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Ramot At Tel-Aviv University Ltd
Ramot at Tel Aviv University Ltd, is the technology transfer company of Tel Aviv University (TAU).
The company in detail
Profile
Ramot at Tel Aviv University Ltd, the technology transfer company of Tel Aviv University (TAU), is dedicated to helping transform laboratory innovations to commercial products, quickly and efficiently.
Ramot is TAU's point of entry for potential industrial partners seeking to access TAU's research enterprise, technology pipeline and intellectual property portfolio.
Since it was founded in 1973, Ramot has helped numerous companies and investors harness the sophisticated discoveries of TAU’s world-renowned scientific researchers. Today, it continues to serve as an effective bridge between TAU’s leading scientists and companies looking for a technological edge in their marketplace.
Ramot manages all activities relating to the protection and commercialization of inventions and discoveries made by faculty, students and other researchers of TAU.
Partnering strategy/interests
Ramot seeks partners to commercialize the discoveries generated at Tel Aviv University.
Ramot emphasizes bridging the "development gap" - the gap between the basic science that TAU excels at, and the mature technology that industry looks for. Ramot has introduced unique processes and programs for bridging this gap. As a result, industry partners find Ramot to be a source of technologies that are both scientifically compelling and ready to fit into commercial development pipeline.
Out-licensing
Textiles that have been modified by integrating peptide nanostructures show remarkable properties. These include the physical and chemical properties of the fabric, such as strength and fire-resistance, as well as much more advanced properties... More
A new application / Use for Calcitriol - It was demonstrated, in vitro, that calcitriol and some ofits synthetic analogs have the potential to reduce the damage inflicted to normal tissue by accepted anti-cancer therapy. Vitamin D offers protection... More
TA is a broad spectrum antibiotic differing from known antibiotics by virtue of its adhesiveness to
synthetic materials and to biological tissues, whilst retaining its bactericidal activity in the bou
nd form. TA may be topically administered to the... More
Based on many years of careful observation and analysis of mouse behavior, our teams, including zoologists, statisticians, and computer scientists have developed a new hi-res bioassay for preclinical testing and characterization of CNS agents, extracting. More
A novel catalyst technology for the polymerization of a -olefins was developed including several families of pre-catalysts based on early transition metal complexes of amine-phenolate ligands. These pre-catalysts, when activated by various... More
A novel, simple and cost effective assay for monitoring blood levels of rapamycin (sirolimus), and rapamycin analogues was developed. The conceptual basis of the invention is based on the utilization of the Rapamycin specific target, its binding protein.. More
A new homogeneous technique which utilizes fluorescence resonance energy transfer (FRET) to directly detect and distinguish specific DNA sequences without requiring either an amplification step or a separation step has been developed. The detection... More
We propose an alternative to the present drug-coated stents - Peptide(s) coated stents that will coat themselves with human endothelial progenitor cells, will keep arteries open without patients needing the supplement of anti-clotting medications. We... More
Researchers in Tel Aviv University have cloned and characterized Reverse Transcriptase (RT) of PERV-B - a variant that infects human cells and, hence, might infect human recipients of porcine tissues. The recombinant PERV-RT is expressed in bacteria,... More
A series of novel soluble adamantyl-oligoethyleneglycol-fullerene hybrids was prepared via Bingel-Hirsch functionalization of C60 fullerene with various adamantyl-oligoethyleneglycol malonates. As NMDA-targeted antioxidants, these compounds have... More
The Glaucoma Implant is a new shunt that eliminates the complications created by devices currently in use and it may eliminate the need for repeat surgeries. It is small in size, easy to implant and thus causes less discomfort for the patient and results. More
ASSNAC, S-allymercapto-N-acetylcysteine, is a small bi-functional molecule that up-regulates cellular glutathione levels, the major cellular anti-oxidant. ASSNAC dissociates in peripheral tissues, slowly releasing s-allylmercaptan and NAC.... More
Novel cell permeable peptides that fuse a membrane permeation sequence to a functional sequence were developed. These cell-permeable peptides are capable of blocking signal transduction pathways in mast cells, preventing mediator release and the... More
A novel source of surrogate insulin producing beta cells has been developed. Genetic and epigenetic
manipulations are employed to induce differentiation of a number of human progenitor cell types into
mature, functional beta cells for treatment of... More
Conditions have been developed for expansion of functional adult human beta cells.Potential ApplicationsExpansion of functional islet cells from single cadaveric donors for transplantation into multiple recipients for the treatment of Diabetes; and thus. More
A novel source of collagen manifested as fibers derived from certain species of soft corals has been isolated. The New Collagen fibers are strong and flexible compared to commercial collagen. The fibers have a high reversible extensibility... More
Collagomers are bioadhesive micro and macro particles generated by linking a phospholipid to collagen. Collagomers entrap a wide range of molecules and release them slowly over long periods of time.They bind with high affinity to cells providing an... More
An improved algorithm for handling CT scan information which enables the display of all relevant anatomical features in a single image.Potential Applications
CT scans are a basic tool of most medical centers and are in constant use. An improved... More
Using lentiviral delivery of LMX1a, a key player in dopaminergic differentiation, bone marrow–derived MSCs were reprogrammed toward dopaminergic differentiation. In the transduced cells typical midbrain dopaminergic transcripts were... More
Strain maps of blood vessels walls, tissue composition and strain distribution are now possible thro
ugh the use of DQF-MRI (Double Quantum Filtered-MRI). This innovative method is extremely powerful e
asily achieving images of distinct tissue layers,... More
A novel class of bioresorbable composite (core/shell) fiber structures loaded with bioactive agents was developed. These unique polymeric structures are designed to combine good mechanical properties with a desired controlled release profile, in order to. More
An array of nanowire antennas capable of absorbing electromagnetic radiation from the sun and connected to ultrafast rectifying diodes for useful generation of direct current for generating electrical power.Potential Applications
Nanoantennas' ability to. More
Gagomers are novel particles (neither liposomes nor microspheres/nanospheres) composed of hyaluronan shell which is crossed linked via phospholipids. Gagomers could be generated either as micro or nano particles. The research team at Tel Aviv University.. More
We suggest two novel gene tests for psychiatric disorders:
Diagnostics of susceptibility to schizophrenia, based on single nucleotide polymorphism (SNPs) of the golli myelin basic protein (golli-MBP) gene.
A methods for predicting the response to... More
A novel in vivo genetic screen for Hepatitis C virus (HCV) Protease Inhibitors has been developed based on the concerted co-expression of a reporter gene, recombinant Hepatitis C virus (HCV) non-structural 3 (NS3) protease and a potential inhibitor... More
Novel inhibitors of GSK-3 were identified. These inhibitors represent substrate competitors that interact specifically with the GSK-3 substrate binding site. GSK-3 modulates insulin action by controlling the activity of two other proteins in the... More
Guided Regeneration Gel (GRG) is a novel biocompatible, biodegradable hydrogel for peripheral nerve reconstruction and wound healing. ... More
The research teams at Tel Aviv and Bar Ilan Universities have developed novel compounds derived from known histone deacetylase inhibitory (HDACI) molecules linked to acyclovir and its analogs. The new compounds (HDACIvir's) demonstrated potent anticancer. More
A novel fusion protein capable of binding to any internalizing IgG, thus forming a specific and potent immunotoxin, has been developed. The antibody-toxin conjugate is formed through an immuno-complex and may be further stabilized by chemical... More
SVEP1 is a novel cell adhesion protein. Its expression is primarily associated with bone cells but is also expressed by breast carcinoma cells. Anti-SVEP1 antibodies block cell adhesion in in vitro matrix. Prevention of cell adhesion by. More
The aggregation site on human calcitonin has been identified, paving the way for development of specific inhibitors of calcitonin amyloid fibril formation. Such inhibitors will enable development of improved calcitonin therapeutics as well as greatly... More
An improved method for processing audio inputs to hearing impaired, allowing them to better understand speech in a noisy environment.Potential Applications
One of the most common complaints among patients with cochlear hearing loss is difficulty in... More
Dr. Amir Sharon and his team from Tel Aviv University have developed a transformation-based approach through which fungi can be modified to be less sensitive to external conditions and environmental stresses, have increased sustainability in culture... More
Novel inhibitors directed against a newly identified sequence, aimed to prevent amyloid plaque formation and beta cell death are currently being developed. These inhibitors present a novel approach to the treatment of Type II Diabetes and prevention of. More
A novel anti cancer treatment for the destruction of both local primary tumors and remote metastatic cells has been developed. The treatment is based on low voltage pulsed electric fields employed in combination with chemotherapeutic agents... More
An antibiotic of the Macrolid family was demonstrated as a new treatment for colorectal cancer and other genetic human diseases that arise from pre-mature stop codons in important coding sequences.Potential ApplicationsPotential applications include... More
Prof. Naor’s team has recently discovered that two Mitogen-Activated Protein Kinases (MAPKs) play a role in human sperm functions. The team discovered that human sperm progressive and hyperactivated motility is maintained by the ratio of these... More
Brain macromolecules can now be detected and identified according to contrasting macromolecular char
acteristics of the tissues, using this new MRI sequence. The dynamics and rigidity of a host of macr
omolecules can be identified, including proteins and. More
Gaucher disease (GD) is an inherited inborn of metabolism, resulting from mutations in the glucocerebrosidase gene, which lead to accumulation of the substrate glucosylceramide in lysosomes. Prof. Mia Horowitz and her research team have discovered that... More
A battery of novel natural marine compounds were isolated and characterized as potentially anti-proliferative and pro-apoptotic. The compounds that were isolated from the Madagascar marine sponge Fascaplysinopsis sp are attractive candidates for further.. More
A new serum marker specific for liver disease has been discovered. The marker is the soluble form of the human asialoglycoprotein receptor (ASGPR). An ELISA assay was developed with specific monoclonal antibodies that confirmed the correlation between... More
We have identified ALS-specific patterns of gene expression in MSCs and peripheral WBCs. These biomarkers are strong candidates for ALS diagnosis since they can be easy and rapidly detected in peripheral blood samples using specific and reliable RT-PCR... More
Two non-toxic short peptides were conjugated to form a novel drug candidate. One of the peptides is a polymyxin-B or polymyxin-E analog (PMBN or PMEN, respectively) while the other is an immune cell chemotactic peptide (fMLF). The resultant new drug... More
The researchers at Tel Aviv University and Perrigo Pharmaceuticals have developed a platform technology (the Rotem Platform) enabling the development of potent anti cancer drugs based on the chemical modifications of known psychotropics. The leading... More
Alasan is a novel bioemulsifier produced by the microorganism Acinetobacter radioresistens KA53. It is a high molecular weight complex composed of an anionic polysaccharide containing a significant % of covalently bound alanine and four... More
Novel single chain and single domain antibodies and peptide aptamers which inhibit NS3 protease, have been isolated.Potential ApplicationsTreating HCV infection Treating or preventing the symptoms of hepatitis Preventing liver damage Preventing... More
A series of novel markers: (1) chromatin remodeling protein factor termed (CHD9/CReMM), (2) A cell adhesion protein termed (SVEP1), (3) A kinesin protein termed (MS-KIF18A), (4) RNA processing factor (SRRF/hNRNP-L) have been developed as novel markers... More
A novel deposition method based on the vacuum arc has been developed to deposit thin films and coating. The method utilizes a homogenous plasma jet which is free of film-degrading macroparticles.Potential Applications
A major cost element in the... More
Gagomers are novel particles (neither liposomes nor microspheres/nanospheres) composed of hyaluronan shell which is crossed linked to phospholipids and can be generated either as micro or nano particles. The research team at Tel Aviv University has... More
Novel peptides were identified that bind endothelial cells and induce angiogenesis. The peptides were demonstrated to induce proliferation, migration and vascularization of endothelial cells under hypoxic conditions and completely restored blood... More
New Chemical Entities (NCE's) psychotropic agents have been developed, possessing anti-dopaminergic activity, along with positive modulatory glutamate NMDA receptor activity. These agents are aimed at the treatment of schizophrenia and bipolar disorder... More
MicroRNAs (miRNAs) are an abundant class of short endogenous noncoding RNAs that act as post-transcriptional regulators of gene expression by base-pairing with their target mRNAs. ... More
The invention provides for an increase in the expression of heterogeneous membrane proteins as well as crystallization ability. This is achieved by addition of hydrophilic alpha-helical segments to the desired membrane protein, via a cloning procedure.... More
A very accurate method utilizing a combination of non-intrusive installed vibration detectors and microphones to detect the fall of humans in the domicile.Potential Applications
The device is useful for individuals living alone, and for seniors in... More
The invention consists of introducing a pH influenced polychromatic ultra-violet (UV) photolysis process for disinfection of water contaminated by several organic components (alone or in a mixture of contaminants), where the pH to enhance contaminant... More
A nano-sized pattern which is extremely difficult to duplicate is printed on a product tag. Conventional scanners can be used to read and verify the pattern. A single mold should be able to print millions of patterns, making the system robust,... More
Automatic, non-invasive and immediate diagnosis of ovarian malignancy with an accuracy rate of over 90% is made possible through this innovative Real-time Diagnostic ultrasound package. The package includes two components, which together increase... More
A breakthrough Self Assembled Peptide Hydrogel (SAPH) has been developed by Professor Ehud Gazit and his team at Tel Aviv University. SAPH is a safe, self assembled, biocompatible, remarkably strong hydrogel with modulated stability that is suitable for.. More
Aromatic dipeptides have been demonstrated to self-assemble into discrete nanotubes that are, upon design, either sensitive or resistant to enzymatic degradation. Such nanotubes are homogeneous, with micron-scale persistence length and can serve as molds. More
Serotonin-selective reuptake inhibitors (SSRIs) were chemically modified to produce novel quaternary nitrogen derivatives having a peripheral-restricted serotonin reuptake inhibitory activity. The lead compound GR-101 was demonstrated as a novel... More
We suggest a novel mode of treatment by inhibition of mortalin or mortalin synthesis as an adjuvant to antibody-based immunotherapy.Novel siRNA was designed as blocker of Mortalin expression. The anti-mortalin siRNA binds specifically to mortalin mRNA... More
Dendrimers were synthesized, whereby a single specific cleavage event releases all the functional groups at the tips of the dendrimer, via spontaneous fragmentation of the dendrimer to its building blocks. These dendrimers, with the capacity to self... More
Reduced signal loss and the achievement of optimal contrast for imaging tendons and ligaments are ma
de possible through the innovation of Slice-Selective Double Quantum Filter MRI (DQF-MRI). This new
DQF-MRI is performed on a time scale shorter than any. More
The invention is a new and objective device for detecting diabetic neuropathy in the feet which are by far the most common points for loss of nerve activity in diabetic patients. It consists of an array of computer-controlled stimulators in a floor mat... More
Targeted drug-carrying filamentous bacteriophages have been developed as a novel therapeutic approach for the treatment of infectious diseases and cancer. The phages are genetically-modified to display an antibody or a targeting peptide as a targeting... More
Novel particulate drug delivery technology comprises of lipidated Glycosaminoglycan, that form micro or nano particles in a controlled manner. The particles (neither a liposome nor a microsphere/nanosphere) can encapsulate DNA, proteins and small... More
A new strategy for cancer and bone metastases therapy was developed using combined targeted polymeric drug delivery system with angiogenesis inhibitors. The novel compounds are composed of three elements:
Water soluble synthetic copolymer (HPMA) as... More
A new strategy for cancer treatment using PARP inhibitors is been developed. The active compounds include the molecule PJ-34 and additional phenanthridine derived PARP inhibitors. ... More
The 3-D Thin-film Microbattery is a, lithium or lithium-ion battery conformally formed on all exposed surfaces of a perforated substrate. The extended area provides an increase of 1-2 orders of magnitude in specific energy (per volume and weight) and... More
The innovation involves a novel application of Phenyl Boronic Acid (PBA) and its derivatives as a new fungicide for the treatment of onychomycosis. Prof. Amihay Freeman, has shown that specific PBA derivatives have fungicidal activity against... More
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Company figures
Formed: 1973
Number of employees: 28
Number of employees: 28
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