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Pharmalicensing Ltd
is a division of
UTEK Corporation
Companies

National Institutes of Health (NIH)

NIH achieves its mission of improving human health through a combination of biomedical research, training, and communication.

The company in detail

Profile

The NIH Office of Technology Transfer (OTT) evaluates, protects, monitors, and manages the NIH and FDA intramural research invention portfolios. These portfolios cover the broad spectrum of public health concerns including heart disease, cancer, infectious diseases, neurological disorders, respiratory illnesses, mental well-being, musculoskeletal disorders, drug/alcohol addiction, aging, and many others. Technologies include those with potential application as diagnostics, therapeutics, and vaccines; research materials are also available. Partnering Goals: To help achieve the NIH research goal of protecting and improving human health, we seek licensees and/or Cooperative Research and Development Agreement (CRADA) partners to further develop and commercialize the novel research discoveries that are made here.

Partnering strategy/interests

Licensing Technology at NIH NIH has an extensive intellectual property portfolio of early- stage technologies and also invests substantially in their development. Roughly 10 percent of the annual NIH budget is dedicated to intramural research and development activities -- resulting in inventions that form the basis of a variety of new medical technologies and therapies in the areas of medical devices, software, vaccines, diagnostics, and reagents. Similar to university research, commercial partners are needed to ensure that long hours at the lab bench and the public's investment pay off in the end in marketed products. The NIH technology licensing program is the most successful technology transfer program in the federal government in terms of commercialized products. Over the last 15 years, there have been 23 FDA-approved products developed with technologies from the NIH Intramural Research Program. During the 5-year period of fiscal years 2001 to 2005, NIH executed 1,229 licenses and sales of commercialized products during the same period generated $305 million in royalties. Overall product sales from NIH licensees exceed $5 billion on an annual basis. In the most recent Department of Commerce survey (FY2003), NIH royalties accounted for 56 percent of all federal royalties. Cooperative Research and Development Agreements (CRADAs) at NIH CRADAs provide an exciting opportunity for NIH investigators to join with their colleagues from industry and academia in the joint pursuit of common research goals. NIH scientists can leverage their own research resources, as well as serve the larger mission of NIH, to facilitate the development and commercialization of health-care pharmaceuticals and products. Companies also can leverage their own R&D efforts while collaborating in state-of-the-art NIH research. The purpose of a CRADA is to make government facilities, intellectual property, and expertise available for collaborative interactions to further the development of scientific and technological knowledge into useful, marketable products. Each NIH institute has a Technology Development Coordinator who will assist the company and the NIH investigator in developing the proper documents and obtaining required approvals. Important inventions, such as TAXUS® Express2™, the hepatitis A vaccine, and Laser Capture Microdissection were commercialized in part under CRADAs with industry. In FY2005, NIH executed 80 new CRADAs.

Out-licensing

Compounds which cross the blood brain barrier and retain activity against CNS specific cancer cell lines More
Discovery of a promising new class of potent alkyltransferase inactivators, 2-amino-O4-benzylpteridine derivatives More
New immunotoxins comprising a mutant diphtheria toxin linked to an anti-prostate specific membrane antigen (PSMA) fold-back diabody More
Use of substituted or modified C60 fullerenes for the prevention or treatment of thrombosis, peripheral arterial occlusion, and catheter obstruction. More
Unique proangiogenic biomarkers isolated from ovarian endothelial cells More
This is a highly effective vaccine suitable for children and should find utility in endemic regions and as a traveler's vaccine. More
The present invention utilizes the characteristic chemical property of hydrazide groups on one reactant to react with aldehyde groups or cyanate esters on the other reactant with an improved conjugate yield of at least sixty percent. More
A microRNA gene expression profile in prostate cancers that correlates with androgen responsiveness More
Methods for recognizing a new pattern of EEG activity called neuronal avalanche size (NAS) that has been correlated with cognitive function and epilepsy. More
A new method for enhancing L-ASP activity by combining it with antagonists of asparagine synthetase - such as siRNAs, antisense nucleotides, antibodies or small-molecule inhibitors More
This technology involves the generation of several novel mouse monoclonal antibodies against a sub-domain of an MITF fragment that is cleaved during cell death. More
A vector DNA that expresses the luciferase gene under the influence of a hypoxia inducible promoter sequence from the nitric oxide synthase gene has been used to transform various human tumor cell lines More
This Gram-negative bacterium, named Granulibacter bethesdensis, can breakdown methanol, formaldehyde, ethanol and their intermediate breakdown products into non-toxic end-products. More
Methods and compositions for the improved treatment of metastatic tumors by using a CXCR4 antagonist in conjunction with conventional monoclonal antibody based immunotherapy or immunostimulatory chemotherapeutics. More
A novel RF coil circuitry scheme to remove inductive coupling and to overcome the limitations of having to use overlapping geometries and low-impedance preamplifiers. More
Novel magnetic resonance angiography (MRA) method that accomplishes uniform contrast enhancement between coronary arteries and the surrounding tissue across the entire imaging volume More
Methods for SrgT synthesis and suggested modifications for production of SrgT analogs and related peptides More
Findings indicate that activation of Nurr1 may be therapeutically useful for Parkinson's disease patients; therefore, the mice would be useful in Parkinson's disease research. More
New analogs of NSC 73306 with improved selectivity and solubility, and the use of the analogs as therapeutics More
The available material provides a model system in which to test new antiviral treatment efficacy as well as the development of multi-drug-resistance to HIV-1 reverse transcriptase inhibitors. More
Implementation of triplex systems that significantly enhance R434 in vitro activity is offered as an alternative to the antisense oligodeoxynucleotide treatment of cervical cancer More
Identification of three genetic markers in the ABCB1 gene that can be used to predict the degree of neutropenia and peripheral neuropathy that an individual will experience following paclitaxel treatment More
This invention relates to a novel MRI compatible and active visible catheter for conducting interventional and intraoperative procedures under the guidance of MRI. More
An alternative type of immunotherapy which involves the adoptive transfer of autologous natural killer (NK) cells More
A method of transfecting isolated autologous T-Lymphocytes with endogenous cytokines, for example IL-7 and IL-15, to sustain an adoptive T-lymphocyte response without systemic toxicity. More
The current invention improves ACT by including a pre-treatment regimen to ensure permissive conditions in the host for in vivo proliferation of the transferred cells. More
Peptides and antigen epitopes specific for RCC for use in the diagnosis, vaccination, or adoptive infusion of antigen specific T cells to treat patients with metastatic RCC More
Inactivation of this protein improves therapeutic effectiveness of chemotherapy drugs that modify O6-position of DNA guanine residues. More
Immunogenic and therapeutic compositions related to HIV p28TEV protein, the first protein expressed during HIV infection in the case of the pHXB2 isolate More
A plasmid construct consisting of survivin promoter driven mutant form of bax that is constitutively active More
Methods of using a cyanovirin-N (CV-N) peptide, protein, or nucleic acid in the prevention and/or treatment of infection More
Compositions and methods for detecting the presence of marinobufagenin in a biological sample More
Compositions, pharmaceutical compositions, and methods for stimulating/increasing cell differentiation, particularly related to the treatment of tumors which have increased Notch-1 expression More
Invention can be developed as an inhibitor therapeutically or prophylactically against retroviral and non-retroviral infections, and can be used in combination with other anti-viral agents to treat patients who have drug-resistant virus. More
Rabbit polyclonal antibodies that recognize the human and mouse S100A15 proteins More
Polyclonal rabbit antisera that specifically detect mouse PDK-1 protein phosphorylated at Ser244 More
A novel PARG-like enzyme, ARH3, that appears to function in two important signaling pathways, serving to regulate both poly-ADP-ribose and O-acetyl-ADP-ribose levels. More
A system to quantitate virus neutralization and entry, utilizing pseudotyped lentiviral vectors that mimic properties of the influenza virus. More
This new technology is designed to screen for the autoantibodies for a spectrum of secreted tumor antigens in a single assay. More
Avian influenza vaccine specifically designed for poultry and other avian species. More
These analogs may increase water solubility and bioavailability for improved therapeutic formulation and utility More
Two novel classes of compounds useful as radioligands for in vivo imaging of beta-amyloid peptides and plaques in humans More
Semiconductor nanocrystals with detectable luminescent properties useful for imaging of cancer or other disease tissues More
Identification of a novel class of potent vacuolar-type (H+)-ATPase-inhibitory compounds More
The invention relates to methods of quickly and accurately diagnosing renal cellular carcinoma (RCC) and monitoring renal tissue health as well as RCC treatment. More
A millifluidic bioreactor system for culturing, testing, and fabricating natural or engineered cells and tissues More
Nucleic acids encoding human Cartilage-Derived Morphogenetic Protein-1 (hCDMP-1) variant polypeptides More
Broad spectrum antiviral compounds for treatment of infection caused by enveloped viruses More
Novel anti-HIV human monoclonal antibody exhibits a unique binding activity compared to its counterparts. More
These compositions may represent potential anticancer therapeutics, stimulating NY ESO-1/CAG-3-specific T cells to elicit an anti-cancer immunogenic response and thereby eliminating or reducing the cancer. More
The invention embodies the CCR5 genetic sequence, cell lines and transgenic mice, the cells of which coexpress human CD4 and CCR5, and which may represent valuable tools for the study of HIV infection and for screening anti-HIV agents. More
The various properties of this PE cell line differ from keratinocytes, which will provide a growth advantage to the PE cell lines during tumor promotion. More
Tissue engineered intervertebral discs comprising a nanofibrous polymer hydrogel amalgam having cells dispersed therein More
A tissue-engineered cartilage derived from a cellular composite made from a biodegradable, biocompatible polymeric nanofibrous matrix More
This technology is the first to show that subcutaneous administrations of chitosan and an appropriate antigen, with no other component, can be used for enhancing immune responses. More
Biodegradable microbead or microparticle useful for the sustained localized delivery of biologically active proteins or other molecules of pharmaceutical interest More
Gene constructs that express immunogenic proteins based on viral genes that have been optimized for expression in mammalian cells More
Methods for identifying a subject at increased risk for developing AMD by determining the presence of protective genotypes at either the BF/C2 locus and at the CFH locus. More
Compositions and methods for improving the growth characteristics of cells engineered to produce biologically active products such as antibodies or glycosylated proteins. More
Compositions and methods for treating immune related disease More
A mouse line homozygous for floxed alleles of the Arnt gene More
The present invention describes cytotoxic compounds with an intracellular target that can selectively enter tumor cells through specific receptors on the cell surface. More
The development of an infectious cDNA clone is important because it enables the use of More
Growth of these baculovirus recombinants in insect cells results in the expression of virus-like particles (VLPs) that are antigenically indistinguishable from the native calicivirus particle. More
Inventors at the National Institutes of Health have recently characterized and cloned both the yeast and human recombinant versions of the enzyme deoxyhypusine hydroxylase (DOHH) that catalyzes the final step in the modification of eIF5A. More
Screening for differential expression of vascular risk-related molecules More
A functional method to prevent microbial contamination during lyophilization and a simple means to prevent contamination More
Rapid diagnostic assay to identify individuals with Fabry disease and an effective mechanism of evaluating enzyme replacement therapy More
This technology identifies a 10 kD residue of osteopontin as a potential prognostic marker and therapeutic target for metastatic hepatocellular carcinoma (HCC). More
This technology identifies twenty five (25) new alternatively spliced transcripts of the BORIS gene. More
identification of the link between expression of individual members of the SPANX-gene cluster and malignancies, including prostate cancer More
The present invention provides assays for the detection of human RFX4_v3 polymorphisms or deficiencies that may lead to the determination of an individual's risk of developing hydrocephalus. More
Methods and compositions for treating cancer, using novel compounds derived from diamidine More
Highly predictive, cost-effective diagnostic assay capable of detecting whether an individual has suffered from an intracerebral hemorrhagic stroke and the likelihood of neurological recovery More
The compounds of this invention can be developed as novel anti-viral agents that can be used in combinational therapy, especially since they might be less toxic than other anti-viral agents. More
Through in vitro and in vivo tumor suppression experiments, the inventors have demonstrated that DLC-1 acts as a new tumor suppressor gene for different types of human cancer. More
Single vector DNA vaccine against influenza More
This new device allows rapid and painless punching/sampling More
These compounds inhibit the deubiquitination of proteins by targeting the deubiquitination enzymes in the protein degradation pathway. More
Method of diagnosing/prognosing B-cell lymphoma or leukemia development/progresssion More
A tracheal tube ventilation apparatus which efficiently rids patients of expired gases and promotes healthier breathing. More
The present technology describes recombinant poxvirus vectors encoding at least three or more costimulatory molecules and TAAs. More
Enriched NK cell populations and method of treating malignancies or prevent recurrence of malignancies and treating any hyperproliferative disorders with these enriched compositions More
This enzyme should facilitate studies aimed at developing therapeutic drugs for norovirus disease. More
This cell line may be used for elucidation of the mechanisms of CF, testing candidate complementary genes for correction of the observed CF abnormalities, and for developing and testing therapeutic CF drugs. More
These englerins and their derivatives exhibit selective and potent renal cell inhibitory activity in vitro. More
These cell lines have been used to advance understanding of the molecular mechanisms of lymphomagenesis, and may be useful for the identification of molecular targets for agents that can be developed for the treatment of lymphomas and other tumors. More
Novel methods of cell culture for production of human parvovirus B19 (B19). These specific cell lines demonstrate limited infectability and commonly produce little or no virus following initial inoculation with B19. More
This application relates to gene targeting, illustrated by the use of triplex-forming oligonucleotides (TFOs) More
This invention discloses an extracellular matrix (ECM) modifier protein named Anakin, detection of the Anakin protein as a marker for metastatic disease and use of Anakin as potential therapeutic target. More
A possible treatment of laminopathies, cellular aging and aging-related conditions such as HGPS through the use of farnesyltransferase inhibitors (FTIs) and other related compounds More
These improvements to CW-EPR will allow changes of blood perfusion and oxygenation in tumors to be observed in nearly real-time, while improved resolution will permit angiogenesis in and around tumors to be carried out in a non-invasive manner. More
Allows tumors to be visualized in situ, with high sensitivity and without hazardous radioactive probes More
The subject cDNA clone of the virus encodes proteins of the MD145-12 strain that, when expressed in vitro, exhibit properties that would be expected from those produced by the original infectious virus. More
A "gene cassette" containing the aadA1 (aminoglycoside adenylyltransferase) gene that increases protein expression levels when incorporated into a bacterial or eukaryotic host genome. More
A method of providing a therapeutic effect in human patients by administering to the patient CD34+ cells obtained from umbilical cord blood. More
This invention provides the human gene for Niemann-Pick Type C disease and the nucleic acid sequences corresponding to the human gene for Niemann-Pick Type C disease. More
The signal peptide can be used for directing the secretion of CV-N polypeptide. More
Colorless molecule that will bind and enhance the differential surface charge on protein complexes: The molecule has been demonstrated to work as well as Coomassie blue but will not interfere in gel assays critical for most investigations. More
Device that provides nurses or other health care workers with protection against accidental needle sticks More
Bitter taste receptor with potential application for improvement/masking of taste in foods and drugs More
A chimeric gp41 molecule with nanomolar HIV fusion inhibitory activity More
Several hybridomas that produce monoclonal antibodies (mAbs) useful in HIV research applications More
This waveguide provides a significantly higher laser power delivery capability and higher damage threshold. More
Novel, non-invasive vaccine strategy to elicit both systemic and mucosal immunity in typically poorly inductive sites More
Detection of HSV-2 based on a transforming nucleic acid sequence and its protein product More
These libraries express complete sets of protein fragments encoded by several Human and Avian Influenza strains including H1N1, H3N2, H5N1 and H7N7 and can be used for in depth analyses of plasma samples. More
Two anti-CD22 antibodies of human origin have been generated; each has the ability to recognize CD22 on the surface of Raji cells. More
In our studies, the absence of toxicity to "normal" cells coupled to its effectiveness on a wide range of cancer cell types suggests that PrAg-L1/LF may represent a novel cancer therapeutic. More
An anti-mesothelin antibody of human origin has been generated; it has the ability to efficiently recognize mesothelin on the surface of cells, and induce ADCC in mesothelin-positive cells. More
Human p53 mutants and identification methods using screening assays in the yeast Saccharomyces cerevisiae to functionally categorize expressed p53 mutant proteins. More
Uses of a p53 specific microRNA (miRNA): It has been reported that the tumor suppressive mRNA miR-34a (a downstream target of p53) is downregulated in HPV-infected primary keratinocytes. More
New peptide sequences derived from TIMP-2; they retain their in vivo anti-angiogenic property acting via the same mechanism as TIMP-2 and some of them have significantly higher activity than TIMP-2 More
Discovery of novel coding sequence polymorphisms in the human TAS1R genes More
The technology describes the humanization of a murine anti-carcinoma antibody CC49 which has been shown to react with Tumor Associated Glycoprotein 72 (TAG-72), an antigen which is expressed on human breast, ovarian, colorectal, and other carcinomas. More
The present invention involves the construction of hybrid anti-cancer TCR that is half mouse and half human. More
A hydropneumatic fluid control system in which cell culture media is perfused through a bioreactor by gas pressure where the direction of the gas directs the direction of perfusion. More
Cloning and characterization of the first folliculin interacting protein FNIP-1 and purified antibodies that selectively bind to an epitope of FNIP-1 More
SELDI-TOF based serum marker protein profiling enables minimally invasive detection of colon cancer with 96.7 percent sensitivity and 100 percent specificity More
A method of identifying a ligand as a candidate for incorporation into a pharmaceutical composition that modulates antigen presenting cell activity More
Systems and methods for evaluating the status and characterization of organs, determining their suitability for transplants, as well as restoring the viability of organs intended for transplants More
Multiple immortalized, malignant, human, adult prostate epithelial cell lines useful as models in epithelial cell oncogenesis studies and in the diagnosis and treatment of prostate cancer More
This invention discloses peptides for use in immunotherapy of tumors. More
This discovery involves human T-cell responses to human tumors. More
Identification and characterization of novel PAGE4 cytotoxic T-cell lymphocyte (CTL) epitopes and enhanced agonist epitopes. More
New methods of diagnosing and monitoring the progression or response to therapy of subjects with autoimmune hepatitis More
Assay should predict susceptibility to schizophrenia even before clinical symptoms are apparent, if aberrant ErbB function during development is a cause of schizophrenia and that function is expressed in peripheral blood cells throughout life. More
An in vitro hepatitis C virus (HCV) replication system that is capable of producing viral particles in a culture medium More
The novel technique can be used to diagnose medical disorders that are associated with alterations in water diffusion, such as stroke and several neurodegenerative diseases and other disorders for which diffusion tensor MRI is currently used. More
A novel non-invasive method for using carbon-13 magnetization transfer effects to determine and evaluate in vivo aspartate transaminase (AST) activity and levels in an organ, as a biomarker of disease and certain neurological disorders. More
Optimization of the genes encoding interleukins 12 (IL-12) and 15 (IL-15), resulting in higher levels of protein expression. More
DNA influenza vaccine encoding the matrix 2 (M2) protein; mouse studies showed that the use of M2 from H1N1 strain protected against a lethal challenge with H5N1 strain More
One of the described technologies provides for development of potentially broadly protective influenza vaccines, while the other seeks to improve immune response to the vaccine through increased receptor affinity. More
Disruption of transmembrane domain interactions More
These novel pyrazolidinyl compounds can stabilize p53 and induce apoptosis in mammalian cells through selective inhibition of ubiquitin E1. More
Stilbenedisulfonic acid derivatives for treatment of HIV-1 and other retroviral infections. More
A retroviral vector system comprising a packaging vector and a transfer vector, and a method of using the vectors for gene therapy. More
Methods and compositions for modulating oxygen homeostasis for therapeutic application More
This thick transparent gel allows for optimal positioning on tissue for imaging in a living animal. More
These new series of compounds have synthetic advantage over similar macrocyclic compounds and retain good binding affinity towards Grb2 SH2 domain. More
New method of cell surface display of single chain antibodies for affinity maturation in a mammalian system More
This technology can be developed into an assay to screen for breast cancer patients who will be responsive to doxorubicin treatment. More
This method and associated apparatus is capable of producing images based on magnetization phase modulation using data from stimulated echoes and anti-echoes. More
A validated high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry method for measuring the absolute quantities of fifteen endogenous estrogens and their metabolites in human urine. More
New monoclonal antibodies against megakaryocyte potentiation factor More
These bifunctional chelators are useful for radiolabeling targeting moieties with SPECT and PET radioisotopes for molecular imaging for diagnosis and/or treatment of cancer. More
This invention proposes methods to predict an individual's genetic susceptibility to venous thrombosis. More
Methods for diagnosis and therapy of cancer and other pathologies associated with oxidative stress by administering a nitroxyl contrast agent and employing magnetic resonance imaging (MRI) More
Methods of producing a population of purified non-alloreactive antigen-specific T cells that recognize an antigen of interest More
This method of partial-field of view acquisition and reconstruction of PC-MRI results in an increased temporal resolution, while maintaining high spatial resolution. More
A method to promote stem cell survival and proliferation by manipulating the phosphorylation state, a key protein in these processes More
Use of IL-21 to induce differentiation of immature B cells into memory B cells and plasma cells More
Five compounds that inhibit ABDG2 were identified More
This invention describes improved methods for the large scale manufacture of stable disulfide-conjugated antibody therapeutics. More
Use of cDNA microarrays to facilitate the identification of pulmonary neuroendocrine tumors More
Treatment of cultured infected cells with antisense p21 oligonucleotides or p21 short interfering RNA (p21 siRNA) significantly reduced replication of HIV-1. More
Combines effective aspects of antigen-vaccines, including peptides and other forms of vaccination, with enhancing molecules, including co-stimulation of T cell immunity for efficient vaccine development More
Methods, systems and transgenic animals useful for screening, diagnosing and treating FUS1 related disorders More
A vaccine construct that expresses fusion protein comprising human monocyte chemotactic protein-3 fused with tumor antigens. More
Role of D-Lys3 GHRP-6 (a known GHS-R antagonist, peptide) as a blocker of two well-known chemokine receptors -- CCR5 and CXCR4 More
Diagnostic and therapeutic methods are provided in this invention involving the correlation of polymorphic variants in MTHFD1 and other genes with relative susceptibility for various pregnancy-related and other complications. More
A novel method for a-priori evaluation of the therapeutic relevance of gene products for various diseases, in order to make drug development more cost-efficient. More
Techniques for measuring cell proliferation or for measuring secretion of collagenolytic factors, incorporating a three-dimensional hair follicle culture system More
Methods for improving pancreatic endocrine function and delaying the onset of diabetes by enhancing beta cell function using ligands and/or regulators of Notch receptors More
This invention provides a novel means of treating or inhibiting HIV and other viral infections by administering a retinamide compound to a patient suffering from or susceptible to such a viral infection. More
Methods for rapid and specific fluorescent staining of biological tissue samples that substantially preserve biological molecules such as mRNA. More
Antiviral activity of the compound described by the current invention has been established against multi-protease inhibitor-resistant HIV-1 variants and demonstrated effective in patients with widespread resistance to current protease inhibitors. More
Ligands that bind to EPOR but do not activate the receptor can target specific tumor cells with minimal detrimental effect on normal cells. More
Methods of treating cancer and other tumors by coadministration of a radiosensitizing amount of Triapine and ionizing radiation More
A model for studying T cell development, immunological based gastrointestinal disorders More
Unique distinctions of this design over other CNT based methods: complete isolation of the CNTs from chemical reactions concomitant with probe immobilization and target capture, and the CNTs functioning only as charge sensors. More
This device allows for safe in situ exploration of myofascial pain biochemistry with minimal system perturbation. More
A new approach for vaccines against M. catarrhalis More
An improved method for producing human growth hormone (hGH) in vitro or in vivo. This invention can be applied to a non-invasive method of gene therapy to achieve sustained delivery of this therapeutic protein. More
A large variety of cell lines, each expressing a particular HLA molecule and the plasmids encoding them, including soluble HLAs. This technology has broad application for development of vaccines and immunotherapeutics. More
Isolation and characterization of a novel neutralizing chimpanzee monoclonal antibody to HBV More
Compositions and methods which employ a combination of monoclonal antibodies which bind to HGF and prevent it from binding to its receptor met in a manner that HGF/met signaling is neutralized More
This antibody can be used in diagnostic and research applications related to Lyme disease or other Borrelia-caused conditions. More
An imaging agent specific for colonic polyps that overexpress glycoprotein alpha-L-fucose containing mucins More
An endotracheal tube cleaning apparatus comprised of a flexible central tube with an inflatable balloon at its distal end; affixed to the inflatable balloon are one or more silicone rubber shaving rings More
Immortalized cell lines that constitutively express different fluorescent proteins, in vitro angiogenesis assays, and a software application have been developed. More
Specific and sensitive microarray and multiplex assay for the simultaneous detection and discrimination of HCV, HBV, and HIV-1, which include both RNA and DNA genomes. More
Methods of treating or preventing inflammation associated with an autoimmune disorder, particularly inflammatory bowel disease, via administration of muramyl peptide More
For research and drug development for treatment of respiratory syncytial virus More
This invention identifies Hsp90 mutant residues that affect the chronological lifespan of yeast. More
Methods of administering N-acetylmannosamine or its derivative to treat muscular atrophy More
Devices consisting of a rigid molecular rod with a flexible molecular tether attached at each end that can be used to detect a wide variety of clinical and biowarfare reagents and/or modify endogenous molecules More