nervous System / Amyotrophic lateral sclerosis
- Central Nervous System / Pain / Pain management general
- Central Nervous System / Pain / Pain, acute
- Central Nervous System / Pain / Pain, AIDS-related
- Central Nervous System / Pain / Pain, back upper/lower
- Central Nervous System / Pain / Pain, cancer
- Central Nervous System / Pain / Pain, chronic
- Central Nervous System / Pain / Pain, inflammatory
- Central Nervous System / Pain / Pain, neuropathic
- Central Nervous System / Psychiatric / Addiction
- Dermatological / Acne
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- Dermatological / Male pattern baldness
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- Dermatological / Ulcer, diabetic
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- Endocrinology / Amenorrahea
- Endocrinology / Androgen deficiency
- Endocrinology / Endocrine system
- Endocrinology / Estrogen replacement
- Endocrinology / Hormone replacement therapy
- Endocrinology / Hypogonadism
- Endocrinology / Hypothalamic
- Endocrinology / Menopause
- Endocrinology / Pancreatic exocrine insufficiency
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- Gastrointestinal / Dyspepsia
- Gastrointestinal / Emesis
- Gastrointestinal / Emesis, motion
- Gastrointestinal / Esophagitis
- Gastrointestinal / Flatulence
- Gastrointestinal / Gastritis
- Gastrointestinal / Gastroesophageal reflux disorder
- Gastrointestinal / Gastrointestinal (other)
- Gastrointestinal / Gastrointestinal secretions
- Gastrointestinal / Inflammatory bowel disease
- Gastrointestinal / Helicobacter pylori
- Gastrointestinal / Irritable bowel syndrome
- Gastrointestinal / Nausea
- Gastrointestinal / Pancreatitis
- Gastrointestinal / Ulcer
- Genito-urinary
- Metabolism / Cirrhosis
- Genito-urinary / Gender related medicine female / Amenorrhea
- Genito-urinary / Gender related medicine female / Contraception, female
- Genito-urinary / Gender related medicine female / Dysmenorrhea
- Genito-urinary / Gender related medicine female / Dysoplasia, cervical
- Genito-urinary / Gender related medicine female / Endometriosis
- Genito-urinary / Gender related medicine female / Female arousal disorder
- Genito-urinary / Gender related medicine female / Menopause
- Genito-urinary / Gender related medicine female / Pelvic inflammatory disease
- Genito-urinary / Gender related medicine female / Pregnancy
- Genito-urinary / Gender related medicine male / Benign prostatic hypertrophy
- Genito-urinary / Gender related medicine male / Contraception, male
- Genito-urinary / Gender related medicine male / Male erectile dysfunction
- Genito-urinary / Gender related medicine male / Male Premature Ejaculation
- Genito-urinary / Gender related medicine male / Prostatitis
- Genito-urinary / Genito-urinary other / Candidiasis
- Genito-urinary / Urinary / Diabetic nephropathy
- Genito-urinary / Urinary / Diuretic
- Genito-urinary / Urinary / Incontinence
- Genito-urinary / Urinary / Interstitial cystitis
- Genito-urinary / Urinary / Renal disease
- Genito-urinary / Urinary / Renal failure
- Genito-urinary / Urinary / Urinary incontinence/urgency
- Genito-urinary / Urinary / Urinary tract disorder (other)
- Genito-urinary / Urinary / Urinary tract infection
- Hospital and Surgery / Bleeding
- Hospital and Surgery / Fibrosis
- Immune related disorders / Chronic fatigue syndrome
- Immune related disorders / Gout
- Immune related disorders / HIV/AIDS
- Immune related disorders / Lupus erythematosis
- Immune related disorders / Rheumatoid arthritis
- Infectious diseases
- Infectious diseases / Parasitic diseases
- Infectious diseases / Parasitic diseases / Infection, parasitic
- Infectious diseases / Bacteria or virus / Candida
- Infectious diseases / Bacteria or virus / Cytomegalovirus
- Infectious diseases / Bacteria or virus / Ebola virus
- Infectious diseases / Bacteria or virus / Escherichia coli
- Infectious diseases / Bacteria or virus / Haemophilus influenzae
- Infectious diseases / Bacteria or virus / Hantavirus
- Infectious diseases / Bacteria or virus / Helicobacter pylori
- Infectious diseases / Bacteria or virus / Herpes simplex virus
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- Infectious diseases / Bacteria or virus / Parainfluenza virus (Type 3)
- Infectious diseases / Bacteria or virus / Pertussis
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- Infectious diseases / Bacteria or virus / Respiratory syncytial virus RSV
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- Infectious diseases / Diseases / Bronchitis
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- Infectious diseases / Diseases / Sepsis
- Metabolism
- Metabolism / Anti-oxidant
- Metabolism / Cachexia
- Metabolism / Diabetes type I
- Metabolism / Diabetes type II
- Metabolism / Diabetic complications
- Metabolism / Hypercholesterolemia
- Metabolism / Hyperparathyroidism
- Metabolism / Hypertriglyceridemia
- Metabolism / Liver cancer
- Metabolism / Mineral supplement
- Metabolism / Obesity
- Musculoskeletal
- Musculoskeletal / Back pain
- Musculoskeletal / Dyskinesia
- Musculoskeletal / Gout
- Musculoskeletal / Lupus erythematosis
- Musculoskeletal / Intermittent claudication
- Musculoskeletal / Muscular / Inflammation
- Musculoskeletal / Skeletal / Arthritis (non-specific)
- Musculoskeletal / Skeletal / Rheumatoid arthritis
- Oncology
- Oral Health / Aphthous ulcers
- Oral Health / Gingivitis
- Oral Health / Gum disease
- Oral Health / Herpes simplex virus type 1 (oral)
- Oral Health / Mucositis oral
- Oral Health / Periodontal disease
- Other therapeutic / Chinese medicine
- Respiratory
- Respiratory / Allergy, respiratory
- Respiratory / Asthma
- Respiratory / Asthma, bronchospasm
- Respiratory / Bronchitis
- Respiratory / Chronic obstructive pulmonary disease
- Respiratory / Cough
- Respiratory / Cystic fibrosis
- Respiratory / Emphysema
- Respiratory / Obstructive airway disease
- Respiratory / Respiratory syncytial virus
- Respiratory / Respiratory tract infections
- Respiratory / Rhinitis
- Respiratory / Rhinovirus (common cold)
- Respiratory / Sinusitis
- Respiratory / Tuberculosis
- Sensory organ
- Sensory organ / Auditory
- Sensory organ / Auditory / Otitis media
- Sensory organ / Opthalmic / Cataract
- Sensory organ / Opthalmic / Conjunctivitis
- Sensory organ / Opthalmic / Corneal ulcer
- Sensory organ / Opthalmic / Diabetic retinopathy
- Sensory organ / Opthalmic / Dry eyes
- Sensory organ / Opthalmic / Glaucoma
- Sensory organ / Opthalmic / Hyperopia
- Sensory organ / Opthalmic / Macular degeneration
- Sensory organ / Opthalmic / Retinopathy
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