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Pharmalicensing
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Companies

Columbia Technology Ventures

Columbia Technology Ventures
Columbia Technology Ventures manages Columbia University’s intellectual property portfolio and serves as the University’s gateway for companies seeking novel technology solutions.

The company in detail

Profile

Our mission at Columbia Technology Ventures is to:

•     Facilitate the translation of academic research into practical applications, for the benefit of society on a local, national and global basis

•     Support research, education and teaching at Columbia by generating funding for the University and facilitating partnerships with industry where appropriate

•     Educate and serve as a resource for the Columbia community on matters relating to entrepreneurship, intellectual property, and technology commercialization

Columbia Technology Ventures is widely considered one of the most experienced and successful technology transfer offices in the world.  On average, we receive and triage more than 300 new invention disclosures from faculty, students and staff, execute 50-60 license deals, and help launch 10-12 start-ups each year.  Columbia’s inventions are behind several well-known life-saving or life-improving biopharmaceutical products, including Remicade; ReoPro; Tysabri; Erbitux; Simponi; Zolinza; Synagis; Xalatan / Xalcom; Epogen; Avonex; and Herceptin.

Our success is due to an exceptional base of world-class scientists working in diverse and dynamic areas of science and engineering.  Since the founding of our office in 1982, Columbia inventions have generated significant economic returns and have contributed to advances in a wide range of fields and markets, resulting in hundreds of products and services that touch the daily lives of people all over the world.

Columbia Technology Ventures employs 49 full-time, interdisciplinary staff, including 11 PhDs, 9 JDs, and 8 MBAs, at two offices, on Columbia’s Morningside and Medical Center campuses.  

Partnering strategy/interests

Our licensing officers, many of whom have significant industry experience, strive to achieve practical solutions that form the basis of a common understanding on which solid relationships can be built. We value partners who also take a flexible approach to deal-making and who appreciate our need to strike a balance between upholding core academic values – seeking knowledge, freedom of publication, and open discourse – and preserving competitive advantage for our partners in the marketplace.

By the nature of academic endeavors, our inventions often require significant additional development in order to succeed as commercially viable products and/or services.  We understand the importance of industry collaborators throughout this process and seek partners who have demonstrated ability and experience in bringing early-stage inventions and technologies to market.

Out-licensing

Lead Inventor: Andrew R. Marks, M.D. Problem or Unmet Need: While progress has been made in the treatment of various cardiovascular diseases, the increasing incidence of heart failure (a syndrome resulting from long-term cardiac disease) in combination... More
Name of the inventor: Howard L. Kaufman An anti-cancer therapy for carcinoembryonic antigen (CEA) expressing solid tumors and a general method for developing bacterial vector towards tumors with known biomarkers. The inventors engineered a recombinant... More
Lead Inventor: Denong Wang Problem or Unmet Need: A protein microarray is a coated glass slide onto which different proteins have been affixed in an ordered fashion. Fluorescence patterns change upon antigen/antibody binding which can be detected via... More
The technology is an affinity based glucose sensor, which uses a glucose binding polymer incorporated into a Micro Electro-Mechanical System (MEMS) to dynamically monitor glucose concentrations in solution. More
Name of the inventor: Reba Goodman A non-invasive method for gene regulation during gene therapy is described. The method involves the introduction of electromagnetic field response elements into a gene promoter. The elements are then stimulated by... More
Lead Inventor: Andrey Rzhetsky STV Reference: IR 1750 and IR 1902 Problem or Unmet Need: One of the major practical goals of genetics is to find the genetic origin of diseases and to understand how genetic mutations may alter particular physiological... More
Lead Inventor: Andrey Rzhetsky STV Reference: IR 1750 and IR 1902 Problem or Unmet Need: One of the major practical goals of genetics is to find the genetic origin of diseases and to understand how genetic mutations may alter particular physiological... More
Name of the inventor: Jonathan M. Barasch A method of inducing the kidney epithelium formation is described. Methods of treating a subject with kidney failure, preserving a kidney for transplantation purposes are also proposed. The method involves... More
Name of the inventor: Cy Stein Topical administration of a modified oligonucleotide for the treatment of glaucoma is discussed. The oligonucleotide may be substituted or modified in its phosphate, sugar or base so as to decrease the intraocular pressure.. More
Lead Inventor: Dr. B. Jack Longley Problem or Unmet Need: The skin is responsible for protecting the body from pathogens, temperature regulation, hair growth and vitamin production. Melanin, a brown pigment, is produced by melanocytes and taken up by... More
Lead Inventors: Simon Maybaum, Jie Wang STV Reference: IR# 1675 & IR# 1509 Problem or Unmet Need: Heart failure, also called Congestive Heart Failure (CHF) is a progressive pathophysiologic condition where cardiac function is impaired to a degree that... More
Lead Inventors: Simon Maybaum, Jie Wang STV Reference: IR# 1675 & IR# 1509 Problem or Unmet Need: Heart failure, also called Congestive Heart Failure (CHF) is a progressive pathophysiologic condition where cardiac function is impaired to a degree that... More
Lead Inventors: Wei Gu Problem or Unmet Need: Aging and aging-related diseases are fast becoming a widespread concern in most developed countries, contributing to increased pressure on healthcare providers and other social services. Extending the life... More
Name of the inventor: David Mark Stern. Calreticulin is a polypeptide that was found to bind Factor IX/IXa and prothrombin. This invention covers a means of using Calreticulin for blocking or preventing thrombosis in a subject without affecting normal... More
Lead Inventors: Saul J. Silverstein, Christos Kyratsous. Problem or Unmet Need: Combination antiviral therapies are considered to be superior to monotherapies because they often have more anti-viral benefits and less toxicity. Novel anti-viral mechanisms. More
Lead Inventors: Andreas Hugo Kottmann, Ph.D. Problem or Unmet Need: Parkinson's disease (PD) affects about 1% of the population over the age 60. The biggest challenge of current PD treatments is that they cannot slow the onset of PD or cure the disease... More
Name of the inventor: Eric Kandel Methods for determining whether an agent facilitates the conversion of a cytoplasmic polyadenylation element binding (CPEB) protein from its non-prion form to its prion form are described. Methods for determining the... More
Name of the inventor: Scott Banta Problem or Unmet Need: Peptides are an intriguing mode of therapy due to their potential potency, high specificity, and low toxicity. Endogenous protease degradation is a major barrier to using short peptides as... More
Name of the inventor: Nan Wang Isolated ABCA1 protein having a mutation within its PEST domain, related nucleic acids, vectors, host cells, pharmaceutical compositions and articles of manufacture are described. A method for increasing the formation of... More
Name of the inventor: Bernard Erlanger A monoclonal antibody that specifically recognizes N-methyl leucine residues of cyclosporine and methods for the treatment of HIV infection and AIDS employing this antibody are described. The method for treating... More
Lead Inventors: Hua Gu, Ph.D. Problem or Unmet Need: CD8+ T-cells become activated in the immune system in response to tumor cells. Once activated, CD8+ T-cells are recognized as cytotoxic, or killer T-cells, which are capable of inducing the death of... More
Lead Inventors: Joseph A. Gogos, Maria Karayiorgou Problem or Unmet Need: Microdeletions in chromosome region 22q11 are associated, with relatively high frequency, with severe mental illness. Whereas a person in the general population has a risk of about. More
Lead Inventor: Richard Mayeux, MD Problem or Unmet Need: The ability to diagnose Alzheimer's disease (AD) is complicated by the multiplicity of symptoms and lack of understanding of the underlying causes. The most indicative symptom of Alzheimer's, onset. More
Name of the inventor: Judah Z. Weinberger The apparatus is a balloon catheter having a central balloon and two edge balloons. The central balloon may be separately inflated temporally and with different radioactive fluid than the edge balloons. Other... More
Name of the inventor: Kevan Herold Methods for treating autoimmunity and for reestablishing tolerance are described. The method for restoring/inducing tolerance and inhibiting/preventing an immune response against a self-antigen comprises administering... More
Name of the inventor: Linda S. Einbond Related Technologies: IR# 2425 & IR# 2427 A composition for use in treating/preventing neoplasia using an extract from black cohosh. A method for treating or preventing neoplasia in a subject, involves the... More
Name of the inventor: Sherie L. Morrison A method of altering the affinity of an antibody for an antigen by modifying the carbohydrate content of the antibody. A carbohydrate recognition site may be introduced into the variable region of the antibody... More
Name of the inventor: Robert E. Canfield M.D. A monoclonal antibody which specifically binds to hLH. beta. cf (helix-turn-helix beta. core fragment) without cross-reacting with hLH, hLH.beta. or hCG .beta. cf (human chorionic gonadotropin beta core... More
Name of the inventor: Shanta M. Modak An antimicrobial composition comprising optimal percentage compositions of chlorhexidine free base, a chlorhexidine salt, polyhexamethylene biguanide, alexidine, a quaternary ammonium compound and a chlorinated... More
Name of the inventor: Shanta M. Modak Medical articles impregnated with antimicrobial compositions containing synergistic combinations of octoxyglycerin and other anti-infective compounds such as salicylic acid and sesquiterpenoids are described. The... More
Name of the inventor: Judah Z. Weinberger An apparatus and associated method for treating a disease process in a luminal structure of a subject is described. A complex of a radionuclide and a chelating agent in an amount effective to inhibit the disease.. More
Name of the inventor: Judah Z. Weinberger A radiation therapy apparatus and method for applying radiation to a patient in synchronism with one of several states of a cardiac cycle and one of several states of a respiratory cycle of the patient are... More
Name of the inventor: Judah Z. Weinberger An apparatus for reducing restenosis after arterial intervention in the patient's artery. The apparatus is guided by a guide wire within a patient's artery for reducing restenosis after arterial intervention in... More
Name of the inventor: Judah Z. Weinberger An apparatus for treating a disease process in the vicinity of a luminal structure using a balloon catheter including radioactive material is described. The balloon catheter has a shaft and an inflatable balloon.. More
Lead Inventor: Judah Z. Weinberger, MD Problem or Unmet Need: The three primary modes of access to the blood in hemodialysis include an intravenous catheter, an arteriovenous fistula, or an arteriovenous graft. Using the catheter access mode almost... More
Name of the inventor: Marc Bessler MD A method and device for implanting an artificial heart valve using minimally invasive techniques especially endovascular techniques is described. The artificial heart valve comprises a self-expanding, cylindrical... More
Name of the inventor: Stephen L. Sturley Isolated nucleic acid molecules encoding human and yeast ACAT-Related Enzyme 2 required for viability protein (ARV1p) and the purified forms of the said proteins are described. Method for identifying a chemical... More
Lead Inventor: George Hripcsak Problem or Unmet Need: Health care providers increasingly rely on automated computer programs for monitoring patient characteristics (e.g. vital signs), medical events (e.g. admissions, discharges, operative procedures, and. More
Lead Inventors: Franklin D. Constantini Ph.D. and Zeng Li Problem or Unmet Need: The Wnt signaling pathway is a complex network of proteins that plays a role in cancer, embryogenesis, adult neurogenesis and axon guidance. Given its relevance, the Wnt... More
Name of the inventor: Virginia Cornish A transgenic bacterial cell adapted for use in identifying a molecule that binds to a known target in a bacterial cell from a pool of candidate molecules, and a method for identifying an unknown target receptor to... More
Name of the inventor: I. Bernard Weinstein Biologically pure cultures of microorganisms designated SH2A and SH2B or their mutant forms are disclosed. A method of using SH2A/SH2B or their mutant forms to degrade an organic material and for growing... More
Name of the inventor: Beth C. Levine An isolated nucleic acid which encodes a wild-type human beclin and a mutant human beclin is described. A method of producing a wild-type human beclin using a host-vector system and method of recovery and purification. More
Name of the primary inventor: Jeremy Mao. Invention: Composition and methods for in vivo synthesis of fibrous tissue Unmet Need: Current technologies for repair of fibrous tissues, e.g. anterior cruciate ligament, include use of graft materials from... More
Name of the primary inventor: Jeremy Mao. Invention: Composition and methods for replacement of synovial joints. Unmet Need: Synovial joints are susceptible to osteoarthritis (OA), rheumatoid arthritis (RA), trauma, and congenital anomalies. An estimated. More
Lead Inventor: Helen Lu Problem or Unmet Need: Chronic degeneration and tears of the rotator cuff are extremely challenging to treat. Clinical failure rates up to 38% have been reported after repairing rotator cuff injuries, and use of implants or grafts. More
Lead Inventor: Linda S. Einbond, Ph.D. Related Technologies: IR# 1390 & IR# 2427 Problem or Unmet Need: Many anti-cancer drugs currently in use are toxic compounds that cause significant side effects. These agents are often not particularly selective for. More
Lead Inventor: Linda S. Einbond, Ph.D. Related Technologies: IR# 1390 & IR# 2425 Problem or Unmet Need: Many anti-cancer drugs currently in use are toxic compounds that cause significant side effects. These agents are often not particularly selective for. More
Name of the inventor: Eric Kandel Title of the invention: Brain and heart cyclic nucleotide gated ion channel compounds and uses thereof An isolated nucleic acid encoding a BCNG protein, BCNG-related protein or their portions is described. Methods for... More
Lead Inventors: Robert L. Fine; Paul Brandt-Rauf; Yueha Mao Problem or Unmet Need: More than 50% of human malignancies, including breast cancers, are associated with missense mutations or deletions of p53, a sequence-specific transcriptional factor... More
Lead Inventors: Michael R. Rosen, Richard B. Robinson, Peter R. Brink, Ira S. Cohen Problem or Unmet Need ~ Myocardial infarction affects more than 500,000 patients in the United States each year. Conventional therapy was limited by insufficient... More
Name of the inventor: David J. Pinsky M.D. A method to treat/prevent thrombotic or ischemic disorders in a subject through the administration of an agent that inhibits ADP-mediated platelet aggregation by increasing ADP catabolism is described. A method.. More
Name of the Inventor: Arthur Bank The genes of the Moloney murine leukemia virus have been separated onto two plasmids - one containing the gag and pol genes, and the other containing either an amphotropic or an ecotropic env gene. The plasmids were... More
Name of the inventor: Tilla S. Worgall A method for decreasing the amount of mSREBP in a cell characterized by an elevated level of sterol regulatory element binding-proteins (mSREBP), related methods and articles of manufacture are described. The method. More
Name of the inventor: Seymour Lieberman Heteropolymers Composed of Two or More Different Monosaccharide Units; The Preparation Thereof and Their Uses as Clinical and Therapeutic Agents. Problem or Unmet Need: Synthetic forms of polysaccharides are unlike. More
Name of the inventor: Sherie L. Morrison PhD A modified chimeric monoclonal antibody comprising two molecules of each of two different polypeptides. The shorter polypeptides function as the light chains of the antibody and the longer polypeptides... More
Name of the inventor: Mary Jane Potash Ph.D. The invention provides a chimeric HIV construct that infects murine cells and thereby generates a small animal (rodent) model of HIV-1 infection and AIDS. This invention presents the first rodent model of... More
Name of the inventor: Thomas M. Jessell Ph.D. An isolated vertebrate nucleic acid molecule encoding F-spondin. A nucleic acid probe capable of specifically hybridizing with a sequence included within the nucleic acid sequence encoding an F-spondin is... More
Name of the inventor: Jingyue Ju PhD Combinatorial fluorescence energy transfer tags and their use in multi-component analyses, including multiplex biological analyses are described. The method comprises of multiple fluorophores, each of which is bound... More
Lead Inventors: Martin Chalfie, PhD Problem or Unmet Need: Fluorescent proteins, first developed as biological markers by Dr. Chalfie, have become a key reagent in the molecular biology toolbox. Green Fluorescent Protein (GFP) and its derivatives are... More
Name of the inventor: Paul Fisher A method for inhibiting proliferation and inducing cell death in a population of cancer cells by increasing the amount of the differentiation associated protein, mda-7 and decreasing RAS activity within the cell... More
Name of the inventor: Paul Fisher Compositions and methods for the detection and therapy of breast cancer are described. The isolated polypeptide comprises an immunologically active portion of a tumor-associated protein or a variant. A vaccine comprises.. More
Name of the inventor: Paul Fisher Compositions and methods for the detection and therapy of prostate cancer are described. The isolated polypeptide comprises an immunologically active portion of a tumor-associated protein or a variant. A vaccine... More
Name of the inventor: Lucien Del Priore Compositions and methods for reversing age-related changes in extracellular matrix proteins, particularly the collagen framework of basement membranes of various organs are described. Age-related changes in... More
Name of the inventor: Hina Chaudhry Methods for promoting generation of heart tissue and for treating and preventing heart tissue degeneration are described. The method for treating or preventing heart tissue degeneration in a subject involves a... More
Lead Inventor: Andrew R. Marks Problem or Unmet Need: Cardiac hypertrophy is a condition of the heart characterized by an increase in size of the cardiac muscle. Cardiac hypertrophy is a significant risk factor for both mortality and morbidity in heart... More
Lead Inventor: Andrew R. Marks Problem or Unmet Need: Ryanodine receptors (RyRs) are channels that open and close to regulate the release of Ca2+ from intracellular stores into the cytoplasm of the cell. RyRs have been shown to be involved in learning... More
Name of the inventor: Wayne A. Hendrickson HIV-1infection in subjects is prevented by using a compound that prevents the interaction between HIV-1gp120 and CD4 receptors on the surface of cells. The compound binds to the central cavity between HIV-1... More
Name of the inventor: Carol M. Troy MD, PhD A method of inhibiting cell death and for alleviating symptoms of a neurodegenerative disorder in a subject is described. The method involves inhibition of enzyme activity on a substrate in a cell by contacting. More
This technology consists of a customized computer-based system for rapid and real-time hemodynamic analysis during BiVP optimization. More
Lead Inventor: Angela M. Christiano, Ph.D. Problem or Unmet Need The lack of treatments available for people with absent, weak, or slow growing nails (because of inherited abnormalities or infection) is partly due to poor understanding of the molecular... More
Lead Inventor: Lawrence Shapiro Problem or Unmet Need: The drug development of energy balance disorders, such as obesity and type-2 diabetes, is limited by lack of detailed understanding of metabolic control. A key target in this area is the adenosine... More
Lead Inventors: Wei Gu Problem or Unmet Need: Aging and aging-related diseases are fast becoming a widespread concern in most developed countries, contributing to increased pressure on healthcare providers and other social services. Extending the life... More
Name of the inventor: Peter Brink A method for delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell is described. The method of delivering RNA/oligonucleotide into a target cell comprises introducing RNA or a... More
Name of the inventors: Helen Lu & Gunnar Hasselgren The Challenge/ Problem/ Unmet Need The health of a human tooth depends on the integrity of the dental hard tissues and the support of living soft tissues. The enamel is the outer hard layer of the tooth. More
Name of the inventor: Paul Maddon A therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein comprising a soluble T4 polypeptide. A pharmaceutical composition comprising of an effective amount of. More
Name of the inventor: Mahmoud El-Tamer, M.D. Method for the identification of sentinel lymph node particularly those with cancer using a detectably labeled porphyrin compound is described. A radio-labeled gamma emitting detectable labeled porphyrin... More
Name of the inventor: Paul Fisher A method of detecting cancer metastatic cells in a subject is described. The method involves obtaining a nucleic acid sample from the subject's blood, amplifying nucleic acid encoding the product of prostate carcinoma... More
Name of principal inventor: Konstantina Alexandropoulos Problem or Unmet Need T cells are immune cells that circulate in the blood and play important roles in autoimmune diseases, infectious diseases, and some cancers. One novel method of researching how. More
Patients with a wide range of acute neurological diseases/injuries frequently undergo bedside insertion of external ventricular drains (EVDs) for emergent management of elevated intracranial pressure and drainage of cerebrospinal fluid. More
Name of the inventor: John Pile-Spellman MD Endovascular intervention methods that help protect against distal embolisms. A temporary capillary block is created to wedge blood flow in an organ. Once the blood flow is blocked, an endovascular intervention. More
Lead Inventor: Gerard M. Turino Problem or Unmet Need: One of the key measurements in Chronic Obstructive Pulmonary Disease (COPD) diagnosis is lung elastin degradation which occurs with the development of pulmonary emphysema. Current measurements of... More
Name of the inventor: Ira S. Cohen Method for treating a subject afflicted with a cardiac disorder and related articles of manufacture are described. The method comprises inducing differentiation of a progenitor cell, in-vitro, to a cardiogenic cell and.. More
Name of the inventor: Fei Huang Compositions and methods for inhibiting cell growth, inducing terminal differentiation and cancer therapy are described. The isolated polypeptide comprises a portion of a differentiation-associated protein/a variant where.. More
This technology consists of methods and systems for a digital signal processor based detection system for optical tomography. More
Lead Inventor: Richard Ambron Problem or Unmet Need: Neuropathic pain is a complex chronic pain state that often follows tissue injury where nerves fibers are damaged. Neuropathic pain often responds poorly to standard pain treatments and can worsen over. More
Lead Inventors: Andrea Califano, Ph.D. and Ricardo Dalla-Favera, M.D. Problem or Unmet Need: The discovery of miRNAs, a class of short-RNA that impairs translation or induces mRNA degradation, has added a new dimension to the mechanisms that regulate... More
Name of principal inventor: Brent Stockwell Ph.D. Problem or Unmet Need: Many anti-cancer drugs currently in use are toxic compounds that cause significant side effects. These agents are often not particularly selective for tumor cells and can cause... More
Lead Inventors: Donald W. Landry, M.D., Ph.D. and Milan N. Stojanovic, Ph.D. Problem or Unmet Need: The growing use of small molecule compounds in daily basic, clinical, and diagnostic research demands a simple, quick, and affordable assay to measure... More
Name of the inventor: Stephen L. Sturley An isolated nucleic acid which encodes a human wild-type acylcoenzyme A/cholesterol acyltransferase II or III in yeast is described. A method for identifying a chemical compound which is capable of inhibiting... More
Name of the inventor: I. Bernard Weinstein A DNA of a bacterium or protozoan is brought into contact with a DNA oligomer complementary to a DNA sequence under an appropriate condition of polymerase chain reaction (PCR). The DNA sequence encodes a... More
Lead Inventors: Synaptic Pharmaceutical Corporation STV Reference: 1852-1856 Problem or Unmet Need: GABA is the major inhibitory neurotransmitter in the CNS. Maintenance of proper GABA levels prevents epileptic seizures. Inhibitors of GABA, taurine, and.. More
Name of the inventor: Sherie L. Morrison PhD An antibody having a binding site region and a domain-modified constant region. The domain-modified constant region is a substitution, duplication, or deletion of substantially all of the amino acids of... More
Name of the inventor: Leonidas Stefanis and Lloyd Greene The invention discloses a PC12 cell line stably expressing Human A53Talpha-synuclein, and methods of using the same. The cells of the cell line are characterized by proteasomal dysfunction,... More
Name of the inventor: Thomas M. Jessell Ph.D. An isolated vertebrate nucleic acid molecule which encodes dorsalin-1 and a nucleic acid probe capable of specifically hybridizing with a sequence included within this nucleic acid sequence. A host vector... More
Lead Inventor: Regina Santella Problem or Unmet Need: Hepatocellular carcinoma (HCC) is one of the most common and serious human cancers; nearly 500,000 patients are diagnosed annually. A lack of effective therapeutics and advanced stage diagnosis cause.. More
Name of the inventor: Katherine Lu Molnar-Kimber Novel Rapamycin-FKBP12 binding proteins of mammalian origin, methods for isolating these proteins and therapeutic uses related to the proteins are described. The method for the synthesis of an isolated... More
Name of the inventor: R. Theodore Smith A method of leveling an image with non-uniform background and also computer software for leveling an image with non-uniform background, are described. The basic data of an image with non-uniform background is... More
Name of the inventor: Stephen P. Goff A plasmid gene is expressed to produce a polypeptide having HTLV-III (Human T-cell lymphotropic virus III) reverse transcriptase activity when the plasmid is introduced into a suitable host cell and grown under... More
Name of the inventor: Joyce Lustbader A nucleic acid molecule encoding a soluble polypeptide including the extracellular domain region of gonadotropin receptors and a thioredoxin is disclosed. The soluble polypeptide binds to gonadotropin and may be... More
Lead Inventor: W. Ian Lipkin, M.D. Problem or Unmet Need: In both autoimmune and inflammatory diseases, the condition arises through aberrant reactions of the human adaptive or innate immune systems. Immunosuppressive drugs, such as corticosteroids and... More
Name of the inventor: Domenico Accili Problem or Unmet Need: Type II diabetes is a very complex disease involving many tissues and several key protein components, two of which are insulin receptor and the transcription factor FoxO1. Recently, FoxO1 was... More
Name of the inventor: Stuart Firestein Methods and materials for expressing and assaying functional neuronal receptors in neuronal cells and for detecting particular odorant ligand specificity for particular odorant receptors and their uses. The method... More
Lead Inventor: Julide Tok Celebi Problem or Unmet Need: Melanoma is the fifth most common cancer in the US. If diagnosed in the early stages, melanoma can be treated with surgery; however metastatic disease has a poor prognosis with a median survival of.. More
Name of the inventor: Andrey Rzhetsky Methods for identifying novel genes and for performing simulation and hypothesis testing to identify a novel gene of interest are described. The method comprises generating one/more specialized databases containing... More
Name of the inventor: Rene Hen Generation of Mice Lacking the 5HT5-A Receptor From Increased Exploratory Activity and Altered Response to LSD in Mice Lacking the 5-HT(5A) Receptor, Neuron, Vol. 22, 581-591, March, 1999. R. Grailhe, C. Waeber, S. Dulawa,.. More
Name of the inventor: Thomas M. Jessell Ph.D. A method of converting a stem cell into a ventral neuron is described. Methods for diagnosing and treating neuronal degeneration in the subject are also described. A nucleic acid which expresses homeodomain... More
Lead Inventors: Oleg Evgrafov, Vincent Timmerman and Alexander Polyakov Details of the Invention: This invention provides five different mutations in heat shock protein B1 (HSPB1; also known as heat shock protein 27). These gene mutations were identified. More
Name of the inventor: Jason Chen Genetically engineered cell lines and recombinant vectors for the propagation of Varicella zoster virus (VZV) are described. Vaccines and a method of screening for an agent to treat VZV infection are also disclosed. A... More
Lead Inventor: Koji Nakanishi Problem or Unmet Need: Ginkgo biloba is a frequently used herbal remedy for increasing cognitive function in the elderly and Alzheimer's patients, treating vascular and neurodegenerative dementia, and improving circulation... More
Lead Inventor: Regina Landesberg D.M.D. and Helen Lu, Ph.D. STV Reference: IR 1421 and 1678 Problem or Unmet Need: Currently, one in every eight Americans is over the age of 65. For this reason, more effective and less invasive therapies targeted to the.. More
Name of the principal inventor: Eric Kandel This invention provides a method for treating a subject afflicted with a fear-related disorder comprising administering to the subject a therapeutically effective amount of a gastrin-releasing peptide receptor.. More
Name of the inventor: Michael R. Treat MD Device and method for propelling objects using periodic or harmonic vibrations is described. A source of vibrational energy is applied to the substantially flat surface of a flexible substrate capable of... More
Name of the inventor: Howard Worman A method of treating or preventing hepatitis C virus infection in a subject by administering an effective amount of an agent to the subject is proposed. The agent is capable of inhibiting the attachment of hepatitis C.. More
Name of the inventor: Donald William Landry MD, Ph.D. A method for inhibiting the onset of malnutrition in a dialysis patient is described. Methods and kits for performing dialysis that treats/inhibits the onset of malnutrition in the dialysis patient... More
Name of the inventor: Thomas M. Jessell Ph.D. Methods for generating genetically engineered neurons for treating subjects having a motor neuron injury or a motor neuron disease are described. The method involves implanting genetically engineered neural... More
Name of the inventor: Nicole Suciu-Foca The invention includes methods for detecting and treating allograft transplant rejection, as well as for modulating the T cell immune response. A specialized subset of T suppressor (Ts) cells with the phenotype... More
Name of the inventor: Nicole Suciu-Foca The invention includes methods for detecting and treating allograft transplant rejection, as well as for modulating the T cell immune response. A specialized subset of T suppressor (Ts) cells with the phenotype... More
Name of the inventor: Nicole Suciu-Foca Method for inhibiting the onset of or treating the rejection of an antigenic substance is described. Further, inhibiting the onset of or treating an autoimmune disease in a subject is also disclosed. The method... More
Name of the lead innovator: X. Edward Guo Micro computed X-ray tomography (Micro-CT) and micro magnetic resonance imaging (Micro-MRI) are significant advances for visualization, measurement, and reconstruction of microstructure in a number of... More
Lead Inventor: Kevan Herold, MD Problem or Unmet Need: A variety of diseases, including diabetes, are the result of overactive immune cells attacking healthy tissue. Small molecule immunosuppressive agents act broadly against the immune system and lead... More
Name of the inventor: Bernard F. Erlanger Ph.D. An antibody which specifically binds to the product of a reaction between a labeling substance/a substrate and an associated immunoassay is described. The antibody may be monoclonal/polyclonal and the... More
Name of the inventor: Paul Fisher A method of generating a reverse tetracycline controlled transactivator expression system for inducible tetracycline regulated gene expression is described. A vector construct comprises of Protein Translation Peptide... More
This "stress shielding" leads to osteolysis, visible as holes in the bone under radiographic examination. More
Name of the primary inventor: Jeremy Mao. Invention: Composition and methods of inducing in situ, post-implant differentiation of stem cells or precursor cells into target cell types. Unmet Need: Attempts to engineer cartilage using stem cells or... More
Name of the inventor: Virginia W. Cornish Description #1: An in vivo screening method for proteins and drugs using chemical inducers of protein dimerization is disclosed. A method for determining if a protein interacts with a ligand in vivo is described.. More
Name of the inventor: Virginia W. Cornish Description #1: An in vivo screening method for proteins and drugs using chemical inducers of protein dimerization is disclosed. A method for determining if a protein interacts with a ligand in vivo is described.. More
Name of the inventor: Virginia W. Cornish Description #1: An in vivo screening method for proteins and drugs using chemical inducers of protein dimerization is disclosed. A method for determining if a protein interacts with a ligand in vivo is described.. More
Name of the inventor: Virginia W. Cornish Description #1: An in vivo screening method for proteins and drugs using chemical inducers of protein dimerization is disclosed. A method for determining if a protein interacts with a ligand in vivo is described.. More
Lead Inventor: Franklin Lowy Problem or Unmet Need: A serious complication in the use of implanted medical devices, such as intravascular catheters and ventricular assist devices (VADs), is the high rate of device-related infections. Staphylococcus... More
Name of the inventor: Dezider Grunberger A method of inhibiting the formation of a cataract in an eye and a method of inhibiting the progression of cataract formation in an eye. The method of preventing a disease caused due to oxidative stress comprises.. More
Name of the principal inventor: Argiris Efstratiadis Research into the insulin- producing beta cell of the pancreas and the expression and secretion of insulin may offer avenues for the development of future treatments for diabetes mellitus, which... More
Lead Inventors: lrena Kirman, MD, Ph.D. and Richard L. Whelan, MD Technology to be Commercialized: This invention provides a method of preventing the proliferation of metastases and recurrence of cancer following open surgical resection of tumor mass.... More
Lead Inventors: lrena Kirman, MD, Ph.D. and Richard L. Whelan, MD Technology to be Commercialized: This invention provides a method of preventing the proliferation of metastases and recurrence of cancer following open surgical resection of tumor mass.... More
Name of the inventor: David Mark Stern An isolated nucleic acid encoding an endoplasmic reticulum associated amyloid-beta peptide binding (ERAB) polypeptide is described. The ERAB polypeptide may comprise human ERAB polypeptide. A purified ERAB... More
Name of the inventor: Seth Lederman MD Isolated protein fragments of p62 nucleoporin including deletion isoforms and nucleic acid sequences encoding these deletion isoforms and pharmaceutical compositions methods for their use activating target genes are. More
Name of the inventor: Shouri Chatterjee Circuits that operate with supply voltages near/lower than the threshold voltage of transistors and capable of operating with power supplies of less than 1 Volt is described. Operational transconductance amplifiers. More
Lead Inventors: Stephen L. Sturley, Ph.D. Problem or Unmet Need: Triglycerides are fatty acids with wide ranging functions in the body, from energy storage to cellular structure. Triglycerides play a key role in obesity, diabetes and arteriosclerosis;... More
The presented technology demonstrates a novel method by which laparoscopic surgical instruments can be anchored to points on the interior surface of the abdominal cavity, and stabilized using a unique magnetic circuit. More
This technology seeks to refine this practice by using force sensors and a feedback loop to control the strength of the magnetic attraction. More
Name of the Inventor: Seymour Lieberman A method for improved drug delivery which involves the production of lipophilic complexes of non-lipophilic pharmaceutically important agents has been developed. These stable complexes are produced by treatment of.. More
Name of the inventor: Joyce Lustbader Synthetic FSH which exhibit increased serum half –life when compared to FSH are described. FSH analogues can be expressed as single chain polypeptides having both the .alpha. and .beta. subunits of FSH and a... More
Name of the inventor: Joyce Lustbader Compositions containing vascular endothelial growth factor-follicle stimulating hormone (VEGF-FSH) compounds where VEGF-FSH compounds have increased serum half-lives relative to either native VEGF or FSH, are... More
Name of the primary inventor: Jeremy Mao Invention: Composition and methods to promote sustained dermatologic remodeling and rejuvenation. Unmet Need: Collagen, fat, autologous fibroblast, synthetic fillers, Botox injected into the skin or lips to create. More
Name of the principal inventor: Clark Hung Allografts of articular cartilage are used clinically in tissue-transplantation operations and experimentally as model systems to study behavior of chondrocytes in their native extracellular environment.... More
Lead Inventor: Ottavio Arancio, M.D., Ph.D. The Challenge/ Problem/ Unmet Need: Alzheimer's disease (AD) is the 7th leading cause of death, it was responsible for 65,829 deaths in the U.S. in 2004 and this number continues to rise. At over $100 B per... More
Lead Inventors: Alan Tall, Tae-Wan Kim, Yu Sum Problem or Unmet Need: Formation of amyloid beta-peptide (Ab) plaques in the brain is the hallmark of Alzheimer's disease. Reversing or even halting the brain's deterioration requires effective treatments... More
Name of the inventor: Rudolph L. Leibel MD The invention provides an isolated mahoganoid polypeptide, isolated mahoganoid nucleic acid, pharmaceutical compositions, related therapeutic methods and articles of manufacture A method for... More
Name of the inventor: Paul Fisher A method for treating cancer in a subject by generating an effective amount of melanoma differentiation associated gene-7 (MDA-7) and one or more free radicals within the cancer cells of the subject is disclosed. An... More
Name of the inventor: Andrew Marks Related Technologies: IR# 1007 & IR# 1911 A medical device coated with the HDAC inhibitors for use in inhibiting proliferation and/or migration of smooth muscle cells is described. The medical device has a coating... More
Lead Inventor: Lucian V. Del Priore, M.D., Ph.D. Problem or Unmet Need: The medical devices industry is one of the most vital, dynamic and fastest-growing sectors in the healthcare market; however its full potential is limited in part by lack of patient.. More
Lead Inventors: Ira Tabas, M.D., Ph.D. Problem or Unmet Need: Coronary artery disease (CAD) is the leading cause of death worldwide, being the most common cause of sudden death. The severity of CAD in a patient is directly related to the degree of... More
Name of the Inventor: Bashir Zikria Within the past decade there has been increasing evidence clinically and experimentally for the presence of generalized leaky capillaries in most ischemia- reperfusion injuries, shock syndromes, sepsis, cardiopulmonary. More
Name of the inventor(s): Justin Starren and Michael Charney A method for providing a web page with an audio interface for activating web pages by voice is disclosed. A system for interacting with a visual web page having an audio interface includes... More
Lead Inventor: Marcelo Bento Soares Problem or Unmet Need: cDNA libraries are the main resource utilized for identification of genes. Finding the gene of interest, however, is usually a rather hard task. This is so because the frequency of the different.. More
Name of the inventor: Dusan Bartsch Description: A method for enhancing long-term memory in a subject with repressed cAMP (cyclic adenosine monophosphate) responsive gene expression is described. An effective amount of a therapeutic agent that is capable. More
Lead Inventors: Wayne Hendrickson, Ph.D., Richard Axel, M.D., Filippo Mancia, Ph.D., Paul Lee, M.D., Ph.D. Problem or Unmet Need: G Protein Coupled Receptors (GPCR) represent the largest class of proteins targeted by therapeutics. Development of these... More
Name of the inventor: Richard Axel Eukaryotic cells are subjected to co-transformation procedures under suitable conditions to express desired proteinaceous substances. Eukaryotic cells are co-transformed with foreign DNA (DNA I) molecules encoding the... More
Name of the inventor: William Clark Still Method and compounds for re-sensitizing vancomycin resistant bacteria by cleaving the ester bond in the cell wall peptide precursors are described. The method involves contacting the bacteria with an activated... More
Name of the inventor: Oliver Hobert Methods for the isolation and characterization the exc-4 gene of C. elegans and for determining whether a specific member of the CLIC gene family is involved in tubulogenesis are described. A method of determining... More
Name of the Inventor: Andrey Rzhetsky A method for identifying the probability of unknown molecular interactions within biological networks based on the representations of molecules is described. The method involves the representation of molecules as... More
Name of the inventor: Ira Tabas Method for treating a subject suffering from conditions associated with an extracellular zinc sphingomyelinase is described. The method for determining whether a compound inhibits an activity of an extracellular zinc... More
Lead Inventor: Vincent P. Butler Jr., M.D. Problem or Unmet Need: Myelin is an insulating material coating many types of neurons which allows proper conductance of their electrical signals. Disturbance of this myelin sheath can result in a host of... More
Name of the Lead Inventor: Yan, Shi Du Problem or Unmet Need: Multiple Sclerosis (MS) is a relatively common neuro-immunological disorder predominantly affecting young females. It is a demylinating disease where the myelin sheath that helps neurons to... More
Name of the inventor: Syngcuk Kim A method for reducing sensory nerve activity in a hypersensitive tooth and for desensitizing hypersensitive dentin by applying an appropriate potassium salt on the exposed surface of the dentin is proposed. Potassium... More
Name of the inventor: Charles Lawson A method of selectively decreasing pulmonary vascular resistance is described. Pulmonary vascular resistance is selectively decreased by administering endotracheally or endobronchially, an effective amount of an agent. More
Name of the inventor: Taka-aki Sato Ph.D. Method of preparing a protein array based on biochemical protein-protein interaction is described. Array of a first protein comprising a PDZ domain is deposited on a substrate. A second protein is applied to the.. More
Lead Inventor: Charles Emala, M.D. The Challenge/ Problem/ Unmet Need: Millions of Americans suffer from asthma and chronic obstructive pulmonary disease (COPD) and bronchoconstrictive diseases have increased in frequency and associate mortality... More
Name of the inventor: Ira Lamster A method of testing for periodontal disease in a subject by detecting an elevated concentration of beta-glucuronidase in saliva from the subject relative to the concentration of beta-glucuronidase present in the saliva... More
Name of inventor: Judah Weinberger Restenosis is a significant limitation of coronary angioplasty (PCTA), a common treatment option for patients with coronary artery disease. There are currently more than 500,000 PTCA procedures performed in the U.S.... More
Name of the inventor: Stephen Sturley The method involves administration of a therapeutically effective amount of an agent to a subject which inhibits acyl-CoA wax alcohol acyltransferase 1 (AWAT1) and/or acyl-CoA wax alcohol acyltransferase 2 (AWAT2).... More
Name of the inventor: Steven P. Engebretson DDS, PhD Methods for facilitating metabolic control and for decreasing the level of circulating TNF in a subject are described. The use of anti-inflammatory agents in these methods is also discussed. The method. More
Lead Inventors: Maria Karayiorguo, PhD, Bin Xu, PhD, and Joseph Gogos, PhD Problem or Unmet Need: Though scientists can agree that there is a genetic component to the psychiatric disorder of schizophrenia, little is known of the genetic architecture.... More
Name of the inventor: Thomas Briese A real-time PCR assay used for detection of the SARS-associated coronavirus is described. A synthetic nucleic acid sequence may be the N gene region of the SARS-associated coronavirus genome or the 3' non-coding region. More
Name of the inventor: Hong Yu Methods for extracting gene and/or protein synonyms from text using one or more of expert knowledge or machine learning techniques, including unsupervised, partially supervised, and supervised machine learning techniques are. More
Name of the inventor: William Louis Cleveland A method and system to identify and localize objects belonging to a given class by generating a confidence map is described. The method identifies and localizes objects in a sample, where the objects include.. More
Lead Inventor: Anna Lasorella, MD Problem or Unmet Need: The mortality from pediatric cancers can be reduced if tumors are diagnosed and treated at an early stage. Moreover, current treatment protocols can be invasive (surgery) or can produce deleterious. More
Lead Inventors: Kevan Herold, Virginia Papaiouannou Problem or Unmet Need: There is no practical cure to date for type 1 diabetes. Since type 1 diabetes is due to failure of producing insulin, studies have led to cue by replacing the pancreas or only the. More
Name of the inventor: Taka-aki Sato A composition capable of inhibiting specific binding between a signal-transducing protein and a cytoplasmic protein is described. A method of identifying a compound capable of inhibiting specific binding between a... More
Lead Inventors: Ottavio Arancio, M.D., Ph.D., Michael Shelanski, M.D., Ph.D. Problem or Unmet Need: Alzheimer's disease (AD) is a neurodegenerative disorder, initially characterized by memory loss, progressing to dementia and death. Approximately 4.5... More
Name of the inventor: Martin Chalfie Description: Methods for isolating specific types of cells from Caenorhabditis elegans and identifying particular reference nucleic acids which hybridize with the isolated nucleic acid are described. A method for... More
Name of the inventor: Paul Fisher Compositions and methods for modulating angiogenesis and vaccines and pharmaceutical compositions comprising such compounds are described. The method for modulating angiogenesis in an organism comprises administering to.. More
Name of the inventor: Saul Silverstein A method for treating a subject either during or soon after a seizure, in order to reduce the extent of the resulting neuronal damage is described. A method for inhibiting neuronal damage comprises administering a... More
Name of the inventor: Lloyd Greene The direction of progenitor cells along specific pathways of neuronal differentiation is discussed. A method for promoting differentiation of a neural stem cell or a neural progenitor cell in vivo or in vitro into a... More
Name of the inventor: Taka-aki Sato A method for producing a polypeptide capable of binding p75.sup.NT receptor into a suitable vector is proposed. An antisense oligonucleotide has a nucleic acid sequence capable of specifically hybridizing to an mRNA... More
Lead Inventors: Thomas Diacovo, Jianchun Chen Problem or Unmet Need: One major hurdle hindering antithrombotic drug development is the lack of an appropriate small animal model of thrombosis to test promising therapies, as in vitro models of thrombosis... More
Name of the inventor: Joseph Isler Methods and systems for monitoring and evaluating brain electrical activity and for obtaining local synchrony between adjacent/neighboring brain regions or neural sites are described. A system for obtaining local... More
Lead Inventor: Dr. Nicole Suciu-Foca The Challenge/ Unmet Need: Immunological tolerance is the ability of an individual to differentiate 'self' from 'non-self'. Loss of this tolerance leads to the immune system mounting an immunogenic attack against... More
Name of the inventor: Martin David Tilson III Methods of treating or preventing a cardiovascular disease, a peripheral vascular disease, or an aneurysm in a subject. The inventors have identified a nutraceutical formulation which inhibits abdominal... More
Name of the inventor: David Carling Methods of assaying, monitoring and modulating LKB1 activity and its downstream targets are described. The use of AMPK (AMP activated protein Kinase) in the manufacture of medicaments for the treatment/prevention of... More
Name of the inventor: Laurence Berlowitz-Tarrant A method for eliciting an enzymatic repair response in a damaged catilage is described. Proteoglycanases or proteases are used to repair the damaged connective tissue. A therapeutically effective amount of. More
Name of the inventor: Alexander Krichevsky A method of lysing malignant cells using antibodies against human chorionic gonadotropin-related determinants. Malignant cells are brought into contact with an antibody specific for the beta subunit of human... More
Lead Inventors: Dr. Hong Jiang, Dr. Leonard Chess STV Reference: IR 1979, 1779, 500 Problem or Unmet Need: T cells play critical roles as effectors and regulators of cell-mediated immune responses. This is based upon the immune system's ability to... More
Lead Inventors: Dr. Hong Jiang, Dr. Leonard Chess STV Reference: IR 1979, 1779, 500 Problem or Unmet Need: T cells play critical roles as effectors and regulators of cell-mediated immune responses. This is based upon the immune system's ability to... More
Lead Inventors: Dr. Hong Jiang, Dr. Leonard Chess STV Reference: IR 1979, 1779, 500 Problem or Unmet Need: T cells play critical roles as effectors and regulators of cell-mediated immune responses. This is based upon the immune system's ability to... More
Lead Inventor: Ralph Buttyan Licensing Status: This technology is available for licensing Patent Status: United States Patent Publication 20070248535 A1 Further Information: Prostate. 2006 Jul 1; 66(10): 1100-13.... More
Name of the primary inventor: Jeremy Mao. Invention: A minimally invasive therapy for the treatment of craniosynostosis Unmet Need: Current therapy for craniosynostosis is limited to open-skull surgery, involving the reshaping, cutting and removal of... More
Name of the inventor: Vincent R. Racaniello An isolated nucleic acid molecule which encodes a polypeptide the biological activity of a picornavirus receptor. A purified polypeptide with the biological functions of picornavirus is also disclosed. A method. More
Name of the Inventor: Dorothy Warburton These hybrid cells are useful for many purposes in human genetic research including the mapping of genetic disorders and development of probes and mapping reagents from single chromosomes. The cells contain a... More
Lead Inventor: Howard Lieberman, Ph.D. See also: case number IR#585 Brief Description: Rad9 was previously identified by Dr. Lieberman (US Patent 5,882,862) and promotes cell survival through the regulation of DNA repair and the activation of cell cycle.. More
Lead Inventor: Howard Lieberman, Ph.D. See also: case number IR#1637 Brief Description: Rad9 was previously identified by Dr. Lieberman (US Patent 5,882,862) and promotes cell survival through the regulation of DNA repair and the activation of cell cycle. More
Lead Inventors: Denong Wang and T. Conrad Gilliam Problem or Unmet Need: A protein microarray is a coated glass slide onto which different proteins have been affixed in an ordered fashion. The most common protein microarray uses antibodies which are... More
Name of the inventor: Gustavo Palacios Ph.D. Systems and methods for determining the presence or absence of one or more target nucleic acid sequences in a sample and kits comprising these systems are described. The system comprises a capture nucleic acid. More
Lead Inventor: Valluvan Jeevanandam, M.D. Problem or Unmet Need: Despite advances and novel therapeutics, ischemic heart disease remains a major health problem in the developed world. Eligible patients can be treated by cardiac revascularization using... More
Lead Inventor: Michael Terman Problem or Unmet Need: It is estimated that about 10 million Americans suffer from winter depression at a fully syndromal level, with another 25 million suffering at a milder subsyndromal level which is less debilitating and. More
Name of the inventor: Marc Tessier-Lavigne Methods and compositions relating to netrins and netrin genes are described. Isolated polypeptides comprising a vertebrate/insect netrins or their portions which modulate axon outgrowth or guidance or elicits a.. More
Name of the inventor: Christine Kabbash A method for inhibiting bacterial growth by contacting the bacterium with a compound that inhibits enoyl reductase activity in a bacterial cell is described. The novel antimicrobial activity of gemfibrozil in terms. More
Name of principal inventor: Jeanine D'armiento Problem or Unmet Need: Chronic obstructive pulmonary disease (COPD) is a lung disease caused by cigarette use. It is the fourth leading cause of death in America; and has 11.4 million affected adults.... More
Lead Inventor: Dr. Gordana Vunjak-Novakovic Problem or Unmet Need: Cardiovascular diseases are responsible for a preponderance of health problems in many countries. Cell and stem cell therapy are promising new treatment strategies for many cardiovascular. More
Name of the inventor: C Dominique Toran-Allerand The method provides an isolated mammalian cell-surface estrogen receptor with specific characteristics and related methods for assaying compounds and treating disorders. A method for determining whether an. More
Lead Inventors: Tae-Wan Kim, Ph.D. Problem or Unmet Need: Alzheimer's Disease (AD) is a progressive neurodegenerative disease that affects 18 million people worldwide. There remains no cure for AD, and current therapies provide only temporary and... More
Name of the inventor: Denong Wang Ph.D. Novel nitrocellulose-based or hydrogel-based microarrays and methods of making and using them, including instant microarray kits are described. The kit detects the presence and amount of agents in a sample that... More
Name of the inventor: Martha Welch Description: Novel multipeptide regimens and associated kits comprising a combination of secretin and oxytocin for use in treating and/or preventing gastrointestinal disorders, central nervous system disorders,... More
Lead Inventor: Gregg G. Gundersen, Ph.D. Problem or Unmet Need: As the incidence of cancer continues to rise, additional therapeutic technologies are needed more than ever. Current adjuvant therapies inject hormones, antibodies, or other peptides into... More
Name of the inventor: Jeanine D' Armiento A method of treating or preventing a chronic obstructive pulmonary disease in a subject is described. A method for identifying a compound effective to treat or prevent a chronic obstructive pulmonary disease is... More
Name of the inventor: Rene Hen A method for determining whether an agent reduces anxiety and/or depression and a method to treat depression are described. The method for treating anxiety and depression in a subject afflicted with anxiety and/or... More
Lead Inventor: Larry Chasin Problem or Unmet Need: With the growing desire to safeguard spaces against bioterrorism and monitor agricultural and municipal areas for pesticide content and water quality, there is a need for a sensitive, robust, and cost... More
Name of the inventor: Paul Fisher A method for treating cancer in a subject by administering a nucleic acid comprising a rat PEG-3 promoter operatively linked to a gene-of-interest like a tumor suppressor gene or a cytotoxic gene is described. The gene... More
Name of the inventor: Paul Fisher Assay systems for use in identifying new anti-inflammatory agents, model systems of inflammation and methods and kits for diagnosing and treating OLD-35 associated inflammatory conditions. The method for identifying an... More
Name of the inventor: Rafael Yuste A method for identifying a connection/ inhibitory connection between a first neuron and a second neuron or plurality of neurons, for detecting the effect of a neuromodulator on this connection and to identify an... More
Lead Inventor: Randolph S. Marshall Problem or Unmet Need: Approximately 750,000 patients suffer a stroke in the United States annually. Of these, about two-thirds require rehabilitation for sequelae related to CNS damage, including aphasia, paralysis,... More
Name of the inventor: Francis Young-In Lee, M.D. Problem or Unmet Need: Orthopedic implants are widely used for joint and reconstruction surgeries that provide lasting pain relief and consistent functional improvement. The orthodontic and facial implants. More
Name of the inventor: Andrew Marks M.D. Related Technologies: IR# 1443 & IR# 1911 Methods of preventing cellular migration in treating cardiovascular diseases and tumor metastasis and methods of identifying chemical compounds for use in such treatments... More
Name of the inventor: Janet Sparrow A method of using single high-purity partially fluorinated ether liquids as a long-term tamponade agent is described. Tamponade agents are used to rectify the deficiencies of silicone and perfluorocarbon liquids. The... More
Lead Inventor: Desmond Jordan, M.D. Problem or Unmet Need: Due to time constraints, the structure, organization, and amount of information, and the relative importance of information to the briefing physician, there is little consistency in clinical... More
Lead Inventor: Karima Djabali, Ph.D. Problem or Unmet Need: Hutchinson Gilford Progeria Syndrome (HGPS), commonly referred to as Progeria, is a fatal condition caused by a genetic mutation in the human lamin A protein. This condition leads to accelerated. More
Lead Inventors: Cy Stein, Luba Benimetskaya, Nancy Guzzo-Pernell Problem or Unmet Need: Cancer is the second leading cause of death in the United States. When cancer has metastasized, it can only be cured by systemic therapy, usually cytotoxic... More
Lead Inventor: Michael Shelanski, M.D., Ph.D., Ottavio Arancio, M.D., Ph.D., Ottavio Vitolo, Ph.D. Problem or Unmet Need: Neurodegeneration leading to cognitive impairment and ultimately dementia represent a significant clinical challenge. Although... More
Name of the inventor: Cy Stein Antisense phosphorothioate oligonucleotides that specifically inhibit the translation of heparanase enzyme are described. Pharmaceutical compositions comprising antisense phosphorothioate oligonucleotides as active... More
Lead Inventor: Jingyue Ju, Ph.D. Problem or Unmet Need: Since the sequencing of the human genome was completed, the ability to sequence specific pieces of DNA has become increasingly important. Sequencing can be used for such purposes as detecting... More
Name of the inventor: Rafael Yuste Description: Novel photolabile compounds and methods for uncaging an organic molecule, such as a bioactive molecule are described. The photolabile compound is biologically active with the ligand and gets released when... More
Lead Inventor: Ian Lipkin Problem or Unmet Need: Respiratory tract infections may result in a wide spectrum of disease that ranges from minor discomfort to exacerbations of asthma and COPD/emphysema to acute fatal respiratory failure. During an... More
Lead Inventors: Xian-Cheng Jiang, Ph.D. and Alan R. Tall, Ph.D. Problem or Unmet Need: Cardiovascular disease has been the leading causes of illness in the U.S. for many decades. Atherosclerosis alone affects over 4.5 million people. Characterized by... More
Lead Inventor: Bashir Zikria STV Reference: IRs 473 / 476 Problem or Unmet Need: In sick patients inflammatory signals result in "capillary leak" allowing albumin to leak out of the capillaries into the interstitial space. Historically plasma volume has.. More
Name of the inventor: Helen Lu Methods and apparatus for osteochondral repair using a polymer-ceramic-hydrogel composite scaffold apparatus that functions as an interface between cartilage and bone are discussed. The apparatus and method for... More
Name of the inventor: Jeremy Luban An isolated nucleic acid encoding a TRIM-cyclophilin A fusion sequence which is active as an anti-viral agent, in particular against HIV-1 is described. The method for treating/preventing viral infection or reducing... More
Lead Inventor: Adam J. Ratner STV Reference: IR 2051, IR 2345 Problem or Unmet Needs: Bacterial vaginosis is an infection of the female genital tract by Gardnerella vaginalis bacteria, often in combination with other bacterial species. It is the most... More
Lead Inventor: Adam J. Ratner STV Reference: IR 2051, IR 2345 Problem or Unmet Needs: Bacterial vaginosis is an infection of the female genital tract by Gardnerella vaginalis bacteria, often in combination with other bacterial species. It is the most... More
Name of the inventor: William Blaner Methods of detecting compounds that are capable of inhibiting the enzymatic activity of human 9-cis retinol dehydrogenase in in-vitro and in-vivo conditions are described. The compounds capable of inhibiting human... More
Lead Inventors: lrena Kirman, MD, Ph.D. and Richard L. Whelan, MD Technology to be Commercialized: The invention provides a body fluid-based approach to diagnose, in a population of patients with inflammatory bowel disease (IBD), an individual's risk of.. More
Name of the Inventor: Keith Reemtsma A method has been developed for transplantation whereby donor tissue, organ, or blood is UV irradiated in vitro and subsequently transplanted into recipients. The investigators have demonstrated that this methodology.. More
Name of the inventor: Wayne Hendrickson A process for pan-genomic determination of three-dimensional macromolecular atomic structures using a unique combination of components is described. cDNAs from representative species included in a genomic database.. More
Name of the inventor: Joseph Lidestri Problem or Unmet Need: Short-lived radioisotopes such as Fluorine-18 (18F) are used in various biomedical applications such as Positron Emission Tomography (PET). These radioactive isotopes are typically produced... More
Name of the inventor: Paul Fisher An inducible PEG-3 regulatory region (promoter) and a gene encoding a toxic product that is capable of causing or may be induced to cause apoptosis/inhibition of cancer cell growth are described. A tumor suppressor gene.. More
Name of the inventor: Paul Fisher Cloning and characterization of the complete rat and human PSGen 13 cDNAs, the associated nucleic acids and encoded amino acid sequences and the suppressive effects of increased levels of PSGen 13 on the malignant... More
Name of the inventor: Paul Fisher A method for identifying a gene which is expressed at a modulated level in cancer and a method for identifying a compound which inhibits tumor growth are described. The method involves measuring a baseline mRNA... More
Name of the inventor: Mercy Davidson Description: This invention comprises of an immortalized human ventricular cardiomyocyte cell line established from non-proliferating primary cardiomyocyte culture. The cell lines express contractile proteins such as:. More
Name of the inventor: Jeanette Chloe Bulinski A vector carrying an isolated nucleic acid of interest linked to one or more nucleic acid segments encoding at least two green fluorescent proteins (GFP) is described. A method of detecting a nucleic acid... More
Name of the inventors: Richard L. Whelan, MD and Irena Kirman, MD, PhD Problem or Unmet Need Colorectal adenocarcinoma is the third most common cancer in the US with 150,000 cases diagnosed each year. It is a particularly dangerous cancer that kills... More
Lead Inventor: Michael R. Rosen, Richard B. Robinson, Peter R. Brink, Ira S. Cohen, Glenn Gaudette, Amy B. Rosen Problem or Unmet Need: Human mesenchymal stem cells (hMSCs) represent an attractive cell source for tissue repair and regeneration therapies.. More
Name of the inventor: Benjamin A. Bowen Description: Nucleic acid sequences encoding two RAD51 recombinases active in maize plants are provided. The production of plasmids containing a nucleic acid sequence encoding a ZmRAD51 fusion protein and their use. More
Lead Inventor: Howard B. Lieberman, Ph.D. Problem or Unmet Need: Prostate cancer is the second most prevalent cancer type in American men and is now the second leading cause of cancer death within this group. Currently, there are a number of treatment... More
Name of the inventor: Joseph John Mann Methods of making radiolabeled arylsulfonyl compounds, and its use as imaging agents for COX-2 enzyme are described. COX-2 protein expression in a subject is detected by administering an imaging-effective amount of.. More
Name of the inventor: Maureen M. Ward A retroviral packaging cell comprising a suitable mammalian cell comprising among others of a RD114 envelope gene and a selectable marker is described. Related production methods, virions and kits are also disclosed.. More
Name of the inventor: James L. Leighton Description: Reagents and their method of use in reactions with electrophilic compounds are disclosed. The method involves preparation of chiral alcohols and hydrazines by asymmetric allylation, aldol, tandem aldol. More
Name of the inventor: Paul Fisher A method for identifying differentially expressed nucleic acids between two samples is described. Reciprocal subtraction is performed between libraries of first and second nucleic acid samples. The two PCR amplified... More
Name of the inventor: Lloyd Greene PhD Methods for regulating the growth and/or survival of tumor cells and stem cells and kits for use in detecting and treating tumors are described. The method for regulating differentiation of a stem cell or a... More
Name of the primary inventor: Jeremy Mao. Invention: Method of inducing fibroblast differentiation from human mesenchymal stem cells (adult stem cells) Unmet Need: Currently, there exists no reliable and convenient way to differentiate stem cells or... More
Name of the Lead Inventor: Gloria Huei-Ting Su Problem or Unmet Need: Altered regulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway has been associated with cancer development. Somatic mutation of one PI3K signaling component, PIK3CA... More
Name of the inventor: Koji Nakanishi Description: Process for separating a terpene trilactone from Ginkgo biloba plant. The Ginkgo biloba extract is subjected to column chromatography with an appropriate solvent system and treated with a suitable eluent.. More
This technology consists of methods and devices for precise skin marking and suture holding. More
Name of the inventor: Rodney J. Rothstein An isolated Sml1protein or a homologue is described. A screening assay for identifying compounds that are capable of reducing the division rate of a cell by altering an interaction between a ribonucleotide... More
Name of the primary inventor: Jeremy Mao. Invention: Composition and methods for de novo and in vivo synthesis of adipose tissue implants in predefined and sustained shape and dimension. Unmet Need: Consumers and medical professionals continue to seek... More
Name of the primary inventor: Jeremy Mao. Invention: Composition and methods for de novo and in vivo synthesis of adipose tissue implants in predefined and sustained shape and dimension. Unmet Need: Consumers and medical professionals continue to seek... More
Composition and methods for de novo and in vivo synthesis of adipose tissue implants in predefined and sustained shape and dimension. More
Lead Inventor: Dr. David C. Paik Problem or Unmet Need: Keratoconus is a degenerative weakening of the cornea of the eye characterized by a cone-shaped bulge which impairs vision. The cause of keratoconus is unknown, and it affects 1 in 2000 people. Up... More
Name of the inventor: Christian W. Schindler A Stat5-specific protease polypeptide is described. The Stat5-specific protease is a partially-purified protease or a recombinant protease. A method for the identification of compounds or small molecules which. More
Name of the inventor: Liang Tong Description: A process for the preparation of ß-lactam antibiotics, cephalexin and ampicillin, where the ß-lactam nucleus is acylated with an acylating agent, D-phenylglycine. The method of synthesis comprises an... More
Name of the inventor: Gerhard Randers-Pehrson Method and apparatus for non-invasively determining the internal composition of objects is described. The phenomenon of neutron scattering is used to identify the existence of particular elements in closed... More
Name of the inventor: Norman Latov M.D. Method of detection and measurement of anti-glycolipid antibody levels in a sera solution using Surface plasmon resonance (SPR) biosensor is described. The method involves the measurement of the change in the SPR... More
Name of principal inventor: Raphael Clynes Autoimmune diabetes mellitus (type 1) is characterized by loss of the ability to produce insulin resulting from damage to the beta cells in the pancreas. In contrast, diabetes type 2 is caused by insulin... More
Name of the inventor: Samuel Danishefsky A method for the synthesis of an allyl pentasaccharide, related oligosaccharide ceramides and other glycoconjugates useful as vaccines in an adjuvant therapy. A method of inducing antibodies in a subject, wherein.. More
Name of the inventor: Edward J. Ciaccio A system and method for identifying and localizing a reentrant circuit isthmus and shape for catheter ablation during sinus rhythm is described. The method for identifying and localizing a reentrant circuit isthmus. More
Name of the inventor: Yves A. Lussier Method for creating an amalgamated bioinformatics database from another database is described. A method for integrating two databases without a common key is described. The method involves two databases which... More
Name of the inventor: Michael Sheetz Description: A cytoskeletal system composed of purified components which allows for the identification of key proteins involved in mechanotransduction is described. The method of identifying proteins involved in... More
Name of the inventor: Thomas M. Jessell Ph.D. In-vitro systems for use in identifying modulators of neural differentiation and modulators identified by these systems are described. The method for identifying a modulator of neural differentiation... More
Lead Inventor: Dattananda S. Chelur, Martin Chalfie, Ph.D. Problem or Unmet Need: While proper cellular apoptosis (cell death) is absolutely critical in the prevention of many forms of cancer, control and manipulation of this ubiquitous apoptotic pathway. More
Name of the inventor: Michael Rosen M.D. A method for treating a subject afflicted with a cardiac disorder and for determining whether an agent stimulates/inhibits myocyte proliferation is described. The method for treating a subject afflicted with a... More
Lead Inventors: Ton-That Ai Long, Gavreel Kalantarov and Ilya Trakht Problem or Unmet Need: Tissue microarrays are an emerging technology for the rapid molecular characterization of biopsy and cell culture samples. Arrays are formed by arranging many... More
Name of principal inventor: Samuel J. Danishefsky Problem or Unmet Need. Neurotrophic factors are responsible for the growth, maintenance and survival of neurons. They may be key in treating neurodegenerative diseases such as Alzheimer’s and... More
Name of the inventor: Paul Fisher Compositions and methods for cancer diagnosis, monitoring and therapy are disclosed. The pharmaceutical composition comprises a polypeptide and a physiologically acceptable carrier. The isolated polypeptide comprises a... More
Lead Inventor: Timothy C Wang Problem or Unmet Need: Gastric cancer is one of most common cancers in the world. Currently there is a major gap in preclinical testing of cancer drugs/chemotherapy, as most cancer models have not been physiologic and have... More
Name of the inventor: Isabelle Mansuy A transgenic non-human mammal whose germ or somatic cells contain a nucleic acid molecule encoding calcineurin or a variant thereof under the control of a promoter is described. The gene encoding calcineurin is... More
Name of the inventor: Isabelle Mansuy Methods for determining whether an agent inhibits long-term potentiation and/or learning and memory in a mammal are described. The method provides a transgenic nonhuman mammal and mammalian cell models. A method for.. More
Name of the inventor: Shi Du Yan MD Transgenic non-human animal models whose cells over-express (amyloid-beta alcohol dehydrogenase) ABAD and mutant APP in brain linked to familial Alzheimer's disease in humans are described. The method involves... More
Name of the inventor: David Mark Stern M.D. Transgenic non-human animal whose cells over-express (amyloid-beta alcohol dehydrogenase) (ABAD) in brain ABAD in brain linked to familial Alzheimer's disease in humans are described. The method involves... More
Lead Inventors: Antonio Iavarone and Anna Lasorella, MD Problem or Unmet Need: Current methods of treating tumors often involve chemotherapy, radiation therapy, or surgery. Unfortunately, all three have serious side effects associated with them.... More
Lead Inventors: Ilyas Washington, Ph.D. Problem or Unmet Need: Age-Related Macular Degeneration (AMD) is the most common cause of vision loss in the developed world for those over the age of 50, effecting over 20 million people in both the U.S. and... More
Lead Inventors: Stephen L. Sturley, Ph.D. and Stephen Trokel, M.D. The Challenge: Chronic dry eye syndrome (CDES) is one of the most common ocular problems. Although a number of etiologies result in CDES, the condition arises from a disruption of the... More
Lead Inventor: Michael Rosen, M.D. Problem or Unmet Need: In a normally functioning heart, the regular pumping of the atria and ventricles is directed by the heart's electrical system composed of components such as the sinus node and the atrioventricular. More
Lead Inventor: Howard J. Worman Problem or Unmet Need: Emery-Dreifuss Muscular Dystrophy (EDMD) is a form of genetic, degenerative muscular dystrophy disease affecting muscles used for movement (skeletal muscles) and heart (cardiac) muscle. The major... More
Name of the inventor: Shanta M. Modak Medical devices comprising synergistic combinations of triclosan and silver containing compounds and their preparation are described. The medical device is prepared by exposing a polymeric medical article with a... More
Name of the CU inventor: Seth Lederman. An effective method of treating conditions characterized by an aberrant or unwanted level of CD40-mediated intracellular signaling is elucidated. Over expression of a CRAF1 (CD40 receptor-associated factor 1) gene.. More
Name of the inventor: Domenico Accili Problem or Unmet Need: Type II diabetes is a very complex disease involving many tissues and several key protein components, two of which are insulin receptor and the transcription factor FoxO1. Recently, FoxO1 was... More
Name of the inventor: Xiao-Yan Qu An isolated nucleic acid molecule which is DNA, cDNA, genomic DNA, synthetic DNA or RNA that encodes the wild-type and mutant forms of a tumor suppressor gene is disclosed. A pharmaceutical composition which comprises an. More
Lead Inventors: Steven J. Feinmark and Richard B. Robinson Problem or Unmet Need: Most cancer cell markers have cross-reactivity to non-cancerous cell lines of the same tissue type. This can be deleterious to the identification of cancer cells for... More
Name of the inventor: Rodney J. Rothstein Ph.D A high-efficiency method to transfer extrachromosomal genetic material such as plasmid DNA into any Saccharomyces strain for use with the current gene disruption libraries is described. The yeast cell... More
Name of the inventor: Robert Winchester A method for treating rheumatoid arthritis or other forms of inflammatory arthritis is described. A pharmaceutical composition consisting of an effective amount of an agent selected and identified to inhibit the... More
Name of the inventor: Jerome Cantor A major cause of respiratory diseases, like chronic bronchitis and emphysema, is the loss elasticity in the lung. This characteristic of lung tissue is mediated in part by proteins called elastins; the lack of them... More
Name of the inventor: Richard J. Deckelbaum Preferential delivery of a pharmaceutical agent to a predefined tissue in a subject is described. The subject is administered an effective amount of an emulsified composition made of a therapeutic agent,... More
Name of the inventor: Jeanine D'armiento The use of metalloproteinase inhibitors in the treatment and prevention of pulmonary emphysema is described. The method involves admixing Metalloproteinase inhibitor in effective amounts with a pharmaceutically... More
Name of the inventor: Andrew Marks A stent coated with Y-27632 for implantation in a blood vessel is described. A method of treating restenosis in a subject by implanting a stent coated with Y-27632 is disclosed. Restenosis may be a result of coronary... More
Name of the inventor: Martin Chalfie A cell comprising a DNA molecule having a regulatory element from a gene, other than a gene encoding a green fluorescent protein and living organisms which comprise it are described. Various uses of a green... More
Lead Inventors: Denong Wang, Ph.D., Bernard F. Erlanger, Ph.D., Elvin A. Kabat, Ph.D. Problem or Unmet Need: Preventative medicine is widely accepted as a critical aspect of not only improving human health but also alleviating many pressures... More
Lead Inventors: Stephen L. Sturley, Ph.D.; Stephen Trokel, M.D.; Aaron Turkish, M.D. Problem or Unmet Need: Many of the products produced for cosmetic and pharmaceutical dermal applications contain lipids derived from plant and animal sources. These are.. More
Lead Inventor: Raphael Clynes Problem or Unmet Need: Many antibody vaccines fail to induce active immunity despite binding the proper target and activating an immune response. Development of anti-tumor and anti-pathogen antibody vaccines is inhibited by.. More
Name of the primary inventor: Jeremy Mao. Invention: Designs and methods for inducing de novo vascular formation and regeneration. Unmet Need: To-date tissue engineering successes have been limited to relatively thin or avascular structures (for example,. More
Name of the primary inventor: Jeremy Mao. Invention: Designs and methods for inducing de novo vascular formation and regeneration. Unmet Need: To-date tissue engineering successes have been limited to relatively thin or avascular structures (for example,. More
Name of the inventor: Saul Silverstein Methods for delivering an agent into a eukaryotic cell and for causing a eukaryotic cell to secrete a desired protein are described. A method for treating a subject afflicted with a disorder involves administering... More

Press Releases

(12th May 2009) Columbia University Science & Technology Ventures and EndoRobotics, Inc. have entered into an exclusive license agreement to develop and commercialize a micro-robotic imaging and surgical device platform designed to reduce the complexity of minimally inva More
(27th Apr 2009) Tocris Bioscience (www.tocris.com) today announced that they have entered into a license agreement with Columbia University Science & Technology Ventures (STV) for RuBi-GABA, a novel caged-GABA compound with significant applications for basic science rese More
(13th Apr 2009) Columbia University Science and Technology Ventures announced that it has signed a worldwide exclusive license agreement with PCAsso Diagnostics, LLC to develop and market a novel imaging technology for diagnosis of vascular leakage disorders of the retin More
(5th Apr 2009) Columbia University Science & Technology Ventures has announced that it has signed an exclusive license agreement with Vital View Limited to bring to market a medical device technology that aims to improve the success of in vitro fertilization (IVF) proce More
(19th Feb 2009) Columbia University Science & Technology Ventures (STV) announced today that Intelligent Bio-Systems, Inc. (IBS), exclusive licensee of certain Columbia DNA sequencing patents, has closed a round of financing led by Norwich Ventures of Waltham, Massachuse More
(11th Feb 2009) Columbia University’s Science & Technology Ventures announced that it has signed a license agreement with Stockbridge Pharmaceuticals, Inc. to commercialize a novel small molecule-based approach, developed in collaboration with the University of Nebraska, More
(22nd Dec 2008) Columbia University’s Science & Technology Ventures (STV) announced that it has licensed MedLEE, a robust and proven natural language processing technology, to Columbia spin-out, NLP International Corporation. More
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Formed: 1982
Number of employees: 49

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