Farhad Imani

The Johns Hopkins University School of Medicine, Division of Clinical Immunology, Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA

Introduction

Immunoglobulin E (IgE) is an important component of hereditary allergic disorders (atopy) such as asthma, allergic rhinitis, urticaria, angioedema and atopic dermatitis. In the past thirty years the prevalence of allergic disorders, especially asthma, has risen steadily in the world. Since these disorders constitute a significant world health and economic impact, intensive research efforts have been allocated for their prevention and cure. In addition to the traditional immunotherapy approach utilising small quantities of the antigen (allergen) to induce tolerance, several new approaches are emerging. Since a critical component of allergic reactions is IgE, this molecule has been a target for several therapeutic strategies.

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